PMID- 27011946
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160325
LR  - 20201001
IS  - 2250-1541 (Print)
IS  - 1947-2714 (Electronic)
IS  - 1947-2714 (Linking)
VI  - 8
IP  - 1
DP  - 2016 Jan
TI  - The Pathogenesis of Rheumatoid Arthritis is Associated with Milk or Egg Allergy.
PG  - 40-6
LID - 10.4103/1947-2714.175206 [doi]
AB  - BACKGROUND: Rheumatoid arthritis (RA) is a very complicated autoimmune disease 
      with apparent synovial hyperplasia and cartilage and bone destruction. AIMS: In 
      the present study, we aimed to determine whether the pathogenesis of RA 
      correlates with food allergy and which allergen(s) are relevant. MATERIALS AND 
      METHODS: We used type-II collagen (CII) to induce arthritis (collagen-induced 
      arthritis, CIA) model in Wistar rats, and the development of arthritis was 
      evaluated accordingly by scoring system. Proinflammatory cytokine levels in 
      plasma were measured by enzyme-linked immunosorbent assay (ELISA), and 
      concentrations of circulating immune complexes (CICs) were analyzed by C1q solid 
      phase method. Furthermore, food-specific immunoglobulin G (IgG) and 
      immunoglobulin E (IgE) levels were determined in the CIA model. RESULTS: In the 
      CIA model, we found that levels of tumor necrosis factor-alpha (TNF-a), 
      interleukin (IL)-1, IL-6, and IL-17, as well as CICs, were elevated 
      significantly. Moreover, concentrations of milk- or egg-specific IgG and IgE were 
      enhanced strikingly in CIA rats. CONCLUSION: The results suggest that 
      pathogenesis of RA correlates closely to increased egg- or milk-specific 
      antibodies.
FAU - Li, Jianjie
AU  - Li J
AD  - Institue of Allergy and Immunology, School of Medicine, Shen Zhen University, 
      Shenzhen, China.
FAU - Yan, Hao
AU  - Yan H
AD  - Institue of Allergy and Immunology, School of Medicine, Shen Zhen University, 
      Shenzhen, China.
FAU - Chen, He
AU  - Chen H
AD  - Institue of Allergy and Immunology, School of Medicine, Shen Zhen University, 
      Shenzhen, China.
FAU - Ji, Qiongmei
AU  - Ji Q
AD  - Institue of Allergy and Immunology, School of Medicine, Shen Zhen University, 
      Shenzhen, China.
FAU - Huang, Shengguang
AU  - Huang S
AD  - Department of Rheumatism, Traditional Chinese Medicine, The Sixth People's 
      Hospital of Shenzhen City, Shenzhen, China.
FAU - Yang, Pingchang
AU  - Yang P
AD  - Institue of Allergy and Immunology, School of Medicine, Shen Zhen University, 
      Shenzhen, China.
FAU - Liu, Zhigang
AU  - Liu Z
AD  - Institue of Allergy and Immunology, School of Medicine, Shen Zhen University, 
      Shenzhen, China.
FAU - Yang, Bo
AU  - Yang B
AD  - Institue of Allergy and Immunology, School of Medicine, Shen Zhen University, 
      Shenzhen, China; Key Laboratory of Optoelectronic Devices and Systems of Ministry 
      of Education and Guangdong Province, College of Optoelectronic Engineering, 
      Shenzhen University, Shenzhen, China.
LA  - eng
PT  - Journal Article
PL  - India
TA  - N Am J Med Sci
JT  - North American journal of medical sciences
JID - 101521411
PMC - PMC4784182
OTO - NOTNLM
OT  - Egg allergen
OT  - food allergy
OT  - milk allergen
OT  - proinflammatory cytokines
OT  - rheumatoid arthritis (RA)
EDAT- 2016/03/25 06:00
MHDA- 2016/03/25 06:01
PMCR- 2016/01/01
CRDT- 2016/03/25 06:00
PHST- 2016/03/25 06:00 [entrez]
PHST- 2016/03/25 06:00 [pubmed]
PHST- 2016/03/25 06:01 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - NAJMS-8-40 [pii]
AID - 10.4103/1947-2714.175206 [doi]
PST - ppublish
SO  - N Am J Med Sci. 2016 Jan;8(1):40-6. doi: 10.4103/1947-2714.175206.