PMID- 26992957
OWN - NLM
STAT- MEDLINE
DCOM- 20161227
LR  - 20181202
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 159
DP  - 2016 May 15
TI  - Exendin-4, a glucagon-like peptide 1 receptor agonist, protects against amyloid-beta 
      peptide-induced impairment of spatial learning and memory in rats.
PG  - 72-9
LID - S0031-9384(16)30100-7 [pii]
LID - 10.1016/j.physbeh.2016.03.016 [doi]
AB  - Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) share specific 
      molecular mechanisms, and agents with proven efficacy in one may be useful 
      against the other. The glucagon-like peptide-1 (GLP-1) receptor agonist exendin-4 
      has similar properties to GLP-1 and is currently in clinical use for T2DM 
      treatment. Thus, this study was designed to characterize the effects of exendin-4 
      on the impairment of learning and memory induced by amyloid protein (Abeta) and its 
      probable molecular underlying mechanisms. The results showed that (1) 
      intracerebroventricular (i.c.v.) injection of Abeta1-42 resulted in a significant 
      decline of spatial learning and memory of rats in water maze tests; (2) 
      pretreatment with exendin-4 effectively and dose-dependently protected against 
      the Abeta1-42-induced impairment of spatial learning and memory; (3) exendin-4 
      treatment significantly decreased the expression of Bax and cleaved caspase-3 and 
      increased the expression of Bcl2 in Abeta1-42-induced Alzheimer's rats. The vision 
      and swimming speed of the rats among all groups in the visible platform tests did 
      not show any difference. These findings indicate that systemic pretreatment with 
      exendin-4 can effectively prevent the behavioral impairment induced by neurotoxic 
      Abeta1-42, and the underlying protective mechanism of exendin-4 may be involved in 
      the Bcl2, Bax and caspase-3 pathways. Thus, the application of exendin-4 or the 
      activation of its signaling pathways may be a promising strategy to ameliorate 
      the degenerative processes observed in AD.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Jia, Xiao-Tao
AU  - Jia XT
AD  - Department of Neurology, The Affiliated Xi'an Central Hospital of Xi'an Jiaotong 
      University College of Medicine, Xi'an, Shaanxi 710003, PR China.
FAU - Ye-Tian
AU  - Ye-Tian
AD  - Department of Neurology, The Affiliated Xi'an Central Hospital of Xi'an Jiaotong 
      University College of Medicine, Xi'an, Shaanxi 710003, PR China.
FAU - Yuan-Li
AU  - Yuan-Li
AD  - Department of Physiology, Key Laboratory of Cellular Physiology, Ministry of 
      Education, Shanxi Medical University, Taiyuan 030001, PR China.
FAU - Zhang, Ge-Juan
AU  - Zhang GJ
AD  - Department of Neurology, The Affiliated Xi'an Central Hospital of Xi'an Jiaotong 
      University College of Medicine, Xi'an, Shaanxi 710003, PR China.
FAU - Liu, Zhi-Qin
AU  - Liu ZQ
AD  - Department of Neurology, The Affiliated Xi'an Central Hospital of Xi'an Jiaotong 
      University College of Medicine, Xi'an, Shaanxi 710003, PR China.
FAU - Di, Zheng-Li
AU  - Di ZL
AD  - Department of Neurology, The Affiliated Xi'an Central Hospital of Xi'an Jiaotong 
      University College of Medicine, Xi'an, Shaanxi 710003, PR China.
FAU - Ying, Xiao-Ping
AU  - Ying XP
AD  - Department of Pathology, Shaanxi University of Chinese Medicine, Xianyang, 
      Shaanxi 712046, PR China.
FAU - Fang, Yan
AU  - Fang Y
AD  - Department of Pathology, Shaanxi University of Chinese Medicine, Xianyang, 
      Shaanxi 712046, PR China.
FAU - Song, Er-Fei
AU  - Song EF
AD  - Department of Biology, York University, Toronto, ON M3J 1P3, Canada.
FAU - Qi, Jin-Shun
AU  - Qi JS
AD  - Department of Physiology, Key Laboratory of Cellular Physiology, Ministry of 
      Education, Shanxi Medical University, Taiyuan 030001, PR China. Electronic 
      address: jinshunqi2009@163.com.
FAU - Pan, Yan-Fang
AU  - Pan YF
AD  - Department of Pathology, Shaanxi University of Chinese Medicine, Xianyang, 
      Shaanxi 712046, PR China. Electronic address: panyanfang2000@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160316
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Peptides)
RN  - 0 (Venoms)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
RN  - 9P1872D4OL (Exenatide)
SB  - IM
MH  - Amyloid beta-Peptides/*adverse effects/antagonists & inhibitors
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Exenatide
MH  - Glucagon-Like Peptide 1/*agonists
MH  - Male
MH  - Maze Learning/*drug effects
MH  - Memory/*drug effects/physiology
MH  - Peptides/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spatial Learning/*drug effects/physiology
MH  - Venoms/*pharmacology
OTO - NOTNLM
OT  - Amyloid-beta peptide
OT  - Bcl2/Bax
OT  - Caspase-3
OT  - Exendin-4
OT  - Spatial learning and memory
EDAT- 2016/03/20 06:00
MHDA- 2016/12/28 06:00
CRDT- 2016/03/20 06:00
PHST- 2015/10/23 00:00 [received]
PHST- 2016/03/10 00:00 [revised]
PHST- 2016/03/14 00:00 [accepted]
PHST- 2016/03/20 06:00 [entrez]
PHST- 2016/03/20 06:00 [pubmed]
PHST- 2016/12/28 06:00 [medline]
AID - S0031-9384(16)30100-7 [pii]
AID - 10.1016/j.physbeh.2016.03.016 [doi]
PST - ppublish
SO  - Physiol Behav. 2016 May 15;159:72-9. doi: 10.1016/j.physbeh.2016.03.016. Epub 
      2016 Mar 16.