PMID- 27003201
OWN - NLM
STAT- MEDLINE
DCOM- 20170713
LR  - 20181113
IS  - 1537-7385 (Electronic)
IS  - 0894-9115 (Print)
IS  - 0894-9115 (Linking)
VI  - 95
IP  - 10
DP  - 2016 Oct
TI  - Determining the Minimal Clinically Important Difference for 6-Minute Walk 
      Distance in Fibromyalgia.
PG  - 738-45
LID - 10.1097/PHM.0000000000000485 [doi]
AB  - OBJECTIVE: The aim of this study was to estimate the minimal clinically important 
      difference (MCID) for 6-min walk distance (6MWD) in patients with fibromyalgia. 
      DESIGN: Data from a recently completed trial that included 187 patients who 
      completed the 6-min walk test, Fibromyalgia Impact Questionnaire (FIQ), and 
      Short-Form 36 (SF36) at 12 and 36 wks were used to examine longitudinal changes 
      in 6MWD. An anchor-based approach that used linear regression analyses was used 
      to determine the MCID for 6MWD, using the total FIQ score (FIQ-Total) and 
      SF36-physical function domain as clinical anchors. RESULTS: The mean (SD) change 
      in 6MWD from baseline to week 36 was 34.4 (65.2) m (P < 0.001). The anchor-based 
      MCIDs for the 6MWD were 156 and 167 m for the FIQ and SF36-physical function 
      domain, respectively. These MCIDs correspond with clinically meaningful 
      improvements in FIQ (14% reduction) and SF36-physical function domain (10-point 
      increase). CONCLUSION: The MCID for 6MWD in patients with fibromyalgia was 156 to 
      167 m. These findings provide the first evidence of the change in 6MWD that is 
      perceived by patients to be clinically meaningful. Further research using other 
      MCID calculation methods is needed to refine estimates of the MCID for 6MWD in 
      patients with fibromyalgia.
FAU - Kaleth, Anthony S
AU  - Kaleth AS
AD  - From the Department of Kinesiology, Indiana University-Purdue University, 
      Indianapolis (ASK); Department of Biostatistics, Indiana University, Indianapolis 
      (JES); and Division of Rheumatology, Department of Internal Medicine, Wake Forest 
      University School of Medicine, Winston-Salem, North Carolina (DCA).
FAU - Slaven, James E
AU  - Slaven JE
FAU - Ang, Dennis C
AU  - Ang DC
LA  - eng
GR  - R01 AR054324/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Am J Phys Med Rehabil
JT  - American journal of physical medicine & rehabilitation
JID - 8803677
SB  - IM
MH  - Adult
MH  - Exercise Test/methods/*statistics & numerical data
MH  - Female
MH  - Fibromyalgia/*physiopathology/therapy
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - *Minimal Clinically Important Difference
MH  - Surveys and Questionnaires
MH  - *Walking
PMC - PMC5831244
MID - NIHMS754059
EDAT- 2016/03/24 06:00
MHDA- 2017/07/14 06:00
PMCR- 2018/03/01
CRDT- 2016/03/23 06:00
PHST- 2016/03/23 06:00 [entrez]
PHST- 2016/03/24 06:00 [pubmed]
PHST- 2017/07/14 06:00 [medline]
PHST- 2018/03/01 00:00 [pmc-release]
AID - 10.1097/PHM.0000000000000485 [doi]
PST - ppublish
SO  - Am J Phys Med Rehabil. 2016 Oct;95(10):738-45. doi: 10.1097/PHM.0000000000000485.