PMID- 26995199
OWN - NLM
STAT- MEDLINE
DCOM- 20160617
LR  - 20221207
IS  - 1214-6994 (Print)
IS  - 1214-6994 (Linking)
VI  - 117
IP  - 1
DP  - 2016
TI  - High Prevalence of Hypovitaminosis D in Postmenopausal Women with Type 2 Diabetes 
      Mellitus.
PG  - 5-17
LID - 10.14712/23362936.2016.1 [doi]
AB  - The link between vitamin D and type 2 diabetes mellitus (T2DM) is intensively 
      studied. This study aims to define the serum concentration of 25-hydroxyvitamin D 
      (25-OH D) and to investigate the relationship between 25-OH D status, glycated 
      hemoglobin (HbA1c) and body composition in postmenopausal women with T2DM and in 
      non-diabetic controls. In this cross-sectional study, 75 women with T2DM and 32 
      control subjects were selected. Serum 25-OH D, intact parathyroid hormone (PTH), 
      calcium, fasting glucose and HbA1c, were measured. The mean 25-OH D level was 
      21.4+/-11.4 ng/ml (range 4.1-50.7 ng/ml) in diabetic women and 30.3+/-9.4 ng/ml 
      (range 10.8-54.2 ng/ml) in control group (p<0.001). The prevalence of 
      hypovitaminosis D (<30 ng/ml) was higher in vitamin D3 non-supplemented T2DM 
      women (89% vs. 63% controls); the difference diminished in vitamin D3 (500-1000 
      IU per day) supplemented subgroups (45% diabetics vs. 42% controls). In T2DM 
      women, 25-OH D levels were not associated to HbA1c, duration of diabetes, fasting 
      glucose and PTH levels, however, 25-OH D levels negatively associated with body 
      mass index (p=0.011), total body fat mass (p=0.005) and total body lean mass 
      (p=0.004). The prevalence of hypovitaminosis D is higher in non-supplemented 
      postmenopausal women with T2DM than in non-diabetic controls (89% vs. 63%). 
      Obesity is a risk factor for vitamin D insufficiency in T2DM postmenopausal 
      women. Further studies evaluating relationships between fat, muscle, bone and 
      vitamin D metabolism in T2DM patients are warranted.
FAU - Raska, Ivan Jr
AU  - Raska I Jr
AD  - 3rd Department of Medicine - Department of Endocrinology and Metabolism, First 
      Faculty of Medicine, Charles University in Prague and General University Hospital 
      in Prague, Prague, Czech Republic. Ivan.Raska@vfn.cz.
FAU - Raskova, Maria
AU  - Raskova M
AD  - 3rd Department of Medicine - Department of Endocrinology and Metabolism, First 
      Faculty of Medicine, Charles University in Prague and General University Hospital 
      in Prague, Prague, Czech Republic.
FAU - Zikan, Vit
AU  - Zikan V
AD  - 3rd Department of Medicine - Department of Endocrinology and Metabolism, First 
      Faculty of Medicine, Charles University in Prague and General University Hospital 
      in Prague, Prague, Czech Republic.
FAU - Skrha, Jan
AU  - Skrha J
AD  - 3rd Department of Medicine - Department of Endocrinology and Metabolism, First 
      Faculty of Medicine, Charles University in Prague and General University Hospital 
      in Prague, Prague, Czech Republic.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Czech Republic
TA  - Prague Med Rep
JT  - Prague medical report
JID - 101227436
RN  - 0 (Glycated Hemoglobin A)
RN  - 1406-16-2 (Vitamin D)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Absorptiometry, Photon/methods
MH  - Aged
MH  - Body Composition
MH  - Body Mass Index
MH  - Cross-Sectional Studies
MH  - Czech Republic/epidemiology
MH  - *Diabetes Mellitus, Type 2/blood/epidemiology
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Middle Aged
MH  - *Obesity/diagnosis/epidemiology
MH  - Postmenopause/*metabolism
MH  - Prevalence
MH  - Risk Factors
MH  - Vitamin D/analogs & derivatives/blood
MH  - *Vitamin D Deficiency/blood/diagnosis/epidemiology
OTO - NOTNLM
OT  - Body composition
OT  - Hypovitaminosis D
OT  - Parathyroid hormone
OT  - Type 2 diabetes mellitus
OT  - Vitamin D
EDAT- 2016/03/21 06:00
MHDA- 2016/06/18 06:00
CRDT- 2016/03/21 06:00
PHST- 2016/03/21 06:00 [entrez]
PHST- 2016/03/21 06:00 [pubmed]
PHST- 2016/06/18 06:00 [medline]
AID - pmr_2016117010005 [pii]
AID - 10.14712/23362936.2016.1 [doi]
PST - ppublish
SO  - Prague Med Rep. 2016;117(1):5-17. doi: 10.14712/23362936.2016.1.