PMID- 27016609
OWN - NLM
STAT- MEDLINE
DCOM- 20170728
LR  - 20171109
IS  - 1550-6606 (Electronic)
IS  - 0022-1767 (Linking)
VI  - 196
IP  - 9
DP  - 2016 May 1
TI  - TIGIT Enhances Antigen-Specific Th2 Recall Responses and Allergic Disease.
PG  - 3570-80
LID - 10.4049/jimmunol.1501591 [doi]
AB  - T cell Ig and ITIM domain receptor (TIGIT), expressed on T, NK, and regulatory T 
      cells, is known as an inhibitory molecule that limits autoimmunity, antiviral and 
      antitumor immunity. In this report, we demonstrate that TIGIT enhances Th2 
      immunity. TIGIT expression was upregulated in activated Th2 cells from mice with 
      experimental allergic disease and in Th2 polarization cultures. In addition, its 
      high-affinity ligand CD155 was upregulated in mediastinal lymph node dendritic 
      cells from allergic mice. In an in vitro setting, we observed that Tigit 
      expression in Th2 cells and its interaction with CD155 expressed in dendritic 
      cells were important during the development of Th2 responses. In addition, 
      blockade of TIGIT inhibited Th2, but had no effect on either Th1 or Th17 
      polarization. In vivo blockade of TIGIT suppressed hallmarks of allergic airway 
      disease, such as lung eosinophilia, goblet cell hyperplasia, Ag-specific Th2 
      responses, and IgE production, and reduced numbers of T follicular helper and 
      effector Th2 cells. Thus, TIGIT is critical for Th2 immunity and can be used as a 
      therapeutic target, especially in light of recent findings showing TIGIT locus 
      hypomethylation in T cells from pediatric patients with allergic asthma.
CI  - Copyright (c) 2016 by The American Association of Immunologists, Inc.
FAU - Kourepini, Evangelia
AU  - Kourepini E
AUID- ORCID: 0000-0002-2299-1007
AD  - Cellular Immunology Laboratory, Center for Basic Research, Biomedical Research 
      Foundation of the Academy of Athens, Athens 115 27, Greece; and.
FAU - Paschalidis, Nikolaos
AU  - Paschalidis N
AD  - Cellular Immunology Laboratory, Center for Basic Research, Biomedical Research 
      Foundation of the Academy of Athens, Athens 115 27, Greece; and.
FAU - Simoes, Davina C M
AU  - Simoes DC
AD  - Cellular Immunology Laboratory, Center for Basic Research, Biomedical Research 
      Foundation of the Academy of Athens, Athens 115 27, Greece; and.
FAU - Aggelakopoulou, Maria
AU  - Aggelakopoulou M
AD  - Cellular Immunology Laboratory, Center for Basic Research, Biomedical Research 
      Foundation of the Academy of Athens, Athens 115 27, Greece; and.
FAU - Grogan, Jane L
AU  - Grogan JL
AD  - Department of Cancer Immunology, Genentech, South San Francisco, CA 94080.
FAU - Panoutsakopoulou, Vily
AU  - Panoutsakopoulou V
AUID- ORCID: 0000-0002-1569-1508
AD  - Cellular Immunology Laboratory, Center for Basic Research, Biomedical Research 
      Foundation of the Academy of Athens, Athens 115 27, Greece; and 
      vpan@bioacademy.gr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160325
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Cytokines)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Virus)
RN  - 0 (T cell Ig and ITIM domain protein, mouse)
RN  - 0 (poliovirus receptor)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Cytokines/immunology
MH  - Dendritic Cells/immunology
MH  - Female
MH  - Goblet Cells/immunology
MH  - Hyperplasia/immunology
MH  - Hypersensitivity/*immunology
MH  - Immunoglobulin E/biosynthesis/immunology
MH  - *Immunologic Memory
MH  - Lymphocyte Activation
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Pulmonary Eosinophilia/immunology
MH  - Receptors, Immunologic/genetics/*metabolism
MH  - Receptors, Virus/genetics
MH  - Th17 Cells/immunology
MH  - Th2 Cells/*immunology/physiology
EDAT- 2016/03/27 06:00
MHDA- 2017/07/29 06:00
CRDT- 2016/03/27 06:00
PHST- 2015/07/17 00:00 [received]
PHST- 2016/02/23 00:00 [accepted]
PHST- 2016/03/27 06:00 [entrez]
PHST- 2016/03/27 06:00 [pubmed]
PHST- 2017/07/29 06:00 [medline]
AID - jimmunol.1501591 [pii]
AID - 10.4049/jimmunol.1501591 [doi]
PST - ppublish
SO  - J Immunol. 2016 May 1;196(9):3570-80. doi: 10.4049/jimmunol.1501591. Epub 2016 
      Mar 25.