PMID- 27008592
OWN - NLM
STAT- MEDLINE
DCOM- 20171004
LR  - 20211204
IS  - 1932-846X (Electronic)
IS  - 1932-8451 (Print)
IS  - 1932-8451 (Linking)
VI  - 76
IP  - 12
DP  - 2016 Dec
TI  - mTOR kinase is needed for the development and stabilization of dendritic arbors 
      in newly born olfactory bulb neurons.
PG  - 1308-1327
LID - 10.1002/dneu.22392 [doi]
AB  - Neurogenesis is the process of neuron generation, which occurs not only during 
      embryonic development but also in restricted niches postnatally. One such region 
      is called the subventricular zone (SVZ), which gives rise to new neurons in the 
      olfactory bulb (OB). Neurons that are born postnatally migrate through more 
      complex territories and integrate into fully functional circuits. Therefore, 
      differences in the differentiation of embryonic and postnatally born neurons may 
      exist. Dendritogenesis is an important process for the proper formation of future 
      neuronal circuits. Dendritogenesis in embryonic neurons cultured in vitro was 
      shown to depend on the mammalian target of rapamycin (mTOR). Still unknown, 
      however, is whether mTOR could regulate the dendritic arbor morphology of 
      SVZ-derived postnatal OB neurons under physiological conditions in vivo. The 
      present study used in vitro cultured and differentiated SVZ-derived neural 
      progenitors and found that both mTOR complex 1 and mTOR complex 2 were required 
      for the dendritogenesis of SVZ-derived neurons. Furthermore, using a combination 
      of in vivo electroporation of neural stem cells in the SVZ and genetic and 
      pharmacological inhibition of mTOR, it was found that mTOR was crucial for the 
      growth of basal and apical dendrites in postnatally born OB neurons under 
      physiological conditions and contributed to the stabilization of their basal 
      dendrites. (c) 2016 Wiley Periodicals, Inc. Develop Neurobiol 76: 1308-1327, 2016.
CI  - (c) 2016 The Authors Developmental Neurobiology Published by Wiley Periodicals, 
      Inc.
FAU - Skalecka, Agnieszka
AU  - Skalecka A
AD  - International Institute of Molecular and Cell Biology, 4 Ks. Trojdena St, Warsaw, 
      02-109, Poland.
FAU - Liszewska, Ewa
AU  - Liszewska E
AD  - International Institute of Molecular and Cell Biology, 4 Ks. Trojdena St, Warsaw, 
      02-109, Poland.
FAU - Bilinski, Robert
AU  - Bilinski R
AD  - Departement De Mathematiques, College Montmorency, 475 Boulevard De L'Avenir, 
      Laval, Quebec, H7N 5H9, Canada.
FAU - Gkogkas, Christos
AU  - Gkogkas C
AD  - Patrick Wild Centre and Centre for Integrative Physiology, University of 
      Edinburgh, Hugh Robson Building George Square, Edinburgh, EH8 9XD, United 
      Kingdom.
FAU - Khoutorsky, Arkady
AU  - Khoutorsky A
AD  - Department of Biochemistry, Goodman Cancer Research Centre, McGill University, 
      1160 Pine Avenue West, Montreal, Quebec, H3A 1A3, Canada.
FAU - Malik, Anna R
AU  - Malik AR
AD  - International Institute of Molecular and Cell Biology, 4 Ks. Trojdena St, Warsaw, 
      02-109, Poland.
FAU - Sonenberg, Nahum
AU  - Sonenberg N
AD  - Department of Biochemistry, Goodman Cancer Research Centre, McGill University, 
      1160 Pine Avenue West, Montreal, Quebec, H3A 1A3, Canada.
FAU - Jaworski, Jacek
AU  - Jaworski J
AD  - International Institute of Molecular and Cell Biology, 4 Ks. Trojdena St, Warsaw, 
      02-109, Poland.
LA  - eng
PT  - Journal Article
DEP - 20160407
PL  - United States
TA  - Dev Neurobiol
JT  - Developmental neurobiology
JID - 101300215
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Cell Differentiation/physiology
MH  - Cell Movement/physiology
MH  - Cerebral Ventricles/physiology
MH  - Mice
MH  - Neural Stem Cells/cytology/*metabolism
MH  - Neurogenesis/*physiology
MH  - Neurons/cytology/*metabolism
MH  - Olfactory Bulb/*growth & development
MH  - TOR Serine-Threonine Kinases/*metabolism
PMC - PMC5132010
OTO - NOTNLM
OT  - dendritogenesis
OT  - in vivo electroporation
OT  - mTOR
OT  - olfactory bulb
OT  - postnatal neurogenesis
EDAT- 2016/03/24 06:00
MHDA- 2017/10/05 06:00
PMCR- 2016/12/01
CRDT- 2016/03/24 06:00
PHST- 2015/08/24 00:00 [received]
PHST- 2016/02/05 00:00 [revised]
PHST- 2016/03/21 00:00 [accepted]
PHST- 2016/03/24 06:00 [pubmed]
PHST- 2017/10/05 06:00 [medline]
PHST- 2016/03/24 06:00 [entrez]
PHST- 2016/12/01 00:00 [pmc-release]
AID - DNEU22392 [pii]
AID - 10.1002/dneu.22392 [doi]
PST - ppublish
SO  - Dev Neurobiol. 2016 Dec;76(12):1308-1327. doi: 10.1002/dneu.22392. Epub 2016 Apr 
      7.