PMID- 26992837
OWN - NLM
STAT- MEDLINE
DCOM- 20170626
LR  - 20220331
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Print)
IS  - 0161-6420 (Linking)
VI  - 123
IP  - 6
DP  - 2016 Jun
TI  - Ultra-Widefield Steering-Based Spectral-Domain Optical Coherence Tomography 
      Imaging of the Retinal Periphery.
PG  - 1368-74
LID - S0161-6420(16)00151-2 [pii]
LID - 10.1016/j.ophtha.2016.01.045 [doi]
AB  - PURPOSE: To describe the spectral-domain optical coherence tomography (SD OCT) 
      features of peripheral retinal findings using an ultra-widefield (UWF) steering 
      technique to image the retinal periphery. DESIGN: Observational study. 
      PARTICIPANTS: A total of 68 patients (68 eyes) with 19 peripheral retinal 
      features. MAIN OUTCOME MEASURES: Spectral-domain OCT-based structural features. 
      METHODS: Nineteen peripheral retinal features, including vortex vein, congenital 
      hypertrophy of the retinal pigment epithelium, pars plana, ora serrata pearl, 
      typical cystoid degeneration (TCD), cystic retinal tuft, meridional fold, lattice 
      and cobblestone degeneration, retinal hole, retinal tear, rhegmatogenous retinal 
      detachment, typical degenerative senile retinoschisis, peripheral laser 
      coagulation scars, ora tooth, cryopexy scars (retinal tear and treated 
      retinoblastoma scar), bone spicules, white without pressure, and peripheral 
      drusen, were identified by peripheral clinical examination. Near-infrared 
      scanning laser ophthalmoscopy images and SD OCT of these entities were registered 
      to UWF color photographs. RESULTS: Spectral-domain OCT resolved structural 
      features of all peripheral findings. Dilated hyporeflective tubular structures 
      within the choroid were observed in the vortex vein. Loss of retinal lamination, 
      neural retinal attenuation, retinal pigment epithelium loss, or hypertrophy was 
      seen in several entities, including congenital hypertrophy of the retinal pigment 
      epithelium, ora serrata pearl, TCD, cystic retinal tuft, meridional fold, 
      lattice, and cobblestone degenerations. Hyporeflective intraretinal spaces, 
      indicating cystoid or schitic fluid, were seen in ora serrata pearl, ora tooth, 
      TCD, cystic retinal tuft, meridional fold, retinal hole, and typical degenerative 
      senile retinoschisis. The vitreoretinal interface, which often consisted of 
      lamellae-like structures of the condensed cortical vitreous near or adherent to 
      the neural retina, appeared clearly in most peripheral findings, confirming its 
      association with many low-risk and vision-threatening pathologies, such as 
      lattice degeneration, meridional folds, retinal breaks, and rhegmatogenous 
      retinal detachments. CONCLUSIONS: Ultra-widefield steering-based SD OCT imaging 
      of the retinal periphery is feasible with current commercially available devices 
      and provides detailed anatomic information of the peripheral retina, including 
      benign and pathologic entities, not previously imaged. This imaging technique may 
      deepen our structural understanding of these entities and their potentially 
      associated macular and systemic pathologies, and may influence decision-making in 
      clinical practice, particularly in areas with teleretinal capabilities but poor 
      access to retinal specialists.
CI  - Copyright (c) 2016 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Choudhry, Netan
AU  - Choudhry N
AD  - Herzig Eye Institute, Toronto, Ontario, Canada. Electronic address: 
      netan.choudhry@gmail.com.
FAU - Golding, John
AU  - Golding J
AD  - Herzig Eye Institute, Toronto, Ontario, Canada.
FAU - Manry, Matthew W
AU  - Manry MW
AD  - Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, Ann 
      Arbor, Michigan.
FAU - Rao, Rajesh C
AU  - Rao RC
AD  - Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, Ann 
      Arbor, Michigan; Department of Pathology, University of Michigan Medical School, 
      Ann Arbor, Michigan. Electronic address: rajeshr@umich.edu.
LA  - eng
GR  - K12 EY022299/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, N.I.H., Extramural
DEP - 20160316
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
SB  - IM
MH  - *Diagnostic Techniques, Ophthalmological
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Ophthalmoscopy
MH  - Retina/anatomy & histology/*diagnostic imaging
MH  - Retinal Diseases/*diagnostic imaging/pathology
MH  - Retinal Pigment Epithelium/pathology
MH  - Tomography, Optical Coherence/*methods
PMC - PMC4877257
MID - NIHMS770963
EDAT- 2016/03/20 06:00
MHDA- 2017/06/27 06:00
PMCR- 2017/06/01
CRDT- 2016/03/20 06:00
PHST- 2015/12/10 00:00 [received]
PHST- 2016/01/07 00:00 [revised]
PHST- 2016/01/27 00:00 [accepted]
PHST- 2016/03/20 06:00 [entrez]
PHST- 2016/03/20 06:00 [pubmed]
PHST- 2017/06/27 06:00 [medline]
PHST- 2017/06/01 00:00 [pmc-release]
AID - S0161-6420(16)00151-2 [pii]
AID - 10.1016/j.ophtha.2016.01.045 [doi]
PST - ppublish
SO  - Ophthalmology. 2016 Jun;123(6):1368-74. doi: 10.1016/j.ophtha.2016.01.045. Epub 
      2016 Mar 16.