PMID- 27014354
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160325
LR  - 20201001
IS  - 1738-5520 (Print)
IS  - 1738-5555 (Electronic)
IS  - 1738-5520 (Linking)
VI  - 46
IP  - 2
DP  - 2016 Mar
TI  - White Blood Cell Count to Mean Platelet Volume Ratio Is a Prognostic Factor in 
      Patients with Non-ST Elevation Acute Coronary Syndrome with or without Metabolic 
      Syndrome.
PG  - 229-38
LID - 10.4070/kcj.2016.46.2.229 [doi]
AB  - BACKGROUND AND OBJECTIVES: Leukocyte and platelet have been found to be 
      associated with metabolic syndrome (MetS). We aimed to determine the usefulness 
      of a novel marker named white blood cell count to mean platelet volume ratio 
      (WMR) for predicting outcomes of non-ST elevation acute coronary syndrome 
      (NSTE-ACS) with or without MetS. SUBJECTS AND METHODS: A total of 331 NSTE-ACS 
      individuals (60+/-12.5 years, 57.4% male) were enrolled and followed for a median 
      of 24 months. MetS was identified using the National Cholesterol Education 
      Program Adult Treatment Panel III criteria. RESULTS: Patients were divided into 
      two groups: high WMR (WMR>/=720) and low WMR (WMR<720). Major adverse 
      cardiovascular events (MACE) and MetS rates were significantly greater in the 
      higher WMR group compared to those in the low WMR group (MACE: 14.3% vs. 25%, 
      p=0.014; MetS: 50.9% vs. 75%, p<0.001). MetS was diagnosed in 62.2% of patients. 
      MACE incidence in patients with or without MetS was comparable (p=0.737). Among 
      MetS individuals, patients in the high WMR group had more MACE than the low WMR 
      group (11.2% vs. 26.5%, p=0.007). However, MACE was comparable among non-MetS 
      individuals (p=0.681). In multivariable Cox regression analysis, hazard ratios 
      (HR) of MACE incidence for high-WMR in MetS individuals was 2.616 (95% confidence 
      interval: 1.282-5.339, p=0.008). However, HR of MACE incidence for high WMR in 
      non-MetS individuals was not significant. CONCLUSION: Among NSTE-ACS patients 
      without revascularization therapy, elevated admission WMR was associated with an 
      increased risk of developing composite MACE in MetS individuals but not in 
      non-MetS patients.
FAU - Dehghani, Mohammad Reza
AU  - Dehghani MR
AD  - Department of Cardiology, Urmia University of Medical Sciences, Urmia, Iran.
FAU - Rezaei, Yousef
AU  - Rezaei Y
AD  - Seyyed-al-Shohada Heart Center, Urmia University of Medical Sciences, Urmia, 
      Iran.
FAU - Fakour, Sanam
AU  - Fakour S
AD  - School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
FAU - Arjmand, Nasim
AU  - Arjmand N
AD  - School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
LA  - eng
PT  - Journal Article
DEP - 20160321
PL  - Korea (South)
TA  - Korean Circ J
JT  - Korean circulation journal
JID - 101247141
PMC - PMC4805568
OTO - NOTNLM
OT  - Acute coronary syndrome
OT  - Inflammation
OT  - Mean platelet volume
OT  - Metabolic syndrome
OT  - White blood cell count
COIS- The authors have no financial conflicts of interest.
EDAT- 2016/03/26 06:00
MHDA- 2016/03/26 06:01
PMCR- 2016/03/01
CRDT- 2016/03/26 06:00
PHST- 2015/06/02 00:00 [received]
PHST- 2015/07/14 00:00 [revised]
PHST- 2015/08/11 00:00 [accepted]
PHST- 2016/03/26 06:00 [entrez]
PHST- 2016/03/26 06:00 [pubmed]
PHST- 2016/03/26 06:01 [medline]
PHST- 2016/03/01 00:00 [pmc-release]
AID - 10.4070/kcj.2016.46.2.229 [doi]
PST - ppublish
SO  - Korean Circ J. 2016 Mar;46(2):229-38. doi: 10.4070/kcj.2016.46.2.229. Epub 2016 
      Mar 21.