PMID- 27010628
OWN - NLM
STAT- MEDLINE
DCOM- 20170223
LR  - 20170817
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 80
IP  - 5
DP  - 2016 Apr 25
TI  - Characterization of Compacted Myocardial Abnormalities by Cardiac Magnetic 
      Resonance With Native T1 Mapping in Left Ventricular Non-Compaction Patients　- A 
      Comparison With Late Gadolinium Enhancement.
PG  - 1210-6
LID - 10.1253/circj.CJ-15-1269 [doi]
AB  - BACKGROUND: Native T1 mapping is an emerging cardiac magnetic resonance technique 
      for quantitative evaluation of cardiomyopathies. This study aimed to investigate 
      the usefulness of native T1 mapping in characterizing myocardial abnormalities in 
      left ventricular non-compaction (LVNC) by comparing it with late gadolinium 
      enhancement (LGE). METHODS AND RESULTS: The study group of 31 LVNC patients and 8 
      normal controls underwent cardiovascular magnetic resonance to acquire the native 
      T1 maps and LGE images. Of the 31 LVNC patients, 14 had LGE. The mean native T1 
      value of the normal controls, LGE(-) and LGE(+) patients was 1,098.8+/-40.8 ms, 
      1140.6+/-32.8 ms, and 1181.4+/-53.7 ms, respectively. Significant differences were 
      found in native T1 between any 2 groups (F=9.74, P<0.001). In discriminating the 
      presence of LGE in LVNC patients, the odds ratio and corresponding 95% confidence 
      interval (CI) of native T1 were, respectively, 2.966 (95% CI: 1.123-7.835, 
      P=0.028) and 4.348 (95% CI: 1.155-16.363, P=0.030) before and after adjusting for 
      confounding factors with an increment of 1 standard deviation. CONCLUSIONS: The 
      finding that LGE(-) patients had elevated native T1 compared with normal controls 
      suggested native T1 mapping can be used earlier than LGE imaging to detect 
      myocardial fibrosis in LVNC patients. Furthermore, higher native T1 values in 
      LGE(+) patients than in the LGE(-) group suggested native T1 mapping is more 
      sensitive than LGE imaging for identifying myocardial fibrosis in LVNC patients. 
      (Circ J 2016; 80: 1210-1216).
FAU - Zhou, Hongmei
AU  - Zhou H
AD  - Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy 
      of Medical Sciences & Peking Union Medical College.
FAU - Lin, Xue
AU  - Lin X
FAU - Fang, Ligang
AU  - Fang L
FAU - Zhao, Xihai
AU  - Zhao X
FAU - Ding, Haiyan
AU  - Ding H
FAU - Chen, Wei
AU  - Chen W
FAU - Xu, Ruiyi
AU  - Xu R
FAU - Bai, Xiaoyin
AU  - Bai X
FAU - Wang, Yining
AU  - Wang Y
FAU - Fang, Quan
AU  - Fang Q
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20160323
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Fibrosis/diagnostic imaging
MH  - *Gadolinium
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Myocardium/*pathology
MH  - Time Factors
MH  - *Ventricular Function, Left
EDAT- 2016/03/25 06:00
MHDA- 2017/02/24 06:00
CRDT- 2016/03/25 06:00
PHST- 2016/03/25 06:00 [entrez]
PHST- 2016/03/25 06:00 [pubmed]
PHST- 2017/02/24 06:00 [medline]
AID - 10.1253/circj.CJ-15-1269 [doi]
PST - ppublish
SO  - Circ J. 2016 Apr 25;80(5):1210-6. doi: 10.1253/circj.CJ-15-1269. Epub 2016 Mar 
      23.