PMID- 26999840
OWN - NLM
STAT- MEDLINE
DCOM- 20160621
LR  - 20201209
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 29
IP  - 19
DP  - 2015 Oct
TI  - [The expression and clinical significance of Bax and PHF20 in laryngeal squamous 
      cell carcinoma].
PG  - 1701-5
AB  - OBJECTIVE: To investigate the expression of Bax and PHF20 in laryngeal squamous 
      cell carcinoma (LSCC)and to discuss their relevance and the roles in 
      carcinogenesis and development in LSCC. METHOD: The expressions of Bax and PHF20 
      in the LSCC tissues and normal mucosa tissues adjacent to carcinoma were detected 
      by SP immunohistochemistry assay. The relationship between the expressions of Bax 
      and PHF20 and the clinicopathological characteristics including clinical stage, 
      pathological type, histological grade and lymph node metastasis in LSCC were 
      analyzed according to the clinical data. RESULT: (1) The expressions of Bax and 
      PHF20 were both significantly lower in the LSCC tissue than that in the normal 
      laryngeal tissue (P < 0.01). (2) In clinical stage grouping, there were no 
      statistical differences of the quantity and positive rate of Bax and PHF20 
      expressions among supraglottic, glottic and subglottic LSCC (P > 0.05). In 
      histological differentiation grouping, the quantity and positive rate of Bax and 
      PHF20 expressions decreased significantly in poorly differentiated LSCC compared 
      with the well and moderately differentiated LSCCs (P < 0.01, P < 0.05, 
      respectively). In T stage grouping, the quantity and positive rate of Bax and 
      PHF20 expressions were both significantly higher in T1 + T2 compared with T3 +T4 
      (both P < 0.01). In addition, the quantity and positive rate of Bax and PHF20 
      expressions were both significantly higher in LSCC with lymph node metastasis 
      compared to that without lymph node metastasis (both P < 0.01). CONCLUSION: The 
      lack of Bax and PHF20 might contribute to the carcinogenesis and development in 
      LSCC. The positive expression of Bax and PHF20 maybe relative to T term degree, 
      differentiation degree and lymphamatic metastasis of LSCC.
FAU - Zhang, Chunming
AU  - Zhang C
FAU - Gao, Wei
AU  - Gao W
FAU - Dong, Shubin
AU  - Dong S
FAU - Chen, Ganggang
AU  - Chen G
FAU - Han, Rui
AU  - Han R
FAU - Wen, Shuxin
AU  - Wen S
FAU - Wang, Binquan
AU  - Wang B
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (BAX protein, human)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (PHF20 protein, human)
RN  - 0 (Transcription Factors)
RN  - 0 (bcl-2-Associated X Protein)
SB  - IM
MH  - Antigens, Neoplasm/*metabolism
MH  - Biomarkers, Tumor/*metabolism
MH  - Carcinoma, Squamous Cell/*metabolism
MH  - DNA-Binding Proteins
MH  - Head and Neck Neoplasms/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*metabolism
MH  - Lymphatic Metastasis
MH  - Prognosis
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Transcription Factors
MH  - bcl-2-Associated X Protein/*metabolism
EDAT- 2016/03/24 06:00
MHDA- 2016/06/22 06:00
CRDT- 2016/03/23 06:00
PHST- 2016/03/23 06:00 [entrez]
PHST- 2016/03/24 06:00 [pubmed]
PHST- 2016/06/22 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Oct;29(19):1701-5.