PMID- 27017391
OWN - NLM
STAT- MEDLINE
DCOM- 20170808
LR  - 20220331
IS  - 2005-6648 (Electronic)
IS  - 1226-3303 (Print)
IS  - 1226-3303 (Linking)
VI  - 31
IP  - 5
DP  - 2016 Sep
TI  - Periodontitis is associated with rheumatoid arthritis: a study with longstanding 
      rheumatoid arthritis patients in Korea.
PG  - 977-86
LID - 10.3904/kjim.2015.202 [doi]
AB  - BACKGROUND/AIMS: A cross-sectional study was undertaken to investigate the 
      association between severity of periodontitis and clinical manifestation of 
      rheumatoid arthritis (RA). METHODS: Two hundred sixty-four RA patients and 88 
      age- and sex-matched controls underwent dental exam. Additionally, clinical 
      manifestations including disease activity and anti-citrullinated protein 
      antibodies were evaluated in RA patients. RESULTS: The prevalence of moderate or 
      severe periodontitis was higher in RA patients compared to controls (63.6% vs 
      34.1%, p < 0.001). In markers of periodontal inflammation, bleeding on probing 
      was correlated with disease activity score 28 (r = 0.128, p = 0.041), RA disease 
      duration (r = 0.211, p = 0.001), erythrocyte sedimentation rate (ESR; r = 0.141, 
      p = 0.023), anti-cyclic citrullinated peptide antibody (r = 0.183, p = 0.009), 
      and anti-citrullinated alpha-enolase peptide-1 antibody (r = 0.143, p = 0.025). 
      Gingival index was correlated with RA duration (r = 0.262, p < 0.001), ESR (r = 
      0.162, p = 0.009), anti-cyclic citrullinated peptide antibody (r = 0.203, p = 
      0.004) and anti-citrullinated alpha-enolase peptide-1 antibody (r = 0.225, p < 
      0.001). Periodontal structural damage represented by probing pocket depth and 
      clinical attachment level were less in RA patients with human leukocyte antigen 
      (HLA)-DRB1 shared epitope compared than those without shared epitope (p = 0.005 
      and p =0.006, respectively). CONCLUSIONS: The prevalence of moderate or severe 
      periodontitis was increased in RA patients compared to controls. Periodontal 
      inflammation was correlated with RA disease duration, ESR, and anti-citrullinated 
      protein antibodies. Periodontal structural damage was less in RA patients with 
      HLA-DRB1 shared epitope.
FAU - Choi, In Ah
AU  - Choi IA
AD  - Department of Internal Medicine, Medical Research Center, Seoul National 
      University College of Medicine, Seoul, Korea.
FAU - Kim, Jin-Hee
AU  - Kim JH
AD  - Department of Periodontology, Seoul National University School of Dentistry, 
      Seoul, Korea.
FAU - Kim, Yong Mi
AU  - Kim YM
AD  - Department of Periodontology, Seoul National University School of Dentistry, 
      Seoul, Korea.
FAU - Lee, Joo Youn
AU  - Lee JY
AD  - Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National 
      University, Seoul, Korea.
FAU - Kim, Kyung Hwa
AU  - Kim KH
AD  - Department of Periodontology, Seoul National University School of Dentistry, 
      Seoul, Korea.
AD  - Dental Research Institute, Seoul National University School of Dentistry, Seoul, 
      Korea.
FAU - Lee, Eun Young
AU  - Lee EY
AD  - Department of Internal Medicine, Medical Research Center, Seoul National 
      University College of Medicine, Seoul, Korea.
FAU - Lee, Eun Bong
AU  - Lee EB
AD  - Department of Internal Medicine, Medical Research Center, Seoul National 
      University College of Medicine, Seoul, Korea.
FAU - Lee, Yong-Moo
AU  - Lee YM
AD  - Department of Periodontology, Seoul National University School of Dentistry, 
      Seoul, Korea.
AD  - Dental Research Institute, Seoul National University School of Dentistry, Seoul, 
      Korea.
FAU - Song, Yeong Wook
AU  - Song YW
AD  - Department of Internal Medicine, Medical Research Center, Seoul National 
      University College of Medicine, Seoul, Korea.
AD  - Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National 
      University, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20160325
PL  - Korea (South)
TA  - Korean J Intern Med
JT  - The Korean journal of internal medicine
JID - 8712418
RN  - 0 (Autoantibodies)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Peptides, Cyclic)
RN  - 0 (cyclic citrullinated peptide)
SB  - IM
MH  - Aged
MH  - Arthritis, Rheumatoid/*complications/immunology
MH  - Autoantibodies/blood
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - HLA-DRB1 Chains/blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Peptides, Cyclic/immunology
MH  - Periodontitis/*complications/epidemiology/immunology
MH  - Prevalence
MH  - Prospective Studies
MH  - Republic of Korea/epidemiology
PMC - PMC5016284
OTO - NOTNLM
OT  - Arthritis, rheumatoid
OT  - Periodontitis
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2016/03/28 06:00
MHDA- 2017/08/09 06:00
PMCR- 2016/09/01
CRDT- 2016/03/28 06:00
PHST- 2015/07/03 00:00 [received]
PHST- 2015/08/28 00:00 [revised]
PHST- 2015/09/02 00:00 [accepted]
PHST- 2016/03/28 06:00 [entrez]
PHST- 2016/03/28 06:00 [pubmed]
PHST- 2017/08/09 06:00 [medline]
PHST- 2016/09/01 00:00 [pmc-release]
AID - kjim.2015.202 [pii]
AID - kjim-2015-202 [pii]
AID - 10.3904/kjim.2015.202 [doi]
PST - ppublish
SO  - Korean J Intern Med. 2016 Sep;31(5):977-86. doi: 10.3904/kjim.2015.202. Epub 2016 
      Mar 25.