PMID- 27019428
OWN - NLM
STAT- MEDLINE
DCOM- 20161230
LR  - 20190923
IS  - 0973-7731 (Electronic)
IS  - 0022-1333 (Linking)
VI  - 95
IP  - 1
DP  - 2016 Mar
TI  - KIR : HLA association with clinical manifestations of HBV infection in Madurai, 
      south India.
PG  - 13-9
AB  - The antiviral action of natural killer (NK) cells is regulated by a wide 
      repertoire of germ-line encoded membrane receptors which recognize the expression 
      of certain self-molecules on target cells. Among the receptors, killer cell 
      immunoglobulinlike receptor (KIR) which recognizes the expression of human 
      leukocyte antigen (HLA) class I has a predominant role in regulating the effector 
      functions of NK cells, particularly in viral infections.We studied a total of 128 
      hepatitis B virus (HBV) patients (15 acute, 43 asymptomatic, 27 chronic and 43 
      with other liver diseases) while attending the Department of Medical 
      Gastroenterology, Government Rajaji Hospital, Madurai, India, and 128 ethnic 
      matched control to find the association between the KIR : HLA genes and 
      differential manifestations of HBV. KIR and its ligand HLA polymorphism were 
      identified by DNAPCR methods. The activatory receptor KIR-2DS1 was significantly 
      elevated in various disease categories, namely asymptomatic, chronic and other 
      HBV, except acute HBV infection. Whereas, KIR 2DS3 in acute and chronic patients 
      and KIR 2DS5 and 3DS1 in asymptomatic individuals. Among various KIR-HLA 
      combinations, homozygous 2DS2:C1 and individuals with 3DSI:BW4 (OR = 3.23, CI = 
      1.55-6.7, Pc = 0.02) are associated with HBV asymptomatism, while most of the two 
      domain inhibitory receptors with their ligands showed significant risk in other 
      liver diseases. Further, KIR3DL1 : HLA Bw4Iso80 (OR = 3.89, 95% CI = 1.58-9.55, 
      Pc = 0.004) is related with higher risk for asymptomatic infection when compared 
      with chronic HBV. Thus, the select KIR : HLA alleles and combinations seem to 
      direct the NK cell activities and immune response in different directions 
      resulting in varied symptoms and manifestations in the subgroups of HBV-infected 
      patients studied.
FAU - Kalyanaraman, Narayanan
AU  - Kalyanaraman N
AD  - Department of Immunology, School of Biological Sciences, Madurai Kamaraj 
      University, Madurai 625 021, India.jayalakshmim@genomicsmku.org.
FAU - Thayumanavan, Lakshmikanthan
AU  - Thayumanavan L
FAU - Jayalakshmi, Mariakuttikan
AU  - Jayalakshmi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - J Genet
JT  - Journal of genetics
JID - 2985113R
RN  - 0 (HLA Antigens)
RN  - 0 (Ligands)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - HLA Antigens/*immunology
MH  - Hepatitis B/*immunology/pathology
MH  - Humans
MH  - India
MH  - Ligands
MH  - Receptors, KIR/genetics/*immunology
EDAT- 2016/03/29 06:00
MHDA- 2016/12/31 06:00
CRDT- 2016/03/29 06:00
PHST- 2016/03/29 06:00 [entrez]
PHST- 2016/03/29 06:00 [pubmed]
PHST- 2016/12/31 06:00 [medline]
AID - 10.1007/s12041-015-0594-x [doi]
PST - ppublish
SO  - J Genet. 2016 Mar;95(1):13-9. doi: 10.1007/s12041-015-0594-x.