PMID- 27003772
OWN - NLM
STAT- MEDLINE
DCOM- 20160623
LR  - 20191113
IS  - 1233-9687 (Print)
IS  - 1233-9687 (Linking)
VI  - 66
IP  - 4
DP  - 2015 Dec
TI  - Mast cells in systemic and cutaneous lupus erythematosus.
PG  - 397-402
AB  - Mast cells (MCs) are known to be regulators of inflammation and immunity, due to 
      the released mediators and expressed cell surface molecules. Lupus erythematosus 
      (LE) is a group of diseases which can be systemic or limited to the skin. Due to 
      the fact that cytokines and chemokines produced by inflammatory cells contribute 
      to the pathogenesis of LE, we quantified the number of mast cells present in the 
      skin. The aim of the study was to compare the chymase-positive and 
      tryptase-positive mast cell counts within skin biopsies from patients with 
      systemic lupus erythematosus (SLE), discoid lupus erythematosus (DLE) and 
      subacute cutaneous lupus erythematosus (SCLE). The material consisted of 45 skin 
      biopsies: 6 with SLE, 34 with DLE and 5 with SCLE. Chymase- and tryptase-positive 
      cells were stained by immunohistochemistry and counted. The mean count of 
      chymase-positive mast cells was 85.14 hpf for the whole group, 35.83 for SLE, 
      88.48 for DLE and 121.6 for SCLE. The mean count of tryptase-positive cells was 
      120.05 hpf for the entire group, 59.17 for SLE, 126.42 for DLE and 149.8 for 
      SCLE. The differences between groups were significant for chymase- and 
      tryptase-positive cells.
FAU - Kaczmarczyk-Sekula, Karolina
AU  - Kaczmarczyk-Sekula K
AD  - Krzysztof Okon, Department of Pathomorphology, Jagiellonian University Collegium 
      Medicum, Grzegorzecka 16, 31-531 Krakow, Poland, e-mail: mpokon@cyf-kr.edu.pl.
FAU - Dyduch, Grzegorz
AU  - Dyduch G
FAU - Kostanski, Marcin
AU  - Kostanski M
FAU - Wielowieyska-Szybinska, Dorota
AU  - Wielowieyska-Szybinska D
FAU - Szpor, Joanna
AU  - Szpor J
FAU - Bialas, Magdalena
AU  - Bialas M
FAU - Okon, Krzysztof
AU  - Okon K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Poland
TA  - Pol J Pathol
JT  - Polish journal of pathology : official journal of the Polish Society of 
      Pathologists
JID - 9437432
RN  - EC 3.4.21.39 (Chymases)
RN  - EC 3.4.21.59 (Tryptases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biopsy
MH  - Chymases/*metabolism
MH  - Female
MH  - Humans
MH  - Lupus Erythematosus, Discoid/*immunology/pathology
MH  - Lupus Erythematosus, Systemic/*immunology/pathology
MH  - Male
MH  - Mast Cells/*enzymology
MH  - Middle Aged
MH  - Skin/pathology
MH  - Tryptases/*metabolism
MH  - Young Adult
EDAT- 2016/03/24 06:00
MHDA- 2016/06/24 06:00
CRDT- 2016/03/23 06:00
PHST- 2016/03/23 06:00 [entrez]
PHST- 2016/03/24 06:00 [pubmed]
PHST- 2016/06/24 06:00 [medline]
AID - 26724 [pii]
AID - 10.5114/pjp.2015.57253 [doi]
PST - ppublish
SO  - Pol J Pathol. 2015 Dec;66(4):397-402. doi: 10.5114/pjp.2015.57253.