PMID- 26993345
OWN - NLM
STAT- MEDLINE
DCOM- 20170222
LR  - 20220316
IS  - 1432-069X (Electronic)
IS  - 0340-3696 (Linking)
VI  - 308
IP  - 4
DP  - 2016 May
TI  - Intense pulsed light versus photodynamic therapy using liposomal methylene blue 
      gel for the treatment of truncal acne vulgaris: a comparative randomized split 
      body study.
PG  - 263-8
LID - 10.1007/s00403-016-1639-6 [doi]
AB  - Acne vulgaris is an extremely common skin condition. It often leads to negative 
      psychological consequences. Photodynamic therapy (PDT) using intense pulsed light 
      has been introduced for effective treatment of acne. The objective was to study 
      the effect of PDT in truncal acne vulgaris using liposomal methylene blue (LMB) 
      versus IPL alone. Thirty-five patients with varying degrees of acne were treated 
      with topical 0.1 % LMB hydrogel applied on the randomly selected one side of the 
      back, and after 60 min the entire back was exposed to IPL. The procedure was done 
      once weekly for three sessions and patients were re-evaluated 1 month after the 
      third session by two independent dermatologists. Acne severity was graded using 
      the Burton scale. Patient satisfaction using Cardiff Acne Disability Index (CADI) 
      was recorded before and after treatment. On LMB-pretreated side, inflammatory 
      acne lesion counts were significantly decreased by 56.40 % compared with 34.06 % 
      on IPL alone. Marked improvement was seen on LMB-pretreated side in 11.5 % of 
      patients compared with 2.8 % on IPL alone. There was a correlation between CADI 
      score and overall improvement. Our study concluded that LMB-IPL is more effective 
      than IPL alone, safe with tolerable pain in the treatment of acne vulgaris on the 
      back. LMB-IPL is more effective than IPL alone, safe with tolerable pain in the 
      treatment of acne vulgaris on the back.
FAU - Moftah, Nayera Hassan
AU  - Moftah NH
AD  - Dermatology and Venereology Department, Faculty of Medicine for Girls, Al-Azhar 
      University, Cairo, Egypt.
FAU - Ibrahim, Shady Mahmoud
AU  - Ibrahim SM
AUID- ORCID: 0000-0001-7616-267X
AD  - Dermatology and Venereology Department, Faculty of medicine, Al-Azhar University, 
      Cairo, Egypt. Drshadyaly@yahoo.com.
FAU - Wahba, Nadine Hassan
AU  - Wahba NH
AD  - Cairo Hospital for Dermatology and Venereology (Al-Haud Al-Marsoud), Cairo, 
      Egypt.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20160318
PL  - Germany
TA  - Arch Dermatol Res
JT  - Archives of dermatological research
JID - 8000462
RN  - 0 (Photosensitizing Agents)
RN  - 25852-47-5 (Hydrogel, Polyethylene Glycol Dimethacrylate)
RN  - T42P99266K (Methylene Blue)
SB  - IM
MH  - Acne Vulgaris/*drug therapy
MH  - Humans
MH  - Hydrogel, Polyethylene Glycol Dimethacrylate/therapeutic use
MH  - Methylene Blue/*therapeutic use
MH  - Patient Satisfaction
MH  - Photochemotherapy/*methods
MH  - Photosensitizing Agents/*therapeutic use
MH  - Propionibacterium acnes/*drug effects
MH  - Severity of Illness Index
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Acne vulgaris
OT  - IPL
OT  - PDT
EDAT- 2016/03/20 06:00
MHDA- 2017/02/23 06:00
CRDT- 2016/03/20 06:00
PHST- 2015/11/27 00:00 [received]
PHST- 2016/03/08 00:00 [accepted]
PHST- 2016/02/18 00:00 [revised]
PHST- 2016/03/20 06:00 [entrez]
PHST- 2016/03/20 06:00 [pubmed]
PHST- 2017/02/23 06:00 [medline]
AID - 10.1007/s00403-016-1639-6 [pii]
AID - 10.1007/s00403-016-1639-6 [doi]
PST - ppublish
SO  - Arch Dermatol Res. 2016 May;308(4):263-8. doi: 10.1007/s00403-016-1639-6. Epub 
      2016 Mar 18.