PMID- 26992959
OWN - NLM
STAT- MEDLINE
DCOM- 20170614
LR  - 20180501
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 164
IP  - Pt B
DP  - 2016 Oct 1
TI  - Molecular mechanism of sweetness sensation.
PG  - 453-463
LID - S0031-9384(16)30101-9 [pii]
LID - 10.1016/j.physbeh.2016.03.015 [doi]
AB  - The current understanding of peripheral molecular events involved in sweet taste 
      sensation in humans is reviewed. Included are discussions of the sweetener 
      receptor T1R2/T1R3, its agonists, antagonists, positive allosteric modulators, 
      the transduction of its activation in taste bud cells and the coding of its 
      signaling to the CNS. Areas of incomplete understanding include 1) signal 
      communication with afferent nerve fibers, 2) contrasting concentration/response 
      (C/R) functions for high-potency (HP) sweeteners (hyperbolic) and carbohydrate 
      (CHO) sweeteners (linear), 3) contrasting temporal profiles for HP sweeteners 
      (delayed onset and extinction) and CHO sweeteners (rapid onset and extinction) 
      and 4) contrasting adaptation behaviors for HP sweeteners (moderate to strong 
      adaptation) and CHO sweeteners (low adaptation). Evidence based on the sweet 
      water aftertastes of several novel sweetness inhibitors is presented providing 
      new support for constitutive activity in T1R2/T1R3. And a model is developed to 
      rationalize the linear C/R functions of CHO sweeteners and hyperbolic C/R 
      functions of HP sweeteners, where the former may activate T1R2/T1R3 by both 
      binding and constitutive activity modulation (i.e., without binding) and the 
      latter activate T1R2/T1R3 only by binding.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - DuBois, Grant E
AU  - DuBois GE
AD  - Almendra (Thailand) Ltd., 215 Quincy Lane, Roswell, GA 30076, USA. Electronic 
      address: grant.dubois@almendra.com.sg.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160315
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (Sweetening Agents)
RN  - 0 (taste receptors, type 1)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Models, Molecular
MH  - Receptors, G-Protein-Coupled/*metabolism
MH  - Sweetening Agents/*chemistry
MH  - Taste/*physiology
OTO - NOTNLM
OT  - Sweetener
OT  - Sweetener positive allosteric modulator
OT  - Sweetener receptor
OT  - Sweetness inhibitor
OT  - Sweetness mechanism and constitutive activity
EDAT- 2016/03/20 06:00
MHDA- 2017/06/15 06:00
CRDT- 2016/03/20 06:00
PHST- 2015/10/15 00:00 [received]
PHST- 2016/03/12 00:00 [revised]
PHST- 2016/03/14 00:00 [accepted]
PHST- 2016/03/20 06:00 [entrez]
PHST- 2016/03/20 06:00 [pubmed]
PHST- 2017/06/15 06:00 [medline]
AID - S0031-9384(16)30101-9 [pii]
AID - 10.1016/j.physbeh.2016.03.015 [doi]
PST - ppublish
SO  - Physiol Behav. 2016 Oct 1;164(Pt B):453-463. doi: 10.1016/j.physbeh.2016.03.015. 
      Epub 2016 Mar 15.