PMID- 27021605
OWN - NLM
STAT- MEDLINE
DCOM- 20170217
LR  - 20181202
IS  - 1879-114X (Electronic)
IS  - 0149-2918 (Linking)
VI  - 38
IP  - 5
DP  - 2016 May
TI  - Association of High Homocysteine Levels With the Risk Stratification in 
      Hypertensive Patients at Risk of Stroke.
PG  - 1184-92
LID - S0149-2918(16)30143-6 [pii]
LID - 10.1016/j.clinthera.2016.03.007 [doi]
AB  - PURPOSE: We aimed to investigate the association between stroke morbidity and 
      different stratifications of classic risk factors, such as increasing age, body 
      mass index (BMI), blood lipids, and blood glucose, in hypertensive patients with 
      high homocysteine levels. METHODS: A cross-sectional study of 2258 patients with 
      primary hypertension were enrolled in this study, including 871 stroke cases 
      (62.89%) in 1385 hypertensive patients without hyperhomocysteinemia (HHcy) and 
      647 (74.11%) stroke cases in 873 hypertensive patients with HHcy. Basic 
      information of patients were collected, including age, sex, height, weight, 
      smoking, alcohol consumption, and disease history. Blood chemical assays were 
      performed to determine the levels of glucose, triglycerides, high-density 
      lipoprotein cholesterol (HDL-C), total cholesterol, and homocysteine. 
      Subsequently, comparison of stroke morbidity between the 2 groups was performed 
      after the stratification of risk factors. Moreover, the correlation between the 
      stroke morbidity and the risk factors was analyzed using a trend test in patients 
      with H-type hypertension. Univariate and multivariate logistic regression 
      analyses were used to evaluate the association between baseline factors and 
      prevalence of stroke in H-type hypertensive patients. FINDINGS: After the 
      stratification of risk factors, a statistical difference was noted in age (range, 
      45-74 yrs), glucose ranges (<6.1 and >/=7.0 mmol/L), BMI, systolic blood pressure 
      (SBP), diastolic blood pressure (DBP), non-HDL-C, and triglyceride level of <200 
      mg/dL (P<0.05) in the H-type hypertension group compared with those in non-H-type 
      hypertension group. Gradual elevation of stroke morbidity was identified with the 
      increase of fasting glucose, SBP, and DBP. In multivariate logistic regression 
      analysis, only higher SBP, DBP, fasting glucose level, homocysteine, and history 
      of diabetes mellitus were the independent predictors for the stroke morbidity. 
      IMPLICATIONS: Comprehensive evaluation and strict management of multiple risk 
      factors have become increasingly important in the alleviation of stroke morbidity 
      for H-type hypertensive patients because these patients were more sensitive to 
      the classic risk factors.
CI  - Copyright (c) 2016 Elsevier HS Journals, Inc. All rights reserved.
FAU - Pang, Hui
AU  - Pang H
AD  - Department of Cardiovascular Medicine, XuZhou Central Hospital, Xuzhou Clinical 
      School of Xuzhou Medical College, Affiliated XuZhou Hospital of Medical College 
      of Southeast University, Xuzhou, Jiangsu, China. Electronic address: 
      phui81@126.com.
FAU - Han, Bing
AU  - Han B
AD  - Department of Cardiovascular Medicine, XuZhou Central Hospital, Xuzhou Clinical 
      School of Xuzhou Medical College, Affiliated XuZhou Hospital of Medical College 
      of Southeast University, Xuzhou, Jiangsu, China.
FAU - Fu, Qiang
AU  - Fu Q
AD  - Department of Cardiovascular Medicine, XuZhou Central Hospital, Xuzhou Clinical 
      School of Xuzhou Medical College, Affiliated XuZhou Hospital of Medical College 
      of Southeast University, Xuzhou, Jiangsu, China.
FAU - Zong, Zhenkun
AU  - Zong Z
AD  - Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical College, 
      Xuzhou, Jiangsu, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160325
PL  - United States
TA  - Clin Ther
JT  - Clinical therapeutics
JID - 7706726
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Lipids)
RN  - 0 (Triglycerides)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Glucose/analysis
MH  - Blood Pressure
MH  - Cholesterol/blood
MH  - Cholesterol, HDL/blood
MH  - Cross-Sectional Studies
MH  - Female
MH  - Homocysteine/*metabolism
MH  - Humans
MH  - Hypertension/*physiopathology
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Risk Factors
MH  - Stroke/*epidemiology
MH  - Triglycerides/blood
MH  - Young Adult
OTO - NOTNLM
OT  - homocysteine
OT  - hypertension
OT  - risk factors
OT  - stratification
OT  - stroke
EDAT- 2016/03/30 06:00
MHDA- 2017/02/18 06:00
CRDT- 2016/03/30 06:00
PHST- 2015/10/06 00:00 [received]
PHST- 2016/02/27 00:00 [revised]
PHST- 2016/03/01 00:00 [accepted]
PHST- 2016/03/30 06:00 [entrez]
PHST- 2016/03/30 06:00 [pubmed]
PHST- 2017/02/18 06:00 [medline]
AID - S0149-2918(16)30143-6 [pii]
AID - 10.1016/j.clinthera.2016.03.007 [doi]
PST - ppublish
SO  - Clin Ther. 2016 May;38(5):1184-92. doi: 10.1016/j.clinthera.2016.03.007. Epub 
      2016 Mar 25.