PMID- 26991264
OWN - NLM
STAT- MEDLINE
DCOM- 20170522
LR  - 20211204
IS  - 1530-0447 (Electronic)
IS  - 0031-3998 (Linking)
VI  - 80
IP  - 1
DP  - 2016 Jul
TI  - Effects of neonatal dexamethasone administration on cardiac recovery ability 
      under ischemia-reperfusion in 24-wk-old rats.
PG  - 128-35
LID - 10.1038/pr.2016.54 [doi]
AB  - BACKGROUND: Evaluations of stress-induced cardiac functional alterations in 
      adults after neonatal glucocorticoid (GC) treatment have been limited. In the 
      present study, we evaluated adult cardiac functional recovery during postischemic 
      reperfusion and measured cardiac gene expression involved energy metabolism in 
      rats neonatally treated with dexamethasone (DEX). METHOD: Male Wistar rats were 
      injected DEX in first 3 d after birth and controls were received saline (SAL). At 
      24 wk of age, insulin tolerance tests were performed, plasma lipid levels were 
      measured, and left ventricular function and myocardial infarct size were 
      evaluated. Expressions of genes involved in cardiac energy metabolism were 
      measured by quantitative real-time polymerase chain reaction (PCR) and western 
      blot. RESULTS: In 24-wk-old rats, neonatal DEX administration caused 
      dyslipidemia, impaired cardiac recovery function and increased size of 
      infarction, decreased cardiac expression of glucose transporter 4(GLUT4), 
      peroxisome proliferative-activated receptor gamma coactivator 1alpha (PGC-1alpha) and 
      ratios of phospho-forkhead box O1/forkhead box O1 (p-FoxO1/FoxO1) and phospho 
      AMP-activated protein kinase/AMP-activated protein kinase (p-AMPK/AMPK) but 
      increased pyruvate dehydrogenase kinase isoenzyme 4 (PDK4) expression compared 
      with controls. CONCLUSION: Neonatal DEX administration impairs cardiac functional 
      recovery during reperfusion following ischemia in 24-wk-old rats. Reduced cardiac 
      glucose utilization may contribute to the long-term detrimental effects caused by 
      neonatal DEX treatment.
FAU - Jiang, Xinli
AU  - Jiang X
AD  - Department of Ophthalmology, the Third Hospital of Hebei Medical University, 
      Shijiazhuang, China.
FAU - Ma, Huijie
AU  - Ma H
AD  - Department of Physiology, Hebei Medical University, Shijiazhuang, China.
FAU - Li, Chunguang
AU  - Li C
AD  - Department of Endocrinology, the Third Hospital of Hebei Medical University, 
      Shijiazhuang, China.
FAU - Cao, Yue
AU  - Cao Y
AD  - Department of Endocrinology, the Third Hospital of Hebei Medical University, 
      Shijiazhuang, China.
FAU - Wang, Yan
AU  - Wang Y
AD  - Department of Endocrinology, the Third Hospital of Hebei Medical University, 
      Shijiazhuang, China.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - Department of Physiology, Hebei Medical University, Shijiazhuang, China.
FAU - Liu, Yan
AU  - Liu Y
AD  - Department of Endocrinology, the Third Hospital of Hebei Medical University, 
      Shijiazhuang, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160318
PL  - United States
TA  - Pediatr Res
JT  - Pediatric research
JID - 0100714
RN  - 0 (Glucocorticoids)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.11.3 (AMP-Activated Protein Kinase Kinases)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - AMP-Activated Protein Kinase Kinases
MH  - Animals
MH  - Dexamethasone/*therapeutic use
MH  - Energy Metabolism/drug effects
MH  - Glucocorticoids/pharmacology
MH  - Glucose/metabolism
MH  - Heart/*drug effects
MH  - Male
MH  - Mitochondria/metabolism
MH  - Myocardial Infarction/physiopathology
MH  - Myocardial Reperfusion
MH  - Myocardium/metabolism
MH  - Protein Kinases/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Reperfusion Injury/*drug therapy
MH  - Time Factors
EDAT- 2016/03/19 06:00
MHDA- 2017/05/23 06:00
CRDT- 2016/03/19 06:00
PHST- 2015/09/03 00:00 [received]
PHST- 2016/01/08 00:00 [accepted]
PHST- 2016/03/19 06:00 [entrez]
PHST- 2016/03/19 06:00 [pubmed]
PHST- 2017/05/23 06:00 [medline]
AID - pr201654 [pii]
AID - 10.1038/pr.2016.54 [doi]
PST - ppublish
SO  - Pediatr Res. 2016 Jul;80(1):128-35. doi: 10.1038/pr.2016.54. Epub 2016 Mar 18.