PMID- 26995029
OWN - NLM
STAT- MEDLINE
DCOM- 20170316
LR  - 20221207
IS  - 1096-0295 (Electronic)
IS  - 0273-2300 (Linking)
VI  - 77
DP  - 2016 Jun
TI  - Residues and dissipation kinetics of carbendazim and diethofencarb in tomato 
      (Lycopersicon esculentum Mill.) and intake risk assessment.
PG  - 200-5
LID - S0273-2300(16)30056-3 [pii]
LID - 10.1016/j.yrtph.2016.03.012 [doi]
AB  - Dissipation behaviors and residues of carbendazim and diethofencarb in 
      combination in tomato were investigated. The half-lives were 2.1-3.4 days for 
      carbendazim, and 1.8-3.2 days for diethofencarb at a dose of 1.5 times of the 
      recommended dosage. The residues of carbendazim and diethofencarb were below the 
      maximum residue limits (MRLs) in China one day after application of the 
      combination. The ultimate residues were significantly lower than the maximum 
      permissible intake (MPI) in China at the recommended high dose for both child and 
      adult. The values of the maximum dietary exposure for carbendazim and 
      diethofencarb were 0.26 and 0.27 mg per person per day, respectively. The 
      theoretical maximum daily intake (TMDI) values for carbendazim and diethofencarb 
      were 1.5 and 0.5 mg/day, respectively. The dietary exposure was lower than the 
      MPI, which indicates the harvested tomato samples under the experimental 
      conditions (open field) are safe for human consumption at the recommended high 
      dosage of the wettable powder.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Li, Huidong
AU  - Li H
AD  - Institute of Quality Standard and Test Technology for Agro-products, Shandong 
      Academy of Agricultural Sciences, Jinan, Shandong, 250100, China; Shandong 
      Provincial Key Laboratory of Test Technology on Food Quality and Safety, Jinan, 
      Shandong, 250100, China. Electronic address: lihuidong8066@163.com.
FAU - du, Hongxia
AU  - du H
AD  - Institute of Quality Standard and Test Technology for Agro-products, Shandong 
      Academy of Agricultural Sciences, Jinan, Shandong, 250100, China; Shandong 
      Provincial Key Laboratory of Test Technology on Food Quality and Safety, Jinan, 
      Shandong, 250100, China.
FAU - Fang, Liping
AU  - Fang L
AD  - Institute of Quality Standard and Test Technology for Agro-products, Shandong 
      Academy of Agricultural Sciences, Jinan, Shandong, 250100, China; Shandong 
      Provincial Key Laboratory of Test Technology on Food Quality and Safety, Jinan, 
      Shandong, 250100, China.
FAU - Dong, Zhan
AU  - Dong Z
AD  - Institute of Quality Standard and Test Technology for Agro-products, Shandong 
      Academy of Agricultural Sciences, Jinan, Shandong, 250100, China; Shandong 
      Provincial Key Laboratory of Test Technology on Food Quality and Safety, Jinan, 
      Shandong, 250100, China.
FAU - Guan, Shuai
AU  - Guan S
AD  - Institute of Quality Standard and Test Technology for Agro-products, Shandong 
      Academy of Agricultural Sciences, Jinan, Shandong, 250100, China; Shandong 
      Provincial Key Laboratory of Test Technology on Food Quality and Safety, Jinan, 
      Shandong, 250100, China.
FAU - Fan, Wenjing
AU  - Fan W
AD  - Institute of Quality Standard and Test Technology for Agro-products, Shandong 
      Academy of Agricultural Sciences, Jinan, Shandong, 250100, China; Shandong 
      Provincial Key Laboratory of Test Technology on Food Quality and Safety, Jinan, 
      Shandong, 250100, China.
FAU - Chen, Zilei
AU  - Chen Z
AD  - Institute of Quality Standard and Test Technology for Agro-products, Shandong 
      Academy of Agricultural Sciences, Jinan, Shandong, 250100, China; Shandong 
      Provincial Key Laboratory of Test Technology on Food Quality and Safety, Jinan, 
      Shandong, 250100, China. Electronic address: czl7274@163.com.
LA  - eng
PT  - Journal Article
DEP - 20160316
PL  - Netherlands
TA  - Regul Toxicol Pharmacol
JT  - Regulatory toxicology and pharmacology : RTP
JID - 8214983
RN  - 0 (Benzimidazoles)
RN  - 0 (Carbamates)
RN  - 0 (Fungicides, Industrial)
RN  - 0 (Pesticides)
RN  - 0 (Phenylcarbamates)
RN  - 0 (Powders)
RN  - 421BLT77U4 (diethofencarb)
RN  - H75J14AA89 (carbendazim)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Benzimidazoles/adverse effects/*metabolism
MH  - Carbamates/adverse effects/*metabolism
MH  - Child
MH  - China
MH  - Diet
MH  - Environmental Monitoring/methods
MH  - *Food Contamination
MH  - Fruit/metabolism
MH  - Fungicides, Industrial/adverse effects/*metabolism
MH  - Half-Life
MH  - Humans
MH  - Kinetics
MH  - Solanum lycopersicum/*metabolism
MH  - Metabolic Clearance Rate
MH  - Models, Biological
MH  - No-Observed-Adverse-Effect Level
MH  - Pesticides/adverse effects/*metabolism
MH  - Phenylcarbamates/adverse effects/*metabolism
MH  - Powders
MH  - Risk Assessment
OTO - NOTNLM
OT  - Carbendazim
OT  - Diethofencarb
OT  - Dissipation
OT  - Residue
OT  - Risk assessment
EDAT- 2016/03/21 06:00
MHDA- 2017/03/17 06:00
CRDT- 2016/03/21 06:00
PHST- 2015/12/08 00:00 [received]
PHST- 2016/03/14 00:00 [revised]
PHST- 2016/03/15 00:00 [accepted]
PHST- 2016/03/21 06:00 [entrez]
PHST- 2016/03/21 06:00 [pubmed]
PHST- 2017/03/17 06:00 [medline]
AID - S0273-2300(16)30056-3 [pii]
AID - 10.1016/j.yrtph.2016.03.012 [doi]
PST - ppublish
SO  - Regul Toxicol Pharmacol. 2016 Jun;77:200-5. doi: 10.1016/j.yrtph.2016.03.012. 
      Epub 2016 Mar 16.