PMID- 26995228
OWN - NLM
STAT- MEDLINE
DCOM- 20170309
LR  - 20220408
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 92
DP  - 2016 Jun
TI  - In vivo relevant mixed urolithins and ellagic acid inhibit phenotypic and 
      molecular colon cancer stem cell features: A new potentiality for ellagitannin 
      metabolites against cancer.
PG  - 8-16
LID - S0278-6915(16)30074-6 [pii]
LID - 10.1016/j.fct.2016.03.011 [doi]
AB  - Colon cancer stem cells (CSCs) offer a novel paradigm for colorectal cancer (CRC) 
      treatment and dietary polyphenols may contribute to battle these cells. 
      Specifically, polyphenol-derived colon metabolites have the potential to interact 
      with and affect colon CSCs. We herein report the effects against colon CSCs of 
      two mixtures of ellagitannin (ET) metabolites, ellagic acid (EA) and the gut 
      microbiota-derived urolithins (Uro) at concentrations detected in the human colon 
      tissues following the intake of ET-containing products (pomegranate, walnuts). 
      These mixtures reduce phenotypic and molecular features in two models of colon 
      CSCs: Caco-2 cells and primary tumour cells from a patient with CRC. The mixture 
      containing mostly Uro-A (85% Uro-A, 10% Uro-C, 5% EA) was most effective at 
      inhibiting the number and size of colonospheres and aldehyde dehydrogenase 
      activity (ALDH, a marker of chemoresistance) whereas the mixture containing less 
      Uro-A but IsoUro-A and Uro-B (30% Uro-A, 50% IsoUro-A, 10% Uro-B, 5% Uro-C, 5% 
      EA) had some effects on the number and size of colonospheres but not on ALDH. 
      These data support a role for polyphenols metabolites in the control of colon 
      cancer chemoresistance and relapse and encourage the research on the effects of 
      polyphenols against CSCs.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Nunez-Sanchez, Maria Angeles
AU  - Nunez-Sanchez MA
AD  - Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of 
      Food Science and Technology, CEBAS-CSIC, P.O. Box 164, 30100 Campus de Espinardo, 
      Murcia, Spain.
FAU - Karmokar, Ankur
AU  - Karmokar A
AD  - Cancer Chemoprevention Group, Department of Cancer Studies, University of 
      Leicester, Leicester, UK.
FAU - Gonzalez-Sarrias, Antonio
AU  - Gonzalez-Sarrias A
AD  - Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of 
      Food Science and Technology, CEBAS-CSIC, P.O. Box 164, 30100 Campus de Espinardo, 
      Murcia, Spain.
FAU - Garcia-Villalba, Rocio
AU  - Garcia-Villalba R
AD  - Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of 
      Food Science and Technology, CEBAS-CSIC, P.O. Box 164, 30100 Campus de Espinardo, 
      Murcia, Spain.
FAU - Tomas-Barberan, Francisco A
AU  - Tomas-Barberan FA
AD  - Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of 
      Food Science and Technology, CEBAS-CSIC, P.O. Box 164, 30100 Campus de Espinardo, 
      Murcia, Spain.
FAU - Garcia-Conesa, Maria Teresa
AU  - Garcia-Conesa MT
AD  - Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of 
      Food Science and Technology, CEBAS-CSIC, P.O. Box 164, 30100 Campus de Espinardo, 
      Murcia, Spain. Electronic address: mtconesa@cebas.csic.es.
FAU - Brown, Karen
AU  - Brown K
AD  - Cancer Chemoprevention Group, Department of Cancer Studies, University of 
      Leicester, Leicester, UK.
FAU - Espin, Juan Carlos
AU  - Espin JC
AD  - Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of 
      Food Science and Technology, CEBAS-CSIC, P.O. Box 164, 30100 Campus de Espinardo, 
      Murcia, Spain. Electronic address: jcespin@cebas.csic.es.
LA  - eng
GR  - 13101/CRUK_/Cancer Research UK/United Kingdom
GR  - MC_G0802524/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20160316
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Coumarins)
RN  - 0 (Hydrolyzable Tannins)
RN  - 0 (ellagitannin)
RN  - 1143-70-0 (3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one)
RN  - 19YRN3ZS9P (Ellagic Acid)
SB  - IM
MH  - Biomarkers, Tumor/metabolism
MH  - Colonic Neoplasms/*drug therapy/pathology
MH  - Coumarins/*pharmacology
MH  - Drug Therapy, Combination
MH  - Ellagic Acid/*pharmacology
MH  - Humans
MH  - Hydrolyzable Tannins/*metabolism
MH  - Neoplastic Stem Cells/*drug effects/pathology
MH  - Tumor Cells, Cultured
OTO - NOTNLM
OT  - Chemoprevention
OT  - Colon cancer
OT  - Ellagic acid
OT  - Metabotype
OT  - Stem cells
OT  - Urolithins
EDAT- 2016/03/21 06:00
MHDA- 2017/03/10 06:00
CRDT- 2016/03/21 06:00
PHST- 2016/02/12 00:00 [received]
PHST- 2016/03/11 00:00 [revised]
PHST- 2016/03/14 00:00 [accepted]
PHST- 2016/03/21 06:00 [entrez]
PHST- 2016/03/21 06:00 [pubmed]
PHST- 2017/03/10 06:00 [medline]
AID - S0278-6915(16)30074-6 [pii]
AID - 10.1016/j.fct.2016.03.011 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2016 Jun;92:8-16. doi: 10.1016/j.fct.2016.03.011. Epub 2016 
      Mar 16.