PMID- 26996471
OWN - NLM
STAT- MEDLINE
DCOM- 20170201
LR  - 20221207
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 129
IP  - 7
DP  - 2016 Apr 5
TI  - Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese 
      Patients.
PG  - 778-84
LID - 10.4103/0366-6999.178959 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) has traditionally been considered to 
      affect mainly the elderly; however, the age at diagnosis has gradually reduced in 
      recent years. Although the incidence of young-onset T2DM is increasing, it is 
      still not fully clear the onset characteristics and risk factors of early-onset 
      T2DM. The aim of this study was to describe the initiating characteristics of 
      early-onset T2DM in Chinese patients and evaluate the risk factors for diabetes 
      mellitus. METHODS: This cross-sectional controlled study was performed using a 
      questionnaire survey method in outpatients of multiple centers in China. A total 
      of 1545 patients with T2DM with an age at onset of <40 years were included, and 
      the control group consisted of subjects aged <40 years with normal blood glucose 
      level. RESULTS: In patients with young-onset T2DM, the mean age and initial 
      hemoglobin 1Ac at diagnosis were 32.96 +/- 5.40 years and 9.59 +/- 2.71%, 
      respectively. Most of the patients were obese, followed irregular diet pattern 
      and sedentary lifestyle, had life or work pressure, and had a family history of 
      diabetes mellitus. Compared with subjects with normal blood glucose level, 
      logistic regression analysis showed that waist-to-hip ratio (odds ratio [OR] 
      446.99, 95% confidence interval [CI] 42.37-4714.87), family history of diabetes 
      mellitus (OR 23.46, CI 14.47-38.03), dyslipidemia (OR 2.65, CI 1.54-4.56), 
      diastolic blood pressure (OR 1.02, CI 1.00-1.04), and body mass index (OR 0.95, 
      CI 0.92-0.99) are independent factors for early-onset T2DM. CONCLUSIONS: We 
      observed that abdominal obesity, family history of diabetes mellitus, and medical 
      history of hypertension and dyslipidemia are independent risk factors for 
      early-onset T2DM. It is, therefore, necessary to apply early lifestyle 
      intervention in young people with risk of diabetes mellitus.
FAU - Yu, Hui
AU  - Yu H
FAU - Xie, Li-Fang
AU  - Xie LF
FAU - Chen, Kang
AU  - Chen K
FAU - Yang, Gang-Yi
AU  - Yang GY
FAU - Xing, Xiao-Yan
AU  - Xing XY
FAU - Zhao, Jia-Jun
AU  - Zhao JJ
FAU - Hong, Tian-Pei
AU  - Hong TP
FAU - Shan, Zhong-Yan
AU  - Shan ZY
FAU - Li, Hong-Mei
AU  - Li HM
FAU - Chen, Bing
AU  - Chen B
FAU - Tang, Xu-Lei
AU  - Tang XL
FAU - Qi, Ling
AU  - Qi L
FAU - Yang, Jing
AU  - Yang J
FAU - Fang, Yuan
AU  - Fang Y
FAU - Li, Ting
AU  - Li T
FAU - Wang, Shuang-Shuang
AU  - Wang SS
FAU - Liang, Xue
AU  - Liang X
FAU - Yin, Ya-Qi
AU  - Yin YQ
FAU - Mu, Yi-Ming
AU  - Mu YM
AD  - Department of Endocrinology, Chinese People's Liberation Army General Hospital, 
      Beijing 100853, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/*etiology
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Male
MH  - Risk Factors
MH  - Waist-Hip Ratio
PMC - PMC4819296
EDAT- 2016/03/22 06:00
MHDA- 2017/02/02 06:00
PMCR- 2016/04/05
CRDT- 2016/03/22 06:00
PHST- 2016/03/22 06:00 [entrez]
PHST- 2016/03/22 06:00 [pubmed]
PHST- 2017/02/02 06:00 [medline]
PHST- 2016/04/05 00:00 [pmc-release]
AID - ChinMedJ_2016_129_7_778_178959 [pii]
AID - CMJ-129-778 [pii]
AID - 10.4103/0366-6999.178959 [doi]
PST - ppublish
SO  - Chin Med J (Engl). 2016 Apr 5;129(7):778-84. doi: 10.4103/0366-6999.178959.