PMID- 26998132
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 11
IP  - 3
DP  - 2016 Mar
TI  - A novel IGH@ gene rearrangement associated with CDKN2A/B deletion in young adult 
      B-cell acute lymphoblastic leukemia.
PG  - 2117-2122
AB  - Acquired copy number changes are common in acute leukemia. They are reported as 
      recurrent amplifications or deletions (del), and may be indicative of involvement 
      of oncogenes or tumor suppressor genes in acquired disease, as well as serving as 
      potential biomarkers for prognosis or as targets for molecular therapy. The 
      present study reported a gain of copy number of 14q13 to 14q32, leading to 
      immunoglobulin heavy chain locus splitting in a young adult female. To the best 
      of our knowledge, this rearrangement has not been previously reported in B-cell 
      acute lymphoblastic leukemia (ALL). Low resolution banding cytogenetics performed 
      at the time of diagnosis revealed a normal karyotype. However, retrospective 
      application of fluorescence in situ hybridization (FISH) banding and 
      locus-specific FISH probes, as well as multiplex ligation-dependent probe 
      amplification and high resolution array-comparative genomic hybridization, 
      revealed previously hidden aberrations. Overall, a karyotype of 46, XX, del(9) 
      (p21.3 p21.3),derivative(14) (pter-> q32.33:: q32.33-> q13 ::q32.33-> qter) was 
      determined. The patient was treated according to the Polish Adult Leukemia Group 
      protocol and achieved complete remission. The results of the present study 
      indicate that a favorable prognosis is associated with these aberrations when the 
      aforementioned treatment is administered.
FAU - Othman, Moneeb A K
AU  - Othman MA
AD  - Institute of Human Genetics, Jena University Hospital, Friedrich Schiller 
      University, Jena D-07740, Germany.
FAU - Grygalewicz, Beata
AU  - Grygalewicz B
AD  - Cytogenetic Laboratory, Maria Sklodowska-Curie Memorial Cancer Centre and 
      Institute, Warsaw 02-781, Poland.
FAU - Pienkowska-Grela, Barbara
AU  - Pienkowska-Grela B
AD  - Cytogenetic Laboratory, Maria Sklodowska-Curie Memorial Cancer Centre and 
      Institute, Warsaw 02-781, Poland.
FAU - Rygier, Jolanta
AU  - Rygier J
AD  - Cytogenetic Laboratory, Maria Sklodowska-Curie Memorial Cancer Centre and 
      Institute, Warsaw 02-781, Poland.
FAU - Ejduk, Anna
AU  - Ejduk A
AD  - Department of Hematology, Institute of Hematology and Transfusion Medicine, 
      Warsaw 02-776, Poland.
FAU - Rincic, Martina
AU  - Rincic M
AD  - Institute of Human Genetics, Jena University Hospital, Friedrich Schiller 
      University, Jena D-07740, Germany; Croatian Institute of Brain Research, Zagreb 
      10000, Croatia, Germany.
FAU - Melo, Joana B
AU  - Melo JB
AD  - Laboratory of Cytogenetics and Genomics, Faculty of Medicine, University of 
      Coimbra, Coimbra 3001-401, Portugal; Research Centre for Environment, Genetics 
      and Oncobiology, Faculty of Medicine, University of Coimbra, Coimbra 3001-401, 
      Portugal, Germany.
FAU - Carreira, Isabel M
AU  - Carreira IM
AD  - Laboratory of Cytogenetics and Genomics, Faculty of Medicine, University of 
      Coimbra, Coimbra 3001-401, Portugal; Research Centre for Environment, Genetics 
      and Oncobiology, Faculty of Medicine, University of Coimbra, Coimbra 3001-401, 
      Portugal, Germany.
FAU - Meyer, Britta
AU  - Meyer B
AD  - ZytoVision GmbH, Bremerhaven D-27572, Germany.
FAU - Liehr, Thomas
AU  - Liehr T
AD  - Institute of Human Genetics, Jena University Hospital, Friedrich Schiller 
      University, Jena D-07740, Germany.
LA  - eng
PT  - Journal Article
DEP - 20160129
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC4774591
OTO - NOTNLM
OT  - B-cell acute lymphoblastic leukemia
OT  - array-comparative genomic hybridization
OT  - cyclin-dependent kinase inhibitor 2A/B deletion
OT  - immunoglobulin heavy locus gene rearrangement
OT  - molecular cytogenetics
EDAT- 2016/03/22 06:00
MHDA- 2016/03/22 06:01
PMCR- 2016/01/29
CRDT- 2016/03/22 06:00
PHST- 2015/01/22 00:00 [received]
PHST- 2015/12/10 00:00 [accepted]
PHST- 2016/03/22 06:00 [entrez]
PHST- 2016/03/22 06:00 [pubmed]
PHST- 2016/03/22 06:01 [medline]
PHST- 2016/01/29 00:00 [pmc-release]
AID - OL-0-0-4169 [pii]
AID - 10.3892/ol.2016.4169 [doi]
PST - ppublish
SO  - Oncol Lett. 2016 Mar;11(3):2117-2122. doi: 10.3892/ol.2016.4169. Epub 2016 Jan 
      29.