PMID- 27005015
OWN - NLM
STAT- MEDLINE
DCOM- 20170310
LR  - 20220318
IS  - 1365-229X (Electronic)
IS  - 0009-9260 (Linking)
VI  - 71
IP  - 8
DP  - 2016 Aug
TI  - Assessment of myocardial fibrosis with T1 mapping MRI.
PG  - 768-78
LID - S0009-9260(16)00089-1 [pii]
LID - 10.1016/j.crad.2016.02.013 [doi]
AB  - Myocardial fibrosis can arise from a range of pathological processes and its 
      presence correlates with adverse clinical outcomes. Cardiac magnetic resonance 
      (CMR) can provide a non-invasive assessment of cardiac structure, function, and 
      tissue characteristics, which includes late gadolinium enhancement (LGE) 
      techniques to identify focal irreversible replacement fibrosis with a high degree 
      of accuracy and reproducibility. Importantly the presence of LGE is consistently 
      associated with adverse outcomes in a range of common cardiac conditions; 
      however, LGE techniques are qualitative and unable to detect diffuse myocardial 
      fibrosis, which is an earlier form of fibrosis preceding replacement fibrosis 
      that may be reversible. Novel T1 mapping techniques allow quantitative CMR 
      assessment of diffuse myocardial fibrosis with the two most common measures being 
      native T1 and extracellular volume (ECV) fraction. Native T1 differentiates 
      normal from infarcted myocardium, is abnormal in hypertrophic cardiomyopathy, and 
      may be particularly useful in the diagnosis of Anderson-Fabry disease and 
      amyloidosis. ECV is a surrogate measure of the extracellular space and is 
      equivalent to the myocardial volume of distribution of the gadolinium-based 
      contrast medium. It is reproducible and correlates well with fibrosis on 
      histology. ECV is abnormal in patients with cardiac failure and aortic stenosis, 
      and is associated with functional impairment in these groups. T1 mapping 
      techniques promise to allow earlier detection of disease, monitor disease 
      progression, and inform prognosis; however, limitations remain. In particular, 
      reference ranges are lacking for T1 mapping values as these are influenced by 
      specific CMR techniques and magnetic field strength. In addition, there is 
      significant overlap between T1 mapping values in healthy controls and most 
      disease states, particularly using native T1, limiting the clinical application 
      of these techniques at present.
CI  - Copyright (c) 2016 The Royal College of Radiologists. Published by Elsevier Ltd. 
      All rights reserved.
FAU - Everett, R J
AU  - Everett RJ
AD  - British Heart Foundation/University Centre for Cardiovascular Science, University 
      of Edinburgh, UK. Electronic address: Russell.everett@ed.ac.uk.
FAU - Stirrat, C G
AU  - Stirrat CG
AD  - British Heart Foundation/University Centre for Cardiovascular Science, University 
      of Edinburgh, UK.
FAU - Semple, S I R
AU  - Semple SI
AD  - British Heart Foundation/University Centre for Cardiovascular Science, University 
      of Edinburgh, UK; Clinical Research Imaging Centre, University of Edinburgh, UK.
FAU - Newby, D E
AU  - Newby DE
AD  - British Heart Foundation/University Centre for Cardiovascular Science, University 
      of Edinburgh, UK; Clinical Research Imaging Centre, University of Edinburgh, UK.
FAU - Dweck, M R
AU  - Dweck MR
AD  - British Heart Foundation/University Centre for Cardiovascular Science, University 
      of Edinburgh, UK.
FAU - Mirsadraee, S
AU  - Mirsadraee S
AD  - British Heart Foundation/University Centre for Cardiovascular Science, University 
      of Edinburgh, UK; Clinical Research Imaging Centre, University of Edinburgh, UK.
LA  - eng
GR  - FS/14/78/31020/BHF_/British Heart Foundation/United Kingdom
GR  - G0701127/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Review
DEP - 20160319
PL  - England
TA  - Clin Radiol
JT  - Clinical radiology
JID - 1306016
SB  - IM
CIN - Clin Radiol. 2016 Dec;71(12 ):1309-1310. PMID: 27733276
MH  - Cardiomyopathies/*diagnostic imaging/*pathology
MH  - Fibrosis
MH  - Heart/*diagnostic imaging
MH  - Image Enhancement/*methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Myocardium/*pathology
EDAT- 2016/03/24 06:00
MHDA- 2017/03/11 06:00
CRDT- 2016/03/24 06:00
PHST- 2015/11/10 00:00 [received]
PHST- 2016/01/15 00:00 [revised]
PHST- 2016/02/09 00:00 [accepted]
PHST- 2016/03/24 06:00 [entrez]
PHST- 2016/03/24 06:00 [pubmed]
PHST- 2017/03/11 06:00 [medline]
AID - S0009-9260(16)00089-1 [pii]
AID - 10.1016/j.crad.2016.02.013 [doi]
PST - ppublish
SO  - Clin Radiol. 2016 Aug;71(8):768-78. doi: 10.1016/j.crad.2016.02.013. Epub 2016 
      Mar 19.