PMID- 27008315
OWN - NLM
STAT- MEDLINE
DCOM- 20180116
LR  - 20180914
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 44
IP  - 4
DP  - 2016 Oct
TI  - Myocardial extracellular volume fraction measurement in chronic total coronary 
      occlusion: Association with myocardial injury, angiographic collateral flow, and 
      functional recovery.
PG  - 972-82
LID - 10.1002/jmri.25235 [doi]
AB  - PURPOSE: To investigate whether myocardial extracellular volume fraction (ECV) 
      measurement by cardiac MR is indicative of myocardial injury, angiographic 
      collateral flow, and functional recovery in patients with chronic total coronary 
      occlusion (CTO). MATERIALS AND METHODS: A total of 50 CTO patients undergoing 1.5 
      Tesla MR were prospectively enrolled, and 28 underwent a second MR 6 months after 
      revascularization. T1-mapping based indices, including pre- and postcontrast T1 
      values and ECV, were obtained from infarcted and non-infarcted myocardium, 
      myocardial segments, and coronary territory. The severity of myocardial injury 
      was rated by transmurality extent of infarction (TEI) and regional wall motion 
      abnormalities (RWMA) score. Angiographic collateral flow was evaluated using 
      Rentrop classification. Improvement in segmental wall motion at 6 months was also 
      assessed. RESULTS: ECV and postcontrast T1 value significantly outperformed 
      precontrast T1 value for identifying myocardial infarction (area under the 
      receiver operating characteristic curve [AUC]: 0.998 and 0.953 versus 0.824, all 
      P < 0.02). Myocardial ECV was strongly correlated with TEI (P = 0.000), RWMA 
      score (P = 0.000), and collateral classification (P = 0.007 for left anterior 
      descending artery [LAD] territory, P = 0.001 for non-LAD territory). Furthermore, 
      the likelihood of functional recovery was better predicted by ECV than by late 
      gadolinium enhancement (LGE) (AUC: 0.76 versus 0.68, P < 0.02). CONCLUSION: 
      Myocardial ECV may be a useful surrogate to assess myocardial injury and 
      angiographic collateral flow in CTO, and ECV provides incremental value to LGE in 
      assessing functional recovery after revascularization. J. MAGN. RESON. IMAGING 
      2016;44:972-982.
CI  - (c) 2016 International Society for Magnetic Resonance in Medicine.
FAU - Chen, Yin-Yin
AU  - Chen YY
AD  - Department of Radiology, Zhongshan Hospital, Fudan University, Department of 
      Medical Imaging, Shanghai Medical school, Fudan University and Shanghai Institute 
      of Medical Imaging, Shanghai, China.
FAU - Ren, Dao-Yuan
AU  - Ren DY
AD  - Department of Cardiology, Zhongshan Hospital, Fudan University and Shanghai 
      Institute of Cardiovascular Diseases, Shanghai, China.
FAU - Zeng, Meng-Su
AU  - Zeng MS
AD  - Department of Radiology, Zhongshan Hospital, Fudan University, Department of 
      Medical Imaging, Shanghai Medical school, Fudan University and Shanghai Institute 
      of Medical Imaging, Shanghai, China.
FAU - Yang, Shan
AU  - Yang S
AD  - Department of Radiology, Zhongshan Hospital, Fudan University, Department of 
      Medical Imaging, Shanghai Medical school, Fudan University and Shanghai Institute 
      of Medical Imaging, Shanghai, China.
FAU - Yun, Hong
AU  - Yun H
AD  - Department of Radiology, Zhongshan Hospital, Fudan University, Department of 
      Medical Imaging, Shanghai Medical school, Fudan University and Shanghai Institute 
      of Medical Imaging, Shanghai, China.
FAU - Fu, Cai-Xia
AU  - Fu CX
AD  - Siemens Shenzhen Magnetic Resonance, Shenzhen, China.
FAU - Ge, Jun-Bo
AU  - Ge JB
AD  - Department of Cardiology, Zhongshan Hospital, Fudan University and Shanghai 
      Institute of Cardiovascular Diseases, Shanghai, China.
FAU - Jin, Hang
AU  - Jin H
AD  - Department of Radiology, Zhongshan Hospital, Fudan University, Department of 
      Medical Imaging, Shanghai Medical school, Fudan University and Shanghai Institute 
      of Medical Imaging, Shanghai, China. jin.hang@outlook.com.
FAU - Qian, Ju-Ying
AU  - Qian JY
AD  - Department of Cardiology, Zhongshan Hospital, Fudan University and Shanghai 
      Institute of Cardiovascular Diseases, Shanghai, China.
FAU - Zhang, Wei-Guo
AU  - Zhang WG
AD  - Department of Radiology, The First Affiliated Hospital of Soochow University, 
      Suzhou, Jiangsu, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160323
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Flow Velocity
MH  - Cardiac Imaging Techniques/methods
MH  - *Coronary Circulation
MH  - Coronary Occlusion/complications/*diagnostic imaging/*physiopathology
MH  - Extracellular Fluid/*diagnostic imaging
MH  - Female
MH  - Heart Injuries/*diagnostic imaging/etiology/*physiopathology
MH  - Humans
MH  - Image Interpretation, Computer-Assisted/methods
MH  - Imaging, Three-Dimensional/methods
MH  - Magnetic Resonance Angiography/*methods
MH  - Male
MH  - Middle Aged
MH  - Recovery of Function
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
OTO - NOTNLM
OT  - T1-mapping
OT  - cardiac
OT  - chronic total coronary occlusion
OT  - extracellular volume fraction
OT  - magnetic resonance imaging
EDAT- 2016/03/24 06:00
MHDA- 2018/01/18 06:00
CRDT- 2016/03/24 06:00
PHST- 2016/01/25 00:00 [received]
PHST- 2016/02/28 00:00 [accepted]
PHST- 2016/03/24 06:00 [entrez]
PHST- 2016/03/24 06:00 [pubmed]
PHST- 2018/01/18 06:00 [medline]
AID - 10.1002/jmri.25235 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2016 Oct;44(4):972-82. doi: 10.1002/jmri.25235. Epub 2016 
      Mar 23.