PMID- 27013183
OWN - NLM
STAT- MEDLINE
DCOM- 20171120
LR  - 20221207
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 6
IP  - 8
DP  - 2016 Aug
TI  - HLA-DRB1*08:03:02 and HLA-DQB1*06:01:01 are associated with house dust 
      mite-sensitive allergic rhinitis in Chinese subjects.
PG  - 854-61
LID - 10.1002/alr.21747 [doi]
AB  - BACKGROUND: Allergic rhinitis (AR) is a multifactorial immunologic disease that 
      is influenced by both genetic and environment factors. House dust mites (HDMs) 
      are important inhalant aeroallergens and are an epidemiologic risk factor for AR. 
      Similarly, the human leukocyte antigen (HLA) class II genes DQB1 and DRB1 have 
      been shown to be associated with AR and play an important role in the regulation 
      of the immune response. The objective of this work was to elucidate the HLA-II 
      gene alleles associated with AR in HDM-sensitive Han Chinese subjects. METHODS: A 
      total of 142 patients with AR and 184 healthy subjects were recruited to this 
      case-control study. Diagnosis of AR was based on medical history, laryngological 
      examination, skin-prick tests, and HMD-specific immunoglobulin E (IgE) assays. 
      Genotyping of HLA-DRB1 and HAL-DQB1 was performed by the polymerase chain 
      reaction sequence-based genotyping method. RESULTS: A total of 35 alleles of the 
      HLA-DRB1 locus and 19 alleles of the HLA-DQB1 locus were genotyped in the entire 
      study cohort; the frequencies of alleles DQB1*06:01:01 (corrected p value [pc ] = 
      0.009; odds ratio [OR] = 2.684; 95% confidence interval [CI] = 1.482 to 4.994) 
      and DRB1*08:03:02 (pc = 0.009; OR = 3.754; 95% CI = 1.724 to 8.851) were 
      significantly increased in HDM-sensitive AR patients compared to healthy controls 
      and are considered to be a risk factor for AR in Chinese Han subjects. The 
      frequency of haplotype DRB1*08:03-DQB1*06:01 in the HDM-sensitive AR group was 
      also significantly higher than in the control group (9.5% vs 2.4%; pc = 0.005; OR 
      = 4.182; 95% CI = 1.870 to 10.285). Serological antigen types assessment further 
      demonstrated the frequency of HLA-DRB1*08 (pc = 0.022; OR = 2.982; 95% CI = 1.46 
      to 6.400) to be significantly increased in HDM-sensitive AR patients, and the 
      frequencies of DRB1*14 (pc = 0.030; OR = 0.340; 95% CI = 0.154 to 0.694) and 
      DQB1*05 (pc = 0.030; OR = 0.459; 95% CI = 0.269 to 0.764) to be significantly 
      decreased, compared to healthy controls, suggesting that HLA-DRB1*08 might be a 
      risk factor, and DRB1*14 and DQB1*05 protective factors for HDM-sensitive AR. 
      CONCLUSION: HLA-DRB1*08:03:02 and HLA-DQB1*06:01:01 are associated with 
      HMD-sensitive AR and may confer a risk for development of AR in Han Chinese 
      subjects sensitized to HDM.
CI  - (c) 2016 ARS-AAOA, LLC.
FAU - Zhao, Yanming
AU  - Zhao Y
AD  - Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, 
      Capital Medical University, Beijing, China.
FAU - Zhao, Yali
AU  - Zhao Y
AD  - Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, 
      Beijing, China.
FAU - Li, Jingyun
AU  - Li J
AD  - Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, 
      Beijing, China.
FAU - Zhang, Yuan
AU  - Zhang Y
AD  - Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, 
      Capital Medical University, Beijing, China.
AD  - Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, 
      Beijing, China.
AD  - Department of Allergy, Beijing TongRen Hospital, Capital Medical University, 
      Beijing, China.
FAU - Zhang, Luo
AU  - Zhang L
AD  - Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, 
      Capital Medical University, Beijing, China.
AD  - Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, 
      Beijing, China.
AD  - Department of Allergy, Beijing TongRen Hospital, Capital Medical University, 
      Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20160325
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 0 (Allergens)
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Arthropod Proteins)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Allergens/immunology
MH  - Animals
MH  - Antigens, Dermatophagoides/immunology
MH  - Arthropod Proteins/immunology
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Child
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Immunoglobulin E/blood/immunology
MH  - Male
MH  - Pyroglyphidae/immunology
MH  - Rhinitis, Allergic/blood/diagnosis/*genetics/immunology
MH  - Skin Tests
MH  - Young Adult
OTO - NOTNLM
OT  - Allergic rhinitis
OT  - DQB1
OT  - DRB1
OT  - House dust mites (HDMs)
OT  - Human leukocyte antigen (HLA)
EDAT- 2016/03/26 06:00
MHDA- 2017/11/29 06:00
CRDT- 2016/03/26 06:00
PHST- 2015/09/25 00:00 [received]
PHST- 2016/01/06 00:00 [revised]
PHST- 2016/01/22 00:00 [accepted]
PHST- 2016/03/26 06:00 [entrez]
PHST- 2016/03/26 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
AID - 10.1002/alr.21747 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2016 Aug;6(8):854-61. doi: 10.1002/alr.21747. Epub 2016 
      Mar 25.