PMID- 26992687
OWN - NLM
STAT- MEDLINE
DCOM- 20170103
LR  - 20170104
IS  - 1532-3102 (Electronic)
IS  - 0143-4004 (Linking)
VI  - 39
DP  - 2016 Mar
TI  - Ly49 knockdown in mice results in aberrant uterine crypt formation and impaired 
      blastocyst implantation.
PG  - 147-50
LID - S0143-4004(16)30013-3 [pii]
LID - 10.1016/j.placenta.2016.01.013 [doi]
AB  - Genetic knockdown (KD) of the mouse Ly49 receptor family is reported to result in 
      infertility despite the presence of zona-enclosed blastocysts in the uterus. Ly49 
      receptors regulate leukocyte functions particularly Natural Killer (NK) cell 
      functions and are analogous to human killer immunoglobulin-like receptors (KIRs). 
      Histological analyses of gd3.5-4.5 B6.Ly49(KD) uteri identified hatched but 
      retarded blastocysts with pyknotic nuclei, aberrant endometrial crypt formation 
      and impaired uterine lumen closure accompanied by a lack of primary 
      decidualization These data support peri-implantation roles for leukocytes 
      expressing the Ly49 receptor repertoire and may give insight into KIR-based 
      regulation of human infertility.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Leon, Lucy
AU  - Leon L
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      ON, Canada.
FAU - Felker, Allison M
AU  - Felker AM
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      ON, Canada.
FAU - Kay, Vanessa R
AU  - Kay VR
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      ON, Canada.
FAU - Tu, Megan M
AU  - Tu MM
AD  - Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, 
      Ottawa, Ontario, Canada.
FAU - Makrigiannis, Andrew P
AU  - Makrigiannis AP
AD  - Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, 
      Ottawa, Ontario, Canada.
FAU - Croy, B Anne
AU  - Croy BA
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      ON, Canada. Electronic address: croya@queensu.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160126
PL  - Netherlands
TA  - Placenta
JT  - Placenta
JID - 8006349
RN  - 0 (NK Cell Lectin-Like Receptor Subfamily A)
SB  - IM
MH  - Animals
MH  - Chorionic Villi/*abnormalities
MH  - Embryo Implantation/*genetics
MH  - Female
MH  - Gene Knockdown Techniques
MH  - Mice
MH  - Mice, Knockout
MH  - NK Cell Lectin-Like Receptor Subfamily A/*genetics
MH  - Pregnancy
MH  - Uterus/*abnormalities
OTO - NOTNLM
OT  - Decidual leukocytes
OT  - Ly49 gene family
OT  - Mouse implantation
EDAT- 2016/03/20 06:00
MHDA- 2017/01/04 06:00
CRDT- 2016/03/20 06:00
PHST- 2015/10/19 00:00 [received]
PHST- 2016/01/05 00:00 [revised]
PHST- 2016/01/14 00:00 [accepted]
PHST- 2016/03/20 06:00 [entrez]
PHST- 2016/03/20 06:00 [pubmed]
PHST- 2017/01/04 06:00 [medline]
AID - S0143-4004(16)30013-3 [pii]
AID - 10.1016/j.placenta.2016.01.013 [doi]
PST - ppublish
SO  - Placenta. 2016 Mar;39:147-50. doi: 10.1016/j.placenta.2016.01.013. Epub 2016 Jan 
      26.