PMID- 26989753
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160318
LR  - 20201001
IS  - 2328-8957 (Print)
IS  - 2328-8957 (Electronic)
IS  - 2328-8957 (Linking)
VI  - 3
IP  - 1
DP  - 2016 Jan
TI  - Strongyloides stercoralis, Eosinophilia, and Type 2 Diabetes Mellitus: The 
      Predictive Value of Eosinophilia in the Diagnosis of S stercoralis Infection in 
      an Endemic Community.
PG  - ofw029
LID - 10.1093/ofid/ofw029 [doi]
LID - ofw029
AB  - Background.  This study examines the predictive value of eosinophilia for 
      Strongyloides stercoralis infection, as measured by enzyme-linked immunosorbent 
      assay (ELISA) testing, in an endemic community. In remote communities, 
      eosinophilia is frequently used as a proxy test for the presence of helminth 
      infections. Past studies of eosinophilia and Strongyloides infection have been 
      conducted in specific groups such as immigrants and refugees, or in 
      subpopulations of nonendemic communities, rather than in endemic communities. 
      Methods.  We conducted a cross-sectional study of the relationship between 
      eosinophilia and Strongyloides ELISA serology, as part of a study into the 
      relationship between S stercoralis infection and type 2 diabetes mellitus (T2DM) 
      in an Indigenous community in northern Australia. Results.  Two hundred 
      thirty-nine adults had their eosinophil count and S stercoralis ELISA serology 
      measured in 2012 and 2013, along with other biometric and metabolic data. 
      Eosinophilia was found to have a relatively poor sensitivity (60.9%), specificity 
      (71.1%), positive predictive value (54.6%), and negative predictive value (76.1%) 
      for S stercoralis ELISA positivity in this group. However, there was a more 
      constant relationship between eosinophilia and S Stercoralis ELISA positivity in 
      patients with T2DM (negative predictive value 87.5%). Conclusion.  This study 
      suggests that the presence or absence of eosinophilia is not an adequate proxy 
      test for S stercoralis infection in a community where the infection is prevalent, 
      and that the association between eosinophilia and S stercoralis ELISA positivity 
      is more constant in patients with T2DM.
FAU - Hays, Russell
AU  - Hays R
AD  - Kimberley Aboriginal Medical Council, Western Australia; James Cook University, 
      Cairns Campus, Smithfield.
FAU - Thompson, Fintan
AU  - Thompson F
AD  - Centre for Chronic Disease Prevention, Australian Institute of Tropical Health 
      and Medicine, College of Public Health, Medical and Veterinary Sciences , James 
      Cook University , Cairns.
FAU - Esterman, Adrian
AU  - Esterman A
AD  - Centre for Research Excellence in Chronic Disease Prevention, The Cairns 
      Institute, James Cook University, Cairns Campus, Smithfield, Queensland, 
      Australia; Sansom Institute of Health Service Research and School of Nursing and 
      Midwifery, University of South Australia, City East Campus, Adelaide.
FAU - McDermott, Robyn
AU  - McDermott R
AD  - Centre for Chronic Disease Prevention, Australian Institute of Tropical Health 
      and Medicine, College of Public Health, Medical and Veterinary Sciences, James 
      Cook University, Cairns; School of Population Health, University of South 
      Australia, Adelaide.
LA  - eng
PT  - Journal Article
DEP - 20160211
PL  - United States
TA  - Open Forum Infect Dis
JT  - Open forum infectious diseases
JID - 101637045
PMC - PMC4794948
OTO - NOTNLM
OT  - Strongyloides stercoralis
OT  - eosinophilia
OT  - type 2 diabetes mellitus
EDAT- 2016/03/19 06:00
MHDA- 2016/03/19 06:01
PMCR- 2016/02/11
CRDT- 2016/03/19 06:00
PHST- 2015/11/26 00:00 [received]
PHST- 2016/02/05 00:00 [accepted]
PHST- 2016/03/19 06:00 [entrez]
PHST- 2016/03/19 06:00 [pubmed]
PHST- 2016/03/19 06:01 [medline]
PHST- 2016/02/11 00:00 [pmc-release]
AID - ofw029 [pii]
AID - 10.1093/ofid/ofw029 [doi]
PST - epublish
SO  - Open Forum Infect Dis. 2016 Feb 11;3(1):ofw029. doi: 10.1093/ofid/ofw029. 
      eCollection 2016 Jan.