PMID- 27004766
OWN - NLM
STAT- MEDLINE
DCOM- 20170501
LR  - 20170501
IS  - 1468-3083 (Electronic)
IS  - 0926-9959 (Linking)
VI  - 30
IP  - 9
DP  - 2016 Sep
TI  - Chronic urticaria and hormones: Is there a link?
PG  - 1527-30
LID - 10.1111/jdv.13644 [doi]
AB  - BACKGROUND: While the role of oestrogens in bradykinin angioedema (AE) has been 
      clearly demonstrated, scarce data are available about the role of sex hormones in 
      chronic urticaria (CU). OBJECTIVES: To gather information from a population of 
      women with various forms of CU [chronic spontaneous urticaria (CSU), including a 
      subtype of isolated histaminic AE and a classic subtype of association of wheals 
      and AE, and exclusive inducible urticaria (IU)] about the impact of sex hormones 
      and reproductive factors on their symptoms. METHODS: This was a cross-sectional 
      study comprising interviews of 200 women consulting for CU at nine centres 
      throughout France between May and July 2013. The dermatologists filled in an 
      online questionnaire on the impact of reproductive factors (puberty, 
      contraception and pregnancy) and hormonal treatments on the course of CU, 
      including CSU and IU, in the presence of the women. RESULTS: Most of the women 
      did not experience CU before puberty and if so, puberty did not influence the 
      course of CU. Only 16 women had experienced a pregnancy during CU which caused a 
      worsening of symptoms in four. Hormonal contraception was associated with 
      aggravation in a minority of women, mostly women with CSU (10%). Women with 
      isolated histaminic AE did not exhibit any female sex hormone dependency. 
      CONCLUSIONS: It would appear that sex hormones act as a trigger in only a small 
      subset of women with CU. Nevertheless, this should be taken into account to 
      improve patient management.
CI  - (c) 2016 European Academy of Dermatology and Venereology.
FAU - Amsler, E
AU  - Amsler E
AD  - Service de Dermatologie-Allergologie, Hopital Tenon, HUEP, APHP, Paris, France.
AD  - GUS: Groupe Urticaire de la Societe Francaise de Dermatologie, France.
FAU - Augey, F
AU  - Augey F
AD  - GUS: Groupe Urticaire de la Societe Francaise de Dermatologie, France.
AD  - Universite Lyon1, INSERM U1111 - CIRI, Hopitaux de Lyon, CH Lyon-Sud, Lyon, 
      France.
FAU - Soria, A
AU  - Soria A
AD  - Service de Dermatologie-Allergologie, Hopital Tenon, HUEP, APHP, Paris, France.
AD  - GUS: Groupe Urticaire de la Societe Francaise de Dermatologie, France.
AD  - Sorbonne Universites, UPMC Univ Paris 06, Unite Mixte de Recherche de Sante (UMR 
      S) CR7, Centre d'Immunologie et des Maladies Infectieuses - Paris (Cimi-Paris), 
      INSERM U1135, Paris, France.
FAU - Boccon-Gibod, I
AU  - Boccon-Gibod I
AD  - GUS: Groupe Urticaire de la Societe Francaise de Dermatologie, France.
AD  - Clinique Universitaire de Medecine Interne, CHU de Grenoble, Grenoble Cedex, 
      France.
AD  - Centre National de Reference des Angioedemes (CReAK), France.
FAU - Doutre, M S
AU  - Doutre MS
AD  - GUS: Groupe Urticaire de la Societe Francaise de Dermatologie, France.
AD  - Service de Dermatologie, Hopital Saint-Andre, CHU de Bordeaux, Bordeaux, France.
FAU - Mathelier-Fusade, P
AU  - Mathelier-Fusade P
AD  - Service de Dermatologie-Allergologie, Hopital Tenon, HUEP, APHP, Paris, France.
AD  - GUS: Groupe Urticaire de la Societe Francaise de Dermatologie, France.
FAU - Nicolas, J F
AU  - Nicolas JF
AD  - GUS: Groupe Urticaire de la Societe Francaise de Dermatologie, France.
AD  - Universite Lyon1, INSERM U1111 - CIRI, Hopitaux de Lyon, CH Lyon-Sud, Lyon, 
      France.
FAU - Rayson-Peyron, N
AU  - Rayson-Peyron N
AD  - GUS: Groupe Urticaire de la Societe Francaise de Dermatologie, France.
AD  - Centre National de Reference des Angioedemes (CReAK), France.
AD  - Service de Dermatologie, hopital St Eloi, Montpellier Cedex, France.
FAU - Gompel, A
AU  - Gompel A
AD  - GUS: Groupe Urticaire de la Societe Francaise de Dermatologie, France.
AD  - Centre National de Reference des Angioedemes (CReAK), France.
AD  - Unite de Gynecologie Endocrinienne, Universite Paris Descartes, APHP, Port Royal 
      Cochin, Paris, France.
LA  - eng
PT  - Journal Article
DEP - 20160323
PL  - England
TA  - J Eur Acad Dermatol Venereol
JT  - Journal of the European Academy of Dermatology and Venereology : JEADV
JID - 9216037
RN  - 0 (Gonadal Steroid Hormones)
SB  - IM
EIN - J Eur Acad Dermatol Venereol. 2016 Nov;30(11):1992. PMID: 27775215
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Chronic Disease
MH  - Cross-Sectional Studies
MH  - Gonadal Steroid Hormones/*physiology
MH  - Humans
MH  - Middle Aged
MH  - Urticaria/*etiology
MH  - Young Adult
EDAT- 2016/03/24 06:00
MHDA- 2017/05/02 06:00
CRDT- 2016/03/24 06:00
PHST- 2015/10/25 00:00 [received]
PHST- 2016/02/15 00:00 [accepted]
PHST- 2016/03/24 06:00 [entrez]
PHST- 2016/03/24 06:00 [pubmed]
PHST- 2017/05/02 06:00 [medline]
AID - 10.1111/jdv.13644 [doi]
PST - ppublish
SO  - J Eur Acad Dermatol Venereol. 2016 Sep;30(9):1527-30. doi: 10.1111/jdv.13644. 
      Epub 2016 Mar 23.