PMID- 27010146
OWN - NLM
STAT- MEDLINE
DCOM- 20161111
LR  - 20181202
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 20
IP  - 5
DP  - 2016 Mar
TI  - The retinal nerve fiber layer, choroidal thickness, and central macular thickness 
      in morbid obesity: an evaluation using spectral-domain optical coherence 
      tomography.
PG  - 886-91
LID - 10433 [pii]
AB  - OBJECTIVE: To assess the effect of morbid obesity on retinal nerve fiber layer 
      (RNFL) thickness, central macular thickness (CMT), retinal ganglion cell (RGC), 
      choroidal thickness (CT), central corneal thickness (CCT), and intraocular 
      pressure (IOP). PATIENTS AND METHODS: Sixty-seven patients defined as having 
      morbid or class III obesity (BMI >/= 40; Group 1) scheduled to undergo sleeve 
      gastrectomy surgery and 29 nonobese patients (BMI 18.50-24.99; Group 2) underwent 
      complete ophthalmic examination for measurement of IOP, CT, RNFL thickness, CMT, 
      RGC, and CCT. RNFL thickness, CMT, and RGC were measured using spectral-domain 
      optical coherence tomography (SD-OCT). CT measurement was performed using the 
      enhanced depth imaging technique of the SD-OCT. The group data were analyzed and 
      compared using the Mann-Whitney U test and Student's t-test. The relationship 
      between the clinical ocular variables and obesity was analyzed using the 
      Spearman's rank correlation test. RESULTS: The mean IOP and CCT of Group 1 were 
      found to be significantly higher (p < 0.001) and the mean RNFL, RGC, and CT 
      significantly lower (p < 0.05) than those of Group 2. While Group 2 was found to 
      have a slightly larger cup-to-disc ratio and Group 1 to have a thinner CMT, the 
      differences between Groups 1 and 2 regarding these variables were not found to be 
      statistically significant (p = 0.322 and p = 0.072, respectively). The results of 
      Spearmen correlation analysis indicated the existence of a moderately positive 
      correlation between IOP and BMI (p < 0.001; r = 0.5-0.6). CONCLUSIONS: We have 
      demonstrated by SD-OCT that morbid obesity may have a significant influence on 
      RNFL, RGC, and CT. Morbid obesity may induce inflammatory, hormonal, and 
      metabolic changes.
FAU - Dogan, B
AU  - Dogan B
AD  - Department of Ophthalmology, Antalya Training and Research Hospital, Antalya, 
      Turkey. bernadoga3@hotmail.com.
FAU - Kazim Erol, M
AU  - Kazim Erol M
FAU - Dogan, U
AU  - Dogan U
FAU - Habibi, M
AU  - Habibi M
FAU - Bulbuller, N
AU  - Bulbuller N
FAU - Turgut Coban, D
AU  - Turgut Coban D
FAU - Bulut, M
AU  - Bulut M
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Choroid/*pathology
MH  - Eye Diseases/complications/*diagnosis/pathology
MH  - Female
MH  - Humans
MH  - Intraocular Pressure
MH  - Macula Lutea/*pathology
MH  - Male
MH  - Middle Aged
MH  - Obesity, Morbid/complications/*pathology
MH  - Organ Size
MH  - Retina/pathology
MH  - Retinal Ganglion Cells/pathology
MH  - Retinal Neurons/*pathology
MH  - *Tomography, Optical Coherence
EDAT- 2016/03/25 06:00
MHDA- 2016/11/12 06:00
CRDT- 2016/03/25 06:00
PHST- 2016/03/25 06:00 [entrez]
PHST- 2016/03/25 06:00 [pubmed]
PHST- 2016/11/12 06:00 [medline]
AID - 10433 [pii]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2016 Mar;20(5):886-91.