PMID- 27014760
OWN - NLM
STAT- MEDLINE
DCOM- 20170123
LR  - 20181023
IS  - 1842-1121 (Electronic)
IS  - 1841-8724 (Linking)
VI  - 25
IP  - 1
DP  - 2016 Mar
TI  - Recovery from LCDD-associated Severe Liver Cholestasis: a Case Report and 
      Literature Review.
PG  - 99-103
LID - 10.15403/jgld.2014.1121.251.lcd [doi]
AB  - Light chain deposition disease (LCDD) is a rare multisystemic disorder associated 
      with plasma cell proliferation. It mainly affects the kidney, but liver and heart 
      involvement may occur, sometimes mimicking the picture of systemic amyloidosis. 
      Liver disease in LCDD is usually asymptomatic and exceptionally manifests with 
      severe cholestatic hepatitis. We report the case of a 66-year-old female with 
      kappa-LCDD and cast nephropathy in the setting of symptomatic multiple myeloma who, 
      after a first cycle of bortezomib-dexamethasone chemotherapy, developed severe 
      and rapidly worsening intrahepatic cholestasis secondary to liver kappa-light chain 
      deposition. Intrahepatic cholestasis was attributed to LCDD on the basis of the 
      liver histology and exclusion of possible diagnoses. Chemotherapy was maintained 
      and resulted in progressive resolution of cholestasis. We report here an uncommon 
      presentation of LCDD, with prominent liver involvement that fully recovered with 
      bortezomib-based chemotherapy, and briefly review the relevant literature.
FAU - Brilland, Benoit
AU  - Brilland B
AD  - LUNAM Universite, Angers;CHU Angers, Service de 
      Nephrologie-Dialyse-Transplantation, Poitiers, France.
FAU - Sayegh, Johnny
AU  - Sayegh J
AD  - LUNAM Universite, Angers;CHU Angers, Service de 
      Nephrologie-Dialyse-Transplantation, Poitiers, France.
FAU - Croue, Anne
AU  - Croue A
AD  - LUNAM Universite, Angers;CHU Angers, Departement de Pathologie Cellulaire et 
      Tissulaire, Angers, France.
FAU - Bridoux, Frank
AU  - Bridoux F
AD  - Departement de Nephrologie et Transplantation, CHU Poitiers, Poitiers, France.
FAU - Subra, Jean-Francois
AU  - Subra JF
AD  - LUNAM Universite, Angers;CHU Angers, Service de 
      Nephrologie-Dialyse-Transplantation, Poitiers, France.
FAU - Augusto, Jean-Francois
AU  - Augusto JF
AD  - LUNAM Universite, Angers;CHU Angers, Service de 
      Nephrologie-Dialyse-Transplantation, Poitiers, France. jfaugusto@chu-angers.fr.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - Romania
TA  - J Gastrointestin Liver Dis
JT  - Journal of gastrointestinal and liver diseases : JGLD
JID - 101272825
RN  - 0 (Immunoglobulin kappa-Chains)
RN  - 69G8BD63PP (Bortezomib)
RN  - 7S5I7G3JQL (Dexamethasone)
SB  - IM
MH  - Aged
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Biopsy
MH  - Bortezomib/administration & dosage
MH  - Cholestasis, Intrahepatic/diagnosis/*etiology/*immunology
MH  - Dexamethasone/administration & dosage
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - Immunoglobulin kappa-Chains/*immunology
MH  - Liver/*immunology/pathology
MH  - Multiple Myeloma/*complications/diagnosis/drug therapy/immunology
MH  - Treatment Outcome
EDAT- 2016/03/26 06:00
MHDA- 2017/01/24 06:00
CRDT- 2016/03/26 06:00
PHST- 2016/03/26 06:00 [entrez]
PHST- 2016/03/26 06:00 [pubmed]
PHST- 2017/01/24 06:00 [medline]
AID - 15 [pii]
AID - 10.15403/jgld.2014.1121.251.lcd [doi]
PST - ppublish
SO  - J Gastrointestin Liver Dis. 2016 Mar;25(1):99-103. doi: 
      10.15403/jgld.2014.1121.251.lcd.