PMID- 26997259
OWN - NLM
STAT- MEDLINE
DCOM- 20160905
LR  - 20220408
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Linking)
VI  - 585
IP  - 1
DP  - 2016 Jul 1
TI  - The IL6R gene polymorphisms are associated with sIL-6R, IgE and lung function in 
      Chinese patients with asthma.
PG  - 51-57
LID - S0378-1119(16)30196-2 [pii]
LID - 10.1016/j.gene.2016.03.026 [doi]
AB  - BACKGROUND: sIL-6R is involved in a variety of inflammatory diseases. The present 
      study analyzed the potential associations between two IL6R gene polymorphisms 
      (rs2228145 and rs12083537) and asthma in a Han Chinese population. METHODS: A 
      cohort of 394 patients and 395 healthy controls were genotyped to detect the two 
      polymorphisms using SNaPshot. In 66 asthma patients and 49 controls, peripheral 
      eosinophil and serum immunoglobulin E (IgE) levels were determined using a 
      routine blood test, and sIL-6R levels were measured by ELISA. RESULTS: No 
      statistically significant differences were detected between the patients and 
      controls in the distribution of the two independent IL6R polymorphisms (p>0.05). 
      However, rs2228145 C and rs12083537 G were significantly associated with 
      decreased lung function in patients with asthma; the rs2228145 A-C variant was 
      also associated with increased sIL-6R and IgE levels. In addition, sIL-6R levels 
      were positively associated with IgE and inversely associated with lung function 
      in patients with asthma. CONCLUSIONS: Our results provide evidence that rs2228145 
      C and rs12083537 G are associated with poor lung function in patients with 
      asthma. Furthermore, the rs2228145 A-C variant is associated with levels of 
      sIL-6R and IgE.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Wang, Yajun
AU  - Wang Y
AD  - Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, PR 
      China.
FAU - Hu, Huiting
AU  - Hu H
AD  - Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, PR 
      China.
FAU - Wu, Jun
AU  - Wu J
AD  - Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, PR 
      China.
FAU - Zhao, Xuanna
AU  - Zhao X
AD  - Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, PR 
      China.
FAU - Zhen, Yan
AU  - Zhen Y
AD  - Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, PR 
      China.
FAU - Wang, Shaobing
AU  - Wang S
AD  - Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, PR 
      China.
FAU - Li, Wen
AU  - Li W
AD  - Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, PR 
      China.
FAU - Liang, Min
AU  - Liang M
AD  - Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, PR 
      China.
FAU - Wu, Bin
AU  - Wu B
AD  - Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, PR 
      China.. Electronic address: wubin621011@126.com.
FAU - Ma, Guoda
AU  - Ma G
AD  - Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, PR 
      China.. Electronic address: sihan1107@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160318
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (IL6R protein, human)
RN  - 0 (Receptors, Interleukin-6)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Asthma/*genetics
MH  - China
MH  - Eosinophils
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Lung/*physiology
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Receptors, Interleukin-6/*blood/*genetics
MH  - Respiratory Function Tests
OTO - NOTNLM
OT  - Asthma
OT  - IgE
OT  - Polymorphisms
OT  - Rs12083537
OT  - Rs2228145
OT  - sIL-6R
EDAT- 2016/03/22 06:00
MHDA- 2016/09/07 06:00
CRDT- 2016/03/22 06:00
PHST- 2015/09/22 00:00 [received]
PHST- 2016/03/09 00:00 [revised]
PHST- 2016/03/16 00:00 [accepted]
PHST- 2016/03/22 06:00 [entrez]
PHST- 2016/03/22 06:00 [pubmed]
PHST- 2016/09/07 06:00 [medline]
AID - S0378-1119(16)30196-2 [pii]
AID - 10.1016/j.gene.2016.03.026 [doi]
PST - ppublish
SO  - Gene. 2016 Jul 1;585(1):51-57. doi: 10.1016/j.gene.2016.03.026. Epub 2016 Mar 18.