PMID- 27020275
OWN - NLM
STAT- MEDLINE
DCOM- 20170306
LR  - 20181113
IS  - 1573-7330 (Electronic)
IS  - 1058-0468 (Print)
IS  - 1058-0468 (Linking)
VI  - 33
IP  - 5
DP  - 2016 May
TI  - Genetic counseling for men with recurrent pregnancy loss or recurrent 
      implantation failure due to abnormal sperm chromosomal aneuploidy.
PG  - 571-576
LID - 10.1007/s10815-016-0702-8 [doi]
AB  - PURPOSE: The purpose of this study is to review recurrent pregnancy loss (RPL) 
      due to sperm chromosomal abnormalities and discuss the genetic counseling that is 
      required for men with sperm chromosomal abnormalities. METHOD: The literature was 
      reviewed, and a genetic counselor lends her expertise as to how couples with RPL 
      and sperm chromosomal abnormalities ought to be counseled. The review of the 
      literature was performed using MEDLINE. RESULTS: Sperm fluorescence in situ 
      hybridization (FISH) can be used to determine if disomy or unbalanced chromosomal 
      translocations are present. In men with aneuploidy in sperm or who carry a 
      chromosomal translocation, pre-implantation genetic screening (PGS) combined with 
      in vitro fertilization (IVF) and intra-cytoplasmic sperm injection (ICSI) can 
      increase chances of live birth. In men with abnormal sperm FISH results, the 
      degree of increased risk of abnormal pregnancy remains unclear. Genetic 
      counselors can provide information to couples about the risk for potential 
      trisomies and sex chromosome aneuploidies and discuss their reproductive and 
      testing options such as PGS, use of donor sperm, and adoption. The provision of 
      genetic counseling also allows a couple to be educated about recommended prenatal 
      testing since pregnancies conceived with a partner who has had abnormal sperm 
      FISH are considered to be at increased risk for aneuploidy. CONCLUSION: We review 
      the literature and discuss genetic counseling for couples with RPL or recurrent 
      implantation failure due to increased sperm aneuploidy.
FAU - Kohn, Taylor P
AU  - Kohn TP
AD  - Baylor College of Medicine, Houston, TX, USA.
FAU - Kohn, Jaden R
AU  - Kohn JR
AD  - Baylor College of Medicine, Houston, TX, USA.
FAU - Darilek, Sandra
AU  - Darilek S
AD  - Molecular and Human Genetics Clinical Program, Baylor College of Medicine, 
      Houston, TX, USA.
FAU - Ramasamy, Ranjith
AU  - Ramasamy R
AD  - Department of Urology, Miller School of Medicine, University of Miami, Miami, FL, 
      USA.
FAU - Lipshultz, Larry
AU  - Lipshultz L
AD  - Scott Department of Urology, Baylor College of Medicine, 6624 Fannin Street Suite 
      1700, Houston, TX, 77030, USA. larryl@bcm.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160328
PL  - Netherlands
TA  - J Assist Reprod Genet
JT  - Journal of assisted reproduction and genetics
JID - 9206495
SB  - IM
MH  - Abortion, Habitual/*psychology
MH  - *Aneuploidy
MH  - *Genetic Counseling
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infertility, Male/*psychology
MH  - Male
MH  - Men/*psychology
MH  - Prenatal Diagnosis
MH  - Spermatozoa/*physiology
PMC - PMC4870448
OTO - NOTNLM
OT  - Chromosomal aneuploidy
OT  - Genetic counseling
OT  - Male infertility
OT  - Recurrent pregnancy loss
OT  - Sperm FISH
EDAT- 2016/03/30 06:00
MHDA- 2017/03/07 06:00
PMCR- 2017/05/01
CRDT- 2016/03/30 06:00
PHST- 2015/12/29 00:00 [received]
PHST- 2016/03/10 00:00 [accepted]
PHST- 2016/03/30 06:00 [entrez]
PHST- 2016/03/30 06:00 [pubmed]
PHST- 2017/03/07 06:00 [medline]
PHST- 2017/05/01 00:00 [pmc-release]
AID - 10.1007/s10815-016-0702-8 [pii]
AID - 702 [pii]
AID - 10.1007/s10815-016-0702-8 [doi]
PST - ppublish
SO  - J Assist Reprod Genet. 2016 May;33(5):571-576. doi: 10.1007/s10815-016-0702-8. 
      Epub 2016 Mar 28.