PMID- 26997983
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 11
IP  - 3
DP  - 2016 Mar
TI  - Curcumin alleviates brain edema by lowering AQP4 expression levels in a rat model 
      of hypoxia-hypercapnia-induced brain damage.
PG  - 709-716
AB  - The present study aimed to investigate the therapeutic effects of curcumin (CU) 
      against brain edema in a rat model of hypoxia-hypercapnia (HH)-induced brain 
      damage (HHBD). Male Sprague-Dawley rats were divided into five groups, including 
      a control group and four treatment groups. The rats in the control group were 
      raised under normal laboratory conditions and were injected with water, whereas 
      the rats in the treatment groups were exposed to a low O(2)/high CO(2) 
      environment simulating HH conditions, and were injected with water, CU, dimethyl 
      sulfoxide (solvent control) or monosialoganglioside GM1. After 2 weeks, the 
      morphological characteristics of the brain tissues were analyzed using optical 
      and electron microscopy. In addition, aquaporin (AQP)-4 protein expression levels 
      in brain tissue samples were analyzed using streptavidin-biotin complex 
      immunohistochemistry and western blotting, and mRNA expression levels were 
      detected using reverse transcription-quantitative polymerase chain reaction. 
      Severe brain edema, tissue structure disruption and increased AQP4 expression 
      levels were detected in the brain tissues of the HH rats. Conversely, the rats 
      treated with CU or GM1 exhibited attenuated HHBD-induced brain edema and tissue 
      structure disruption, and decreased mRNA and protein expression levels of AQP4. 
      The results of the present study suggested that CU treatment was able to 
      attenuate HHBD-induced brain edema by downregulating the expression levels of 
      AQP4 in a rat model. Therefore, CU may be considered a potential therapeutic drug 
      for the treatment of patients with brain edema.
FAU - Yu, Lin-Sheng
AU  - Yu LS
AD  - Shanghai Key Lab of Forensic Medicine, Shanghai City West, Shanghai 200063, P.R. 
      China; Xi'an Jiaotong University Health Science Center, School of Forensic 
      Science and Medicine, Xi'an, Shaanxi 710061, P.R. China; Department of Forensic 
      Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325035w; Institute of 
      Forensic Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. 
      China.
FAU - Fan, Yan-Yan
AU  - Fan YY
AD  - Department of Forensic Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 
      325035w; Institute of Forensic Science, Wenzhou Medical University, Wenzhou, 
      Zhejiang 325035, P.R. China.
FAU - Ye, Guanghua
AU  - Ye G
AD  - Department of Forensic Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 
      325035w; Institute of Forensic Science, Wenzhou Medical University, Wenzhou, 
      Zhejiang 325035, P.R. China.
FAU - Li, Junli
AU  - Li J
AD  - Department of Forensic Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 
      325035w; Institute of Forensic Science, Wenzhou Medical University, Wenzhou, 
      Zhejiang 325035, P.R. China.
FAU - Feng, Xiang-Ping
AU  - Feng XP
AD  - Department of Forensic Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 
      325035w; Institute of Forensic Science, Wenzhou Medical University, Wenzhou, 
      Zhejiang 325035, P.R. China.
FAU - Lin, Kezhi
AU  - Lin K
AD  - Department of Forensic Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 
      325035w; Institute of Forensic Science, Wenzhou Medical University, Wenzhou, 
      Zhejiang 325035, P.R. China.
FAU - Dong, Miuwu
AU  - Dong M
AD  - Department of Forensic Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 
      325035w; Institute of Forensic Science, Wenzhou Medical University, Wenzhou, 
      Zhejiang 325035, P.R. China.
FAU - Wang, Zhenyuan
AU  - Wang Z
AD  - Shanghai Key Lab of Forensic Medicine, Shanghai City West, Shanghai 200063, P.R. 
      China; Xi'an Jiaotong University Health Science Center, School of Forensic 
      Science and Medicine, Xi'an, Shaanxi 710061, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20160125
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC4774356
OTO - NOTNLM
OT  - aquaporin-4
OT  - brain edema
OT  - chronic hypoxia-hypercapnia-induced brain damage
OT  - curcumin
EDAT- 2016/03/22 06:00
MHDA- 2016/03/22 06:01
PMCR- 2016/01/25
CRDT- 2016/03/22 06:00
PHST- 2014/10/21 00:00 [received]
PHST- 2015/10/08 00:00 [accepted]
PHST- 2016/03/22 06:00 [entrez]
PHST- 2016/03/22 06:00 [pubmed]
PHST- 2016/03/22 06:01 [medline]
PHST- 2016/01/25 00:00 [pmc-release]
AID - ETM-0-0-3022 [pii]
AID - 10.3892/etm.2016.3022 [doi]
PST - ppublish
SO  - Exp Ther Med. 2016 Mar;11(3):709-716. doi: 10.3892/etm.2016.3022. Epub 2016 Jan 
      25.