PMID- 27000729
OWN - NLM
STAT- MEDLINE
DCOM- 20160912
LR  - 20181202
IS  - 1532-8686 (Electronic)
IS  - 0037-1963 (Linking)
VI  - 53
IP  - 2
DP  - 2016 Apr
TI  - Transplantations from HLA-identical siblings versus 10/10 HLA-matched unrelated 
      donors.
PG  - 74-6
LID - S0037-1963(16)00014-7 [pii]
LID - 10.1053/j.seminhematol.2016.01.013 [doi]
AB  - The clinical outcome after allogeneic stem cell transplantation from a human 
      leukocyte antigen (HLA)-matched sibling donor as well as an HLA-matched unrelated 
      donor has clearly improved due in part to the progress made in the domains of 
      HLA-typing techniques. Although HLA-matched sibling transplantation is still held 
      as the "gold standard," transplantation from HLA-A, -B, -C, -DRB1, and 
      -DQB1-matched unrelated donors (so called 10/10) represent the first choice for 
      patients without a suitable related donor. Several studies have shown that 
      unmanipulated marrow transplantation from an HLA allele-matched unrelated donor 
      resulted in similar outcomes to those observed following sibling transplantation. 
      However, incorporating anti-thymocyte globulin (ATG) within graft-versus-host 
      disease (GVHD) prophylaxis should be considered for peripheral blood stem cell 
      grafts in order to decrease the risk of developing chronic GVHD.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Yakoub-Agha, Ibrahim
AU  - Yakoub-Agha I
AD  - LIRIC, INSERM U995, University Lille 2, Lille, France; UAM allo-CSH, University 
      Hospital of Lille, Lille, France. Electronic address: 
      Ibrahim.yakoubagha@chru-lille.fr.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160115
PL  - United States
TA  - Semin Hematol
JT  - Seminars in hematology
JID - 0404514
RN  - 0 (Histocompatibility Antigens)
SB  - IM
MH  - Graft vs Host Disease/immunology
MH  - Histocompatibility Antigens/*immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - *Siblings
MH  - Stem Cell Transplantation
MH  - Treatment Outcome
MH  - *Unrelated Donors
OTO - NOTNLM
OT  - 10/10
OT  - HLA-matched
OT  - Sibling
OT  - Unrelated donor
EDAT- 2016/03/24 06:00
MHDA- 2016/09/13 06:00
CRDT- 2016/03/23 06:00
PHST- 2016/03/23 06:00 [entrez]
PHST- 2016/03/24 06:00 [pubmed]
PHST- 2016/09/13 06:00 [medline]
AID - S0037-1963(16)00014-7 [pii]
AID - 10.1053/j.seminhematol.2016.01.013 [doi]
PST - ppublish
SO  - Semin Hematol. 2016 Apr;53(2):74-6. doi: 10.1053/j.seminhematol.2016.01.013. Epub 
      2016 Jan 15.