PMID- 26999419
OWN - NLM
STAT- MEDLINE
DCOM- 20180126
LR  - 20180820
IS  - 1477-2205 (Electronic)
IS  - 1061-5806 (Linking)
VI  - 29
IP  - 6
DP  - 2016 Nov
TI  - Brain-derived neurotrophic factor Val66met polymorphism and plasma levels in road 
      traffic accident survivors.
PG  - 616-29
LID - 10.1080/10615806.2016.1163545 [doi]
AB  - BACKGROUND: Alterations in brain-derived neurotrophic factor (BDNF) expression 
      and release may play a role in the pathogenesis of post-traumatic stress disorder 
      (PTSD). DESIGN: This study evaluated road traffic accident (RTA) survivors to 
      determine whether PTSD and trauma-related factors were associated with plasma 
      BDNF levels and BDNF Val66Met carrier status following RTA exposure. METHODS: One 
      hundred and twenty-three RTA survivors (mean age 33.2 years, SD = 10.6 years; 
      56.9% male) were assessed 10 (SD = 4.9) days after RTA exposure. Acute stress 
      disorder (ASD), as assessed with the Acute Stress Disorder Scale, was present in 
      50 (42.0%) of the participants. Plasma BDNF levels were measured with 
      enzyme-linked immunosorbent assay and BDNF Val66Met genotyping was performed. 
      PTSD, as assessed with the Clinician-Administered PTSD Scale, was present in 10 
      (10.8%) participants at 6 months follow-up. RESULTS: Neither BDNF Val66Met 
      genotype nor plasma BDNF was significantly associated with the presence or 
      severity of ASD or PTSD. Plasma BDNF levels were, however, significantly 
      correlated with the lifetime number of trauma exposures. CONCLUSIONS: In RTA 
      survivors, plasma BDNF levels increased with increasing number of prior trauma 
      exposures. Plasma BDNF may, therefore, be a marker of trauma load.
FAU - van den Heuvel, Leigh
AU  - van den Heuvel L
AD  - a Department of Psychiatry, Faculty of Medicine and Health Sciences , University 
      of Stellenbosch , Cape Town , South Africa.
FAU - Suliman, Sharain
AU  - Suliman S
AD  - a Department of Psychiatry, Faculty of Medicine and Health Sciences , University 
      of Stellenbosch , Cape Town , South Africa.
FAU - Malan-Muller, Stefanie
AU  - Malan-Muller S
AD  - a Department of Psychiatry, Faculty of Medicine and Health Sciences , University 
      of Stellenbosch , Cape Town , South Africa.
AD  - b Division of Molecular Biology and Human Genetics, Faculty of Medicine and 
      Health Sciences , University of Stellenbosch , Cape Town , South Africa.
FAU - Hemmings, Sian
AU  - Hemmings S
AD  - a Department of Psychiatry, Faculty of Medicine and Health Sciences , University 
      of Stellenbosch , Cape Town , South Africa.
AD  - b Division of Molecular Biology and Human Genetics, Faculty of Medicine and 
      Health Sciences , University of Stellenbosch , Cape Town , South Africa.
FAU - Seedat, Soraya
AU  - Seedat S
AD  - a Department of Psychiatry, Faculty of Medicine and Health Sciences , University 
      of Stellenbosch , Cape Town , South Africa.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160329
PL  - England
TA  - Anxiety Stress Coping
JT  - Anxiety, stress, and coping
JID - 9212242
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Accidents, Traffic/*statistics & numerical data
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood/genetics
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Humans
MH  - Male
MH  - Methionine
MH  - Polymorphism, Genetic/*genetics
MH  - Prospective Studies
MH  - Stress Disorders, Post-Traumatic/*blood/*genetics
MH  - Survivors/*statistics & numerical data
MH  - Valine
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor (BDNF)
OT  - Val66met
OT  - acute stress disorder (ASD)
OT  - plasma
OT  - post-traumatic stress disorder (PTSD)
OT  - trauma
EDAT- 2016/03/22 06:00
MHDA- 2018/01/27 06:00
CRDT- 2016/03/22 06:00
PHST- 2016/03/22 06:00 [entrez]
PHST- 2016/03/22 06:00 [pubmed]
PHST- 2018/01/27 06:00 [medline]
AID - 10.1080/10615806.2016.1163545 [doi]
PST - ppublish
SO  - Anxiety Stress Coping. 2016 Nov;29(6):616-29. doi: 10.1080/10615806.2016.1163545. 
      Epub 2016 Mar 29.