PMID- 27019761
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160329
LR  - 20201001
IS  - 2090-908X (Print)
IS  - 2090-908X (Electronic)
IS  - 2090-908X (Linking)
VI  - 2016
DP  - 2016
TI  - A High-Fat, High-Fructose Diet Induces Antioxidant Imbalance and Increases the 
      Risk and Progression of Nonalcoholic Fatty Liver Disease in Mice.
PG  - 5029414
LID - 10.1155/2016/5029414 [doi]
LID - 5029414
AB  - Excessive fat liver is an important manifestation of nonalcoholic fatty liver 
      disease (NAFLD), associated with obesity, insulin resistance, and oxidative 
      stress. In the present study, the effects of a high-fat, high-fructose diet 
      (HFFD) on mRNA levels and activities of the antioxidant enzymes, including 
      superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), 
      were determined in mouse livers and brains. The histomorphology of the livers was 
      examined and the state of nonenzymatic reducing system was evaluated by measuring 
      the glutathione system and the lipid peroxidation. Histopathology of the liver 
      showed that fat accumulation and inflammation depended on the period of the 
      HFFD-consumption. The levels of mRNA and enzymatic activities of SOD, CAT, and 
      GPx were raised, followed by the increases in malondialdehyde levels in livers 
      and brains of the HFFD mice. The oxidized GSSG content was increased while the 
      total GSH and the reduced GSH were decreased, resulting in the increase in the 
      GSH/GSSG ratio in both livers and brains of the HFFD mice. These observations 
      suggested that liver damage and oxidative stress in the significant organs were 
      generated by continuous HFFD-consumption. Imbalance of antioxidant condition 
      induced by long-term HFFD-consumption might increase the risk and progression of 
      NAFLD.
FAU - Jarukamjorn, Kanokwan
AU  - Jarukamjorn K
AUID- ORCID: 0000-0001-8774-2733
AD  - Research Group for Pharmaceutical Activities of Natural Products Using 
      Pharmaceutical Biotechnology (PANPB), Faculty of Pharmaceutical Sciences, Khon 
      Kaen University, Khon Kaen 40002, Thailand.
FAU - Jearapong, Nattharat
AU  - Jearapong N
AD  - Research Group for Pharmaceutical Activities of Natural Products Using 
      Pharmaceutical Biotechnology (PANPB), Faculty of Pharmaceutical Sciences, Khon 
      Kaen University, Khon Kaen 40002, Thailand.
FAU - Pimson, Charinya
AU  - Pimson C
AD  - Research Group for Pharmaceutical Activities of Natural Products Using 
      Pharmaceutical Biotechnology (PANPB), Faculty of Pharmaceutical Sciences, Khon 
      Kaen University, Khon Kaen 40002, Thailand.
FAU - Chatuphonprasert, Waranya
AU  - Chatuphonprasert W
AD  - Faculty of Medicine, Mahasarakham University, Mahasarakham 44000, Thailand.
LA  - eng
PT  - Journal Article
DEP - 20160225
PL  - Egypt
TA  - Scientifica (Cairo)
JT  - Scientifica
JID - 101589932
PMC - PMC4785277
EDAT- 2016/03/29 06:00
MHDA- 2016/03/29 06:01
PMCR- 2016/01/01
CRDT- 2016/03/29 06:00
PHST- 2015/12/15 00:00 [received]
PHST- 2016/02/02 00:00 [accepted]
PHST- 2016/03/29 06:00 [entrez]
PHST- 2016/03/29 06:00 [pubmed]
PHST- 2016/03/29 06:01 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 10.1155/2016/5029414 [doi]
PST - ppublish
SO  - Scientifica (Cairo). 2016;2016:5029414. doi: 10.1155/2016/5029414. Epub 2016 Feb 
      25.