PMID- 27022145
OWN - NLM
STAT- MEDLINE
DCOM- 20160815
LR  - 20181113
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Print)
IS  - 0022-1007 (Linking)
VI  - 213
IP  - 4
DP  - 2016 Apr 4
TI  - Arid5a regulates naive CD4+ T cell fate through selective stabilization of Stat3 
      mRNA.
PG  - 605-19
LID - 10.1084/jem.20151289 [doi]
AB  - Balance in signal transducer and activator of transcription (STAT) activation is 
      a key factor in regulating the fate of naive CD4(+)T cells. Here, we demonstrate 
      that AT-rich interactive domain-containing protein 5a (Arid5a) in T cells directs 
      naive CD4(+)T cells to differentiate into inflammatory CD4(+)T cells, especially 
      Th17 cells, through selective stabilization of Stat3(but not Stat1 and Stat5) 
      mRNA in an IL-6-dependent manner. Loss of Arid5a in T cells led to reduction of 
      STAT3 level under Th17-polarizing conditions, whereas STAT1 and STAT5 in 
      Arid5a-deficient T cells were highly activated compared with those of WT T cells 
      under the same conditions. These cells displayed the feature of antiinflammatory 
      (Il10-expressing) CD4(+)T cells. Thus, we show a T cell-intrinsic role of Arid5a 
      on fate decisions of naive CD4(+)T cells through selective stabilization of Stat3 
      mRNA.
CI  - (c) 2016 Masuda et al.
FAU - Masuda, Kazuya
AU  - Masuda K
AD  - Laboratory of Immune Regulation, World Premier International Immunology Frontier 
      Research Center, Osaka University, Osaka 565-0871, Japan 
      kazuya@ifrec.osaka-u.ac.jp kishimoto@ifrec.osaka-u.ac.jp.
FAU - Ripley, Barry
AU  - Ripley B
AD  - Laboratory of Immune Regulation, World Premier International Immunology Frontier 
      Research Center, Osaka University, Osaka 565-0871, Japan.
FAU - Nyati, Kishan Kumar
AU  - Nyati KK
AD  - Laboratory of Immune Regulation, World Premier International Immunology Frontier 
      Research Center, Osaka University, Osaka 565-0871, Japan.
FAU - Dubey, Praveen Kumar
AU  - Dubey PK
AD  - Laboratory of Immune Regulation, World Premier International Immunology Frontier 
      Research Center, Osaka University, Osaka 565-0871, Japan.
FAU - Zaman, Mohammad Mahabub-Uz
AU  - Zaman MM
AD  - Laboratory of Immune Regulation, World Premier International Immunology Frontier 
      Research Center, Osaka University, Osaka 565-0871, Japan.
FAU - Hanieh, Hamza
AU  - Hanieh H
AD  - Biological Sciences Department, College of Science, King Faisal University, 
      Al-Ahsa 31982, Saudi Arabia.
FAU - Higa, Mitsuru
AU  - Higa M
AD  - Laboratory of Immune Regulation, World Premier International Immunology Frontier 
      Research Center, Osaka University, Osaka 565-0871, Japan.
FAU - Yamashita, Kazuo
AU  - Yamashita K
AD  - Laboratory of System Immunology, World Premier International Immunology Frontier 
      Research Center, Osaka University, Osaka 565-0871, Japan.
FAU - Standley, Daron M
AU  - Standley DM
AD  - Laboratory of System Immunology, World Premier International Immunology Frontier 
      Research Center, Osaka University, Osaka 565-0871, Japan.
FAU - Mashima, Tsukasa
AU  - Mashima T
AD  - Structural Energy Bioscience Research Section, Institute of Advanced Energy, 
      Kyoto University, Kyoto 611-0011, Japan.
FAU - Katahira, Masato
AU  - Katahira M
AD  - Structural Energy Bioscience Research Section, Institute of Advanced Energy, 
      Kyoto University, Kyoto 611-0011, Japan.
FAU - Okamoto, Toru
AU  - Okamoto T
AD  - Department of Molecular Virology, Research Institute for Microbial Diseases, 
      Osaka University, Osaka 565-0871, Japan.
FAU - Matsuura, Yoshiharu
AU  - Matsuura Y
AD  - Department of Molecular Virology, Research Institute for Microbial Diseases, 
      Osaka University, Osaka 565-0871, Japan.
FAU - Takeuchi, Osamu
AU  - Takeuchi O
AD  - Laboratory of Infection and Prevention, Institute for Virus Research, Kyoto 
      University, Kyoto 606-8507, Japan.
FAU - Kishimoto, Tadamitsu
AU  - Kishimoto T
AD  - Laboratory of Immune Regulation, World Premier International Immunology Frontier 
      Research Center, Osaka University, Osaka 565-0871, Japan 
      kazuya@ifrec.osaka-u.ac.jp kishimoto@ifrec.osaka-u.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160328
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Arid5a protein, mouse)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (IL10 protein, mouse)
RN  - 0 (Interleukin-6)
RN  - 0 (RNA, Messenger)
RN  - 0 (STAT1 Transcription Factor)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (STAT5 Transcription Factor)
RN  - 0 (Stat1 protein, mouse)
RN  - 0 (Stat3 protein, mouse)
RN  - 0 (Transcription Factors)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Animals
MH  - DNA-Binding Proteins/genetics/*immunology
MH  - Interleukin-10/genetics/immunology
MH  - Interleukin-6/genetics/immunology
MH  - Mice
MH  - Mice, Knockout
MH  - RNA Stability/genetics/*immunology
MH  - RNA, Messenger/genetics/*immunology
MH  - STAT1 Transcription Factor/genetics/immunology
MH  - STAT3 Transcription Factor/genetics/*immunology
MH  - STAT5 Transcription Factor/genetics/immunology
MH  - Th17 Cells/cytology/*immunology
MH  - Transcription Factors/genetics/*immunology
PMC - PMC4821647
EDAT- 2016/03/30 06:00
MHDA- 2016/08/16 06:00
PMCR- 2016/10/04
CRDT- 2016/03/30 06:00
PHST- 2015/08/09 00:00 [received]
PHST- 2016/03/01 00:00 [accepted]
PHST- 2016/03/30 06:00 [entrez]
PHST- 2016/03/30 06:00 [pubmed]
PHST- 2016/08/16 06:00 [medline]
PHST- 2016/10/04 00:00 [pmc-release]
AID - jem.20151289 [pii]
AID - 20151289 [pii]
AID - 10.1084/jem.20151289 [doi]
PST - ppublish
SO  - J Exp Med. 2016 Apr 4;213(4):605-19. doi: 10.1084/jem.20151289. Epub 2016 Mar 28.