PMID- 27002327
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20191210
IS  - 1423-033X (Electronic)
IS  - 0254-4962 (Linking)
VI  - 49
IP  - 2
DP  - 2016
TI  - Psychopathological Symptoms Assessed by a System-Specific Approach Are Related to 
      Global Functioning in Schizophrenic Disorders.
PG  - 77-82
LID - 10.1159/000444505 [doi]
AB  - BACKGROUND: By mostly using a positive-negative approach, several studies have 
      identified factors that influence day-to-day functioning. We applied a different, 
      system-specific approach to expand the knowledge of this issue. SAMPLING AND 
      METHODS: We recruited a sample of 100 inpatients with a DSM-IV diagnosis of 
      schizophrenia or schizoaffective disorder. Psychopathological characteristics 
      were assessed with the Bern Psychopathology Scale (BPS) and functional 
      characteristics with the Global Assessment of Functioning (GAF) scale. Linear 
      regression analyses were performed with the GAF score as the dependent variable 
      and the global values of the BPS subscores as independent variables. The model 
      was controlled for confounding variables. Spearman rank correlation analyses were 
      used to identify associations between the relevant BPS subdomains and global 
      functioning. RESULTS: Higher absolute global values of the BPS domains language 
      (px2009; = x2009;0.038) and motor behavior (px2009; = x2009;0.049) were 
      significantly associated with lower GAF scores. These findings remained stable 
      after adjusting for potential confounding variables. A statistically significant 
      negative correlation was found between both qualitative symptoms (rx2009; = 
      x2009;-0.273, px2009; = x2009;0.006) and indirect signs (rx2009; = x2009;-0.269, 
      px2009; = x2009;0.007) of the language domain and GAF scores. Also, quantitative 
      (rx2009; = x2009;-0.211, px2009; = x2009;0.035) and qualitative symptoms (rx2009; 
      = x2009;-0.214, px2009; = x2009;0.033) in the motor behavior domain were 
      associated with poorer functioning. CONCLUSIONS: A system-specific approach can 
      describe subgroups of patients with poor functioning. Identifying such subgroups 
      could help to utilize targeted treatment opinions in a timely manner. Another 
      goal of future research is to clarify the underlying neurobiological deficits.
CI  - (c) 2016 S. Karger AG, Basel.
FAU - Lang, Fabian U
AU  - Lang FU
AD  - Department of Psychiatry and Psychotherapy II, Ulm University, Gx00FC;nzburg, 
      Germany.
FAU - Muller-Stierlin, Annabel S
AU  - Muller-Stierlin AS
FAU - Walther, Sebastian
AU  - Walther S
FAU - Schulze, Thomas G
AU  - Schulze TG
FAU - Becker, Thomas
AU  - Becker T
FAU - Jager, Markus
AU  - Jager M
LA  - eng
PT  - Journal Article
DEP - 20160323
PL  - Switzerland
TA  - Psychopathology
JT  - Psychopathology
JID - 8401537
SB  - IM
MH  - Adult
MH  - Aged
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - Humans
MH  - Inpatients
MH  - Language
MH  - Male
MH  - Middle Aged
MH  - Outcome Assessment, Health Care
MH  - Psychiatric Status Rating Scales
MH  - Psychopathology/*methods
MH  - Psychotic Disorders/*psychology
MH  - Regression Analysis
MH  - Schizophrenia/*diagnosis
MH  - *Schizophrenic Psychology
EDAT- 2016/03/24 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/03/23 06:00
PHST- 2015/05/11 00:00 [received]
PHST- 2016/02/03 00:00 [accepted]
PHST- 2016/03/23 06:00 [entrez]
PHST- 2016/03/24 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 000444505 [pii]
AID - 10.1159/000444505 [doi]
PST - ppublish
SO  - Psychopathology. 2016;49(2):77-82. doi: 10.1159/000444505. Epub 2016 Mar 23.