PMID- 27020638
OWN - NLM
STAT- MEDLINE
DCOM- 20170103
LR  - 20191113
IS  - 1499-3872 (Print)
VI  - 15
IP  - 2
DP  - 2016 Apr
TI  - Monocyte chemoattractant protein-1, transforming growth factor-beta1, nerve 
      growth factor, resistin and hyaluronic acid as serum markers: comparison between 
      recurrent acute and chronic pancreatitis.
PG  - 209-15
AB  - BACKGROUND: Diagnostic parameters that can predict the presence of chronic 
      pancreatitis (CP) in patients with recurrent pain due to pancreatitis would help 
      to direct appropriate therapy. This study aimed to compare the serum levels of 
      monocyte chemoattractant protein-1 (MCP-1), transforming growth factor-beta1 
      (TGF-beta1), nerve growth factor (NGF), resistin and hyaluronic acid (HA) in 
      patients with recurrent acute pancreatitis (RAP) and CP to assess their ability 
      to differentiate the two conditions. METHODS: Levels of serum markers assessed by 
      enzyme-linked immunosorbent assay (ELISA) were prospectively compared in 
      consecutive patients with RAP, CP and in controls, and stepwise discriminant 
      analysis was performed to identify the markers differentiating RAP from CP. 
      RESULTS: One hundred and thirteen consecutive patients (RAP=32, CP=81) and 78 
      healthy controls were prospectively enrolled. The mean (SD) age of the patients 
      was 32.0 (14.0) years; 89 (78.8%) were male. All markers were significantly 
      higher in CP patients than in the controls (P<0.001); MCP-1, NGF and HA were 
      significantly higher in RAP patients than in the controls (P<0.001). Stepwise 
      discriminant analysis showed significant difference (P=0.002) between RAP and CP 
      for resistin with an accuracy of 61.9%, discriminant scores of </=-0.479 and >/=0.189 
      indicating RAP and CP, respectively. The other markers had no differential value 
      between RAP and CP. CONCLUSION: Serum resistin is a promising marker to 
      differentiate between RAP and CP and needs validation in future studies, 
      especially in those with early CP.
FAU - Kamath, M Ganesh
AU  - Kamath MG
AD  - Department of Gastroenterology and Hepatology, Kasturba Medical College, Manipal 
      University, Manipal, India. cgpai@yahoo.co.in.
FAU - Pai, C Ganesh
AU  - Pai CG
FAU - Kamath, Asha
AU  - Kamath A
FAU - Kurien, Annamma
AU  - Kurien A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Singapore
TA  - Hepatobiliary Pancreat Dis Int
JT  - Hepatobiliary & pancreatic diseases international : HBPD INT
JID - 101151457
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (NGF protein, human)
RN  - 0 (RETN protein, human)
RN  - 0 (Resistin)
RN  - 0 (TGFB1 protein, human)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 9004-61-9 (Hyaluronic Acid)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Chemokine CCL2/*blood
MH  - Diagnosis, Differential
MH  - Discriminant Analysis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Hyaluronic Acid/*blood
MH  - Male
MH  - Middle Aged
MH  - Nerve Growth Factor/*blood
MH  - Pancreatitis/*blood/diagnosis
MH  - Pancreatitis, Chronic/*blood/diagnosis
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Recurrence
MH  - Resistin/*blood
MH  - Transforming Growth Factor beta1/*blood
MH  - Young Adult
EDAT- 2016/03/30 06:00
MHDA- 2017/01/04 06:00
CRDT- 2016/03/30 06:00
PHST- 2016/03/30 06:00 [entrez]
PHST- 2016/03/30 06:00 [pubmed]
PHST- 2017/01/04 06:00 [medline]
AID - S1499-3872(15)60029-7 [pii]
AID - 10.1016/s1499-3872(15)60029-7 [doi]
PST - ppublish
SO  - Hepatobiliary Pancreat Dis Int. 2016 Apr;15(2):209-15. doi: 
      10.1016/s1499-3872(15)60029-7.