PMID- 27000728
OWN - NLM
STAT- MEDLINE
DCOM- 20160912
LR  - 20181202
IS  - 1532-8686 (Electronic)
IS  - 0037-1963 (Linking)
VI  - 53
IP  - 2
DP  - 2016 Apr
TI  - Alternative donors: cord blood for adults.
PG  - 65-73
LID - S0037-1963(16)00007-X [pii]
LID - 10.1053/j.seminhematol.2016.01.006 [doi]
AB  - Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment 
      for patients with hematological diseases. The probability of finding a human 
      leukocyte antigen (HLA)- identical donor among family members is around 25% and 
      30% that of having a full matched unrelated donor in the registry. Patients in 
      need may also benefit of a HLA-mismatched HSCT either from an haploidentical 
      donors or from umbilical cord blood (UCB). Much has been learned about UCB 
      transplant (UCBT) since the first human UCBT was performed back in 1988. Cord 
      blood banks have been established worldwide for the collection, cryopreservation, 
      and distribution of UCB for HSCT. Today, a global network of cord blood banks and 
      transplant centers has been established with a large common inventory of more 
      than 650,000 UCB units available, allowing for more than 40,000 UCBT worldwide in 
      children and adults with severe hematological diseases. Several studies have been 
      published on UCBT, assessing risk factors such as cell dose and HLA mismatch. 
      Outcomes of several retrospective comparative studies showed similar results 
      using other stem cell sources both in pediatric and adult setting. New strategies 
      are ongoing to facilitate engraftment and reduce transplant-related mortality. In 
      this issue, we review the current results of UCBT in adults with hematological 
      malignancies and the clinical studies comparing UCBT with other transplant 
      strategies. We provide guidelines for donor algorithm selection in UCBT setting.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Ruggeri, Annalisa
AU  - Ruggeri A
AD  - Service d'Hematologie et Therapie Cellulaire, Hopital Saint Antoine, Eurocord, 
      Hopital Saint Louis, Paris, France. Electronic address: annalisa.ruggeri@aphp.fr.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160115
PL  - United States
TA  - Semin Hematol
JT  - Seminars in hematology
JID - 0404514
SB  - IM
MH  - Adult
MH  - Blood Banks
MH  - *Cord Blood Stem Cell Transplantation
MH  - Graft Survival
MH  - Hematologic Diseases/therapy
MH  - Humans
MH  - Risk Factors
OTO - NOTNLM
OT  - Acute leukemia
OT  - Cord blood transplantation
OT  - Cryopreserved TNC
OT  - HLA
EDAT- 2016/03/24 06:00
MHDA- 2016/09/13 06:00
CRDT- 2016/03/23 06:00
PHST- 2016/03/23 06:00 [entrez]
PHST- 2016/03/24 06:00 [pubmed]
PHST- 2016/09/13 06:00 [medline]
AID - S0037-1963(16)00007-X [pii]
AID - 10.1053/j.seminhematol.2016.01.006 [doi]
PST - ppublish
SO  - Semin Hematol. 2016 Apr;53(2):65-73. doi: 10.1053/j.seminhematol.2016.01.006. 
      Epub 2016 Jan 15.