PMID- 27017888
OWN - NLM
STAT- MEDLINE
DCOM- 20171128
LR  - 20240326
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Print)
IS  - 1600-6135 (Linking)
VI  - 16
IP  - 9
DP  - 2016 Sep
TI  - Validation of the BETA-2 Score: An Improved Tool to Estimate Beta Cell Function 
      After Clinical Islet Transplantation Using a Single Fasting Blood Sample.
PG  - 2704-13
LID - 10.1111/ajt.13807 [doi]
AB  - The beta score, a composite measure of beta cell function after islet 
      transplantation, has limited sensitivity because of its categorical nature and 
      requires a mixed-meal tolerance test (MMTT). We developed a novel score based on 
      a single fasting blood sample. The BETA-2 score used stepwise forward linear 
      regression incorporating glucose (in millimoles per liter), C-peptide (in 
      nanomoles per liter), hemoglobin A1c (as a percentage) and insulin dose (U/kg per 
      day) as continuous variables from the original beta score data set (n = 183 
      MMTTs). Primary and secondary analyses assessed the score's ability to detect 
      glucose intolerance (90-min MMTT glucose >/=8 mmol/L) and insulin independence, 
      respectively. A validation cohort of islet transplant recipients (n = 114 MMTTs) 
      examined 12 mo after transplantation was used to compare the score's ability to 
      detect these outcomes. The BETA-2 score was expressed as follows (range 0-42): 
      [Formula: see text] A score <20 and >/=15 detected glucose intolerance and insulin 
      independence, respectively, with >82% sensitivity and specificity. The BETA-2 
      score demonstrated greater discrimination than the beta score for these outcomes 
      (p < 0.05). Using a fasting blood sample, the BETA-2 score estimates graft 
      function as a continuous variable and shows greater discrimination of glucose 
      intolerance and insulin independence after transplantation versus the beta score, 
      allowing frequent assessments of graft function. Studies examining its utility to 
      track long-term graft function are required.
CI  - (c) 2016 The Authors. American Journal of Transplantation published by Wiley 
      Periodicals, Inc. on behalf of the American Society of Transplantation and the 
      American Society of Transplant Surgeons.
FAU - Forbes, S
AU  - Forbes S
AD  - Department of Medicine, Clinical Islet Transplant Program, University of Alberta 
      & Alberta Health Services, Edmonton, Alberta, Canada.
AD  - BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
FAU - Oram, R A
AU  - Oram RA
AD  - Department of Medicine, Clinical Islet Transplant Program, University of Alberta 
      & Alberta Health Services, Edmonton, Alberta, Canada.
FAU - Smith, A
AU  - Smith A
AD  - Department of Medicine, Clinical Islet Transplant Program, University of Alberta 
      & Alberta Health Services, Edmonton, Alberta, Canada.
AD  - Department of Surgery, Clinical Islet Transplant Program, University of Alberta & 
      Alberta Health Services, Edmonton, Alberta, Canada.
FAU - Lam, A
AU  - Lam A
AD  - Department of Medicine, Clinical Islet Transplant Program, University of Alberta 
      & Alberta Health Services, Edmonton, Alberta, Canada.
FAU - Olateju, T
AU  - Olateju T
AD  - Department of Medicine, Clinical Islet Transplant Program, University of Alberta 
      & Alberta Health Services, Edmonton, Alberta, Canada.
FAU - Imes, S
AU  - Imes S
AD  - Department of Medicine, Clinical Islet Transplant Program, University of Alberta 
      & Alberta Health Services, Edmonton, Alberta, Canada.
AD  - Department of Surgery, Clinical Islet Transplant Program, University of Alberta & 
      Alberta Health Services, Edmonton, Alberta, Canada.
FAU - Malcolm, A J
AU  - Malcolm AJ
AD  - Department of Medicine, Clinical Islet Transplant Program, University of Alberta 
      & Alberta Health Services, Edmonton, Alberta, Canada.
AD  - Department of Surgery, Clinical Islet Transplant Program, University of Alberta & 
      Alberta Health Services, Edmonton, Alberta, Canada.
FAU - Shapiro, A M J
AU  - Shapiro AM
AD  - Department of Surgery, Clinical Islet Transplant Program, University of Alberta & 
      Alberta Health Services, Edmonton, Alberta, Canada.
FAU - Senior, P A
AU  - Senior PA
AD  - Department of Medicine, Clinical Islet Transplant Program, University of Alberta 
      & Alberta Health Services, Edmonton, Alberta, Canada.
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20160421
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (C-Peptide)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Biomarkers/*blood
MH  - Blood Glucose/analysis
MH  - C-Peptide/blood
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 1/*surgery
MH  - Fasting/*physiology
MH  - Female
MH  - Follow-Up Studies
MH  - Glucose Tolerance Test
MH  - Glycated Hemoglobin/analysis
MH  - Graft Survival
MH  - Humans
MH  - Islets of Langerhans/*physiology
MH  - *Islets of Langerhans Transplantation
MH  - Male
MH  - Prognosis
MH  - Severity of Illness Index
PMC - PMC5074289
OTO - NOTNLM
OT  - clinical research/practice
OT  - diabetes: type 1
OT  - endocrinology/diabetology
OT  - immunosuppressant
OT  - immunosuppressive regimens
OT  - islet transplantation
OT  - islets of Langerhans
OT  - translational research/science
EDAT- 2016/03/29 06:00
MHDA- 2017/11/29 06:00
PMCR- 2016/10/21
CRDT- 2016/03/29 06:00
PHST- 2016/01/21 00:00 [received]
PHST- 2016/03/01 00:00 [revised]
PHST- 2016/03/19 00:00 [accepted]
PHST- 2016/03/29 06:00 [entrez]
PHST- 2016/03/29 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2016/10/21 00:00 [pmc-release]
AID - S1600-6135(22)00811-5 [pii]
AID - AJT13807 [pii]
AID - 10.1111/ajt.13807 [doi]
PST - ppublish
SO  - Am J Transplant. 2016 Sep;16(9):2704-13. doi: 10.1111/ajt.13807. Epub 2016 Apr 
      21.