PMID- 27000727
OWN - NLM
STAT- MEDLINE
DCOM- 20160912
LR  - 20210102
IS  - 1532-8686 (Electronic)
IS  - 0037-1963 (Linking)
VI  - 53
IP  - 2
DP  - 2016 Apr
TI  - HLA mismatching as a strategy to reduce relapse after alternative donor 
      transplantation.
PG  - 57-64
LID - S0037-1963(16)00011-1 [pii]
LID - 10.1053/j.seminhematol.2016.01.010 [doi]
AB  - Human leukocyte antigen (HLA) mismatches are targets of alloreactive T cells, 
      mediators of graft-versus-leukemia (GvL) and graft-versus-host disease (GvHD) 
      after alternative donor transplantation. Exploitation of HLA mismatching in order 
      to reduce relapse is hampered by necessary interventions aimed at controlling 
      GvHD on the one hand, and by the possibility of immune escape through selective 
      loss of mismatched HLA in relapsing leukemia on the other. Retrospective studies 
      reporting the impact of HLA mismatches on post-transplant relapse need to be 
      interpreted with caution, due to many confounding factors, including disease and 
      use of T-cell depletion, and to be constantly updated to the rapidly changing 
      clinical protocols. Current evidence suggests similar relapse rates for 8/8, 7/8 
      HLA-matched unrelated, T-cell-replete haploidentical and umbilical cord blood 
      transplantation; however, investigations of locus-specific effects are still 
      scarce in the latter two settings. In unrelated transplantation, a specific role 
      for mismatches at HLA-C and HLA-DPB1, and therein of permissive mismatches 
      defined on the basis of T-cell alloreactivity and/or expression levels, in 
      reducing relapse has been demonstrated in independent studies. This observation 
      suggests new approaches to utilize HLA matching in unrelated donor searches, and 
      the need for further research in the field.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Fleischhauer, Katharina
AU  - Fleischhauer K
AD  - Institute for Experimental Cellular Therapy, University Hospital Essen, Essen, 
      Germany; German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic 
      address: katharina.fleischhauer@uk-essen.de.
FAU - Beelen, Dietrich W
AU  - Beelen DW
AD  - Department for Bone Marrow Transplantation, West-German Cancer Center, University 
      Hospital Essen, Essen, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20160115
PL  - United States
TA  - Semin Hematol
JT  - Seminars in hematology
JID - 0404514
RN  - 0 (Histocompatibility Antigens)
SB  - IM
MH  - Graft vs Host Disease/immunology
MH  - Hematopoietic Stem Cell Transplantation/methods
MH  - Histocompatibility Antigens/*immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Recurrence
MH  - T-Lymphocytes/immunology
OTO - NOTNLM
OT  - Alloreactivity
OT  - Graft-versus-leukemia
OT  - HLA mismatch
OT  - Haploidentical HSCT
OT  - MUD HSCT
OT  - Umbilical cord blood HSCT
EDAT- 2016/03/24 06:00
MHDA- 2016/09/13 06:00
CRDT- 2016/03/23 06:00
PHST- 2016/03/23 06:00 [entrez]
PHST- 2016/03/24 06:00 [pubmed]
PHST- 2016/09/13 06:00 [medline]
AID - S0037-1963(16)00011-1 [pii]
AID - 10.1053/j.seminhematol.2016.01.010 [doi]
PST - ppublish
SO  - Semin Hematol. 2016 Apr;53(2):57-64. doi: 10.1053/j.seminhematol.2016.01.010. 
      Epub 2016 Jan 15.