PMID- 27006962 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20160323 LR - 20201001 IS - 2328-8957 (Print) IS - 2328-8957 (Electronic) IS - 2328-8957 (Linking) VI - 3 IP - 1 DP - 2016 Jan TI - Acute Cryptococcal Immune Reconstitution Inflammatory Syndrome in a Patient on Natalizumab. PG - ofw038 LID - 10.1093/ofid/ofw038 [doi] LID - ofw038 AB - Presented is the first case of acute immune reconstitution inflammatory syndrome (IRIS)-associated cryptococcal meningoencephalitis in a patient on natalizumab for multiple sclerosis. The patient developed acute cerebral edema after initiation of amphotericin B. We propose several mechanisms that explain the acuity of IRIS in this specific patient population and suggest possible therapies. FAU - Gundacker, Nathan D AU - Gundacker ND AD - Department of Medicine, Division of Infectious Diseases. FAU - Jordan, Stephen J AU - Jordan SJ AD - Department of Medicine, Division of Infectious Diseases. FAU - Jones, Benjamin A AU - Jones BA AD - Departments of Neurology. FAU - Drwiega, Joseph C AU - Drwiega JC AD - Pathology , University of Alabama at Birmingham. FAU - Pappas, Peter G AU - Pappas PG AD - Department of Medicine, Division of Infectious Diseases. LA - eng PT - Journal Article DEP - 20160217 PL - United States TA - Open Forum Infect Dis JT - Open forum infectious diseases JID - 101637045 PMC - PMC4800467 OTO - NOTNLM OT - Cryptococcus OT - IRIS OT - fungal OT - meningitis OT - natalizumab EDAT- 2016/03/24 06:00 MHDA- 2016/03/24 06:01 PMCR- 2016/02/17 CRDT- 2016/03/24 06:00 PHST- 2015/12/10 00:00 [received] PHST- 2016/02/11 00:00 [accepted] PHST- 2016/03/24 06:00 [entrez] PHST- 2016/03/24 06:00 [pubmed] PHST- 2016/03/24 06:01 [medline] PHST- 2016/02/17 00:00 [pmc-release] AID - ofw038 [pii] AID - 10.1093/ofid/ofw038 [doi] PST - epublish SO - Open Forum Infect Dis. 2016 Feb 17;3(1):ofw038. doi: 10.1093/ofid/ofw038. eCollection 2016 Jan.