PMID- 27000736
OWN - NLM
STAT- MEDLINE
DCOM- 20160912
LR  - 20181202
IS  - 1532-8686 (Electronic)
IS  - 0037-1963 (Linking)
VI  - 53
IP  - 2
DP  - 2016 Apr
TI  - Alternative donor transplants for severe aplastic anemia: current experience.
PG  - 115-9
LID - S0037-1963(16)00003-2 [pii]
LID - 10.1053/j.seminhematol.2016.01.002 [doi]
AB  - Patients with acquired severe aplastic anemia (SAA), who lack a human leukocyte 
      antigen (HLA) identical sibling donor (SIB), have two therapeutic options: 
      immunosuppressive therapy with anti-thymocyte globulin (ATG) and cyclosporine 
      (CsA), or a transplant from an alternative donor. In these patients, the current 
      guidelines of the European Group for Blood and Marrow Transplantation (EBMT) call 
      for a course of ATG + CsA first and transplantation in case of no response. The 
      alternative donor source can be an unrelated donor (UD), a cord blood (CB) unit, 
      or a family mismatched member, in most instances genetically HLA haplo-mismatched 
      (HAPLO). In the present review, we will discuss recent results of transplants 
      from matched UD and SIB donors, with significantly improved outcome, especially 
      with UD in the past decade. We will also be looking at CB transplants, and the 
      problems of limited stem cell dose. Finally HAPLO grafts have been explored in 
      patients lacking or having rejected an unrelated or CB graft: early results seem 
      encouraging, though the procedure should still be considered experimental.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Bacigalupo, Andrea
AU  - Bacigalupo A
AD  - Department of Hematology, Universita' Cattolica del Sacro Cuore, Fondazione 
      Policlinico Universitario Gemelli Roma, Largo Agostino Gemelli 1, Rome, Italy. 
      Electronic address: apbacigalupo@yahoo.com.
FAU - Sica, Simona
AU  - Sica S
AD  - Department of Hematology, Universita' Cattolica del Sacro Cuore, Fondazione 
      Policlinico Universitario Gemelli Roma, Largo Agostino Gemelli 1, Rome, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160115
PL  - United States
TA  - Semin Hematol
JT  - Seminars in hematology
JID - 0404514
RN  - 0 (Histocompatibility Antigens)
SB  - IM
MH  - Anemia, Aplastic/*therapy
MH  - Bone Marrow
MH  - Bone Marrow Transplantation
MH  - Hematopoietic Stem Cell Transplantation/methods
MH  - Histocompatibility Antigens/immunology
MH  - Humans
MH  - Siblings
MH  - Unrelated Donors
OTO - NOTNLM
OT  - Aplastic anemia
OT  - Hematopoietic stem cell transplant
EDAT- 2016/03/24 06:00
MHDA- 2016/09/13 06:00
CRDT- 2016/03/23 06:00
PHST- 2016/03/23 06:00 [entrez]
PHST- 2016/03/24 06:00 [pubmed]
PHST- 2016/09/13 06:00 [medline]
AID - S0037-1963(16)00003-2 [pii]
AID - 10.1053/j.seminhematol.2016.01.002 [doi]
PST - ppublish
SO  - Semin Hematol. 2016 Apr;53(2):115-9. doi: 10.1053/j.seminhematol.2016.01.002. 
      Epub 2016 Jan 15.