PMID- 27010777
OWN - NLM
STAT- MEDLINE
DCOM- 20170220
LR  - 20220408
IS  - 1437-4331 (Electronic)
IS  - 1434-6621 (Linking)
VI  - 54
IP  - 8
DP  - 2016 Aug 1
TI  - Performance of electrolyte measurements assessed by a trueness verification 
      program.
PG  - 1319-27
LID - 10.1515/cclm-2015-1110 [doi]
AB  - BACKGROUND: In this study, we analyzed frozen sera with known commutabilities for 
      standardization of serum electrolyte measurements in China. METHODS: Fresh frozen 
      sera were sent to 187 clinical laboratories in China for measurement of four 
      electrolytes (sodium, potassium, calcium, and magnesium). Target values were 
      assigned by two reference laboratories. Precision (CV), trueness (bias), and 
      accuracy [total error (TEa)] were used to evaluate measurement performance, and 
      the tolerance limit derived from the biological variation was used as the 
      evaluation criterion. RESULTS: About half of the laboratories used a homogeneous 
      system (same manufacturer for instrument, reagent and calibrator) for calcium and 
      magnesium measurement, and more than 80% of laboratories used a homogeneous 
      system for sodium and potassium measurement. More laboratories met the tolerance 
      limit of imprecision (coefficient of variation [CVa]) than the tolerance limits 
      of trueness (biasa) and TEa. For sodium, calcium, and magnesium, the minimal 
      performance criterion derived from biological variation was used, and the pass 
      rates for total error were approximately equal to the bias (<50%). For potassium, 
      the pass rates for CV and TE were more than 90%. Compared with the non 
      homogeneous system, the homogeneous system was superior for all three quality 
      specifications. CONCLUSIONS: The use of commutable proficiency testing/external 
      quality assessment (PT/EQA) samples with values assigned by reference methods can 
      monitor performance and provide reliable data for improving the performance of 
      laboratory electrolyte measurement. The homogeneous systems were superior to the 
      non homogeneous systems, whereas accuracy of assigned values of calibrators and 
      assay stability remained challenges.
FAU - Ge, Menglei
AU  - Ge M
FAU - Zhao, Haijian
AU  - Zhao H
FAU - Yan, Ying
AU  - Yan Y
FAU - Zhang, Tianjiao
AU  - Zhang T
FAU - Zeng, Jie
AU  - Zeng J
FAU - Zhou, Weiyan
AU  - Zhou W
FAU - Wang, Yufei
AU  - Wang Y
FAU - Meng, Qinghui
AU  - Meng Q
FAU - Zhang, Chuanbao
AU  - Zhang C
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
RN  - 0 (Electrolytes)
RN  - 9NEZ333N27 (Sodium)
RN  - I38ZP9992A (Magnesium)
RN  - RWP5GA015D (Potassium)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Calcium/blood
MH  - China
MH  - Clinical Laboratory Techniques/*standards
MH  - Electrolytes/*blood
MH  - Humans
MH  - Magnesium/blood
MH  - Potassium/blood
MH  - Sodium/blood
EDAT- 2016/03/25 06:00
MHDA- 2017/08/18 06:00
CRDT- 2016/03/25 06:00
PHST- 2015/11/12 00:00 [received]
PHST- 2016/02/10 00:00 [accepted]
PHST- 2016/03/25 06:00 [entrez]
PHST- 2016/03/25 06:00 [pubmed]
PHST- 2017/08/18 06:00 [medline]
AID - /j/cclm.ahead-of-print/cclm-2015-1110/cclm-2015-1110.xml [pii]
AID - 10.1515/cclm-2015-1110 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 2016 Aug 1;54(8):1319-27. doi: 10.1515/cclm-2015-1110.