PMID- 27000733
OWN - NLM
STAT- MEDLINE
DCOM- 20160912
LR  - 20181202
IS  - 1532-8686 (Electronic)
IS  - 0037-1963 (Linking)
VI  - 53
IP  - 2
DP  - 2016 Apr
TI  - Cord blood versus haploidentical stem cell transplantation for hematological 
      malignancies.
PG  - 98-102
LID - S0037-1963(16)00008-1 [pii]
LID - 10.1053/j.seminhematol.2016.01.007 [doi]
AB  - Umbilical cord blood (UCB) and haploidentical donor stem cell sources represent 
      common alternative donor strategies used when a matched sibling donor (MRD) or 
      matched unrelated donor (MUD) is not available for hematopoietic stem cell 
      transplantation (HSCT). Both donor sources require less stringent human leukocyte 
      antigen (HLA) matching and thereby increase the donor pool for patients without a 
      complete HLA-matched donor. Although a randomized trial comparing these donor 
      sources is ongoing, currently available comparisons rely on observational data 
      and small phase II trials. In hematologic malignancies, both donor sources offer 
      the chance of eradicating disease, albeit with different results for engraftment 
      time, graft failure, graft-versus-host disease (GVHD), transplant-related 
      mortality (TRM), and relapse risk. This review focuses on comparing those 
      outcomes and providing clinicians with evidence to help guide the decision 
      between these alternative donor sources.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Kekre, Natasha
AU  - Kekre N
AD  - Division of Hematology, The Ottawa Hospital, Ottawa, ON, Canada.
FAU - Antin, Joseph H
AU  - Antin JH
AD  - Division of Hematologic Malignancies, Dana Farber Cancer Institute, Boston, MA, 
      USA. Electronic address: jantin@partners.org.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160115
PL  - United States
TA  - Semin Hematol
JT  - Seminars in hematology
JID - 0404514
SB  - IM
MH  - Fetal Blood/*transplantation
MH  - *Graft Rejection
MH  - Graft vs Host Disease/immunology
MH  - Hematologic Neoplasms/immunology/*therapy
MH  - *Hematopoietic Stem Cell Transplantation/methods
MH  - Humans
MH  - Recurrence
OTO - NOTNLM
OT  - Haploidentical
OT  - Transplantation
OT  - Umbilical cord blood
EDAT- 2016/03/24 06:00
MHDA- 2016/09/13 06:00
CRDT- 2016/03/23 06:00
PHST- 2016/03/23 06:00 [entrez]
PHST- 2016/03/24 06:00 [pubmed]
PHST- 2016/09/13 06:00 [medline]
AID - S0037-1963(16)00008-1 [pii]
AID - 10.1053/j.seminhematol.2016.01.007 [doi]
PST - ppublish
SO  - Semin Hematol. 2016 Apr;53(2):98-102. doi: 10.1053/j.seminhematol.2016.01.007. 
      Epub 2016 Jan 15.