PMID- 27023569
OWN - NLM
STAT- MEDLINE
DCOM- 20161219
LR  - 20181202
IS  - 1660-3397 (Electronic)
IS  - 1660-3397 (Linking)
VI  - 14
IP  - 4
DP  - 2016 Mar 25
TI  - Fucoxanthin, a Marine Carotenoid, Reverses Scopolamine-Induced Cognitive 
      Impairments in Mice and Inhibits Acetylcholinesterase in Vitro.
LID - 10.3390/md14040067 [doi]
LID - 67
AB  - Fucoxanthin, a natural carotenoid abundant in edible brown seaweeds, has been 
      shown to possess anti-cancer, anti-oxidant, anti-obesity and anti-diabetic 
      effects. In this study, we report for the first time that fucoxanthin effectively 
      protects against scopolamine-induced cognitive impairments in mice. In addition, 
      fucoxanthin significantly reversed the scopolamine-induced increase of 
      acetylcholinesterase (AChE) activity and decreased both choline acetyltransferase 
      activity and brain-derived neurotrophic factor (BDNF) expression. Using an in 
      vitro AChE activity assay, we discovered that fucoxanthin directly inhibits AChE 
      with an IC50 value of 81.2 muM. Molecular docking analysis suggests that 
      fucoxanthin likely interacts with the peripheral anionic site within AChE, which 
      is in accordance with enzymatic activity results showing that fucoxanthin 
      inhibits AChE in a non-competitive manner. Based on our current findings, we 
      anticipate that fucoxanthin might exhibit great therapeutic efficacy for the 
      treatment of Alzheimer's disease by acting on multiple targets, including 
      inhibiting AChE and increasing BDNF expression.
FAU - Lin, Jiajia
AU  - Lin J
AD  - Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key 
      Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 
      315211, China. linjiajiamed@yahoo.com.
FAU - Huang, Ling
AU  - Huang L
AD  - Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key 
      Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 
      315211, China. nbhl1226@yahoo.com.
FAU - Yu, Jie
AU  - Yu J
AD  - Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key 
      Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 
      315211, China. xiao.tai.yang_jie@163.com.
FAU - Xiang, Siying
AU  - Xiang S
AD  - Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key 
      Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 
      315211, China. xiangsi.ying@163.com.
FAU - Wang, Jialing
AU  - Wang J
AD  - Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key 
      Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 
      315211, China. wjl58452@yahoo.com.
FAU - Zhang, Jinrong
AU  - Zhang J
AD  - School of Marine Sciences, Ningbo University, Ningbo 315211, China. 
      zhangjinrong@nbu.edu.cn.
FAU - Yan, Xiaojun
AU  - Yan X
AD  - School of Marine Sciences, Ningbo University, Ningbo 315211, China. 
      Yanxiaojun@nbu.edu.cn.
FAU - Cui, Wei
AU  - Cui W
AD  - Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key 
      Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 
      315211, China. cuiwei@nbu.edu.cn.
FAU - He, Shan
AU  - He S
AD  - School of Marine Sciences, Ningbo University, Ningbo 315211, China. 
      heshan@nbu.edu.cn.
FAU - Wang, Qinwen
AU  - Wang Q
AD  - Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key 
      Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 
      315211, China. wangqinwen@nbu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160325
PL  - Switzerland
TA  - Mar Drugs
JT  - Marine drugs
JID - 101213729
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cholinesterase Inhibitors)
RN  - 0 (Xanthophylls)
RN  - 06O0TC0VSM (fucoxanthin)
RN  - 36-88-4 (Carotenoids)
RN  - DL48G20X8X (Scopolamine)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
SB  - IM
MH  - Acetylcholinesterase/*metabolism
MH  - Alzheimer Disease/drug therapy
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Carotenoids/*pharmacology
MH  - Cholinesterase Inhibitors/*pharmacology
MH  - Cognitive Dysfunction/*chemically induced/*drug therapy/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Molecular Docking Simulation/methods
MH  - Scopolamine/*pharmacology
MH  - Seaweed/metabolism
MH  - Xanthophylls/*pharmacology
PMC - PMC4849071
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - acetylcholinesterase
OT  - cognitive impairments
OT  - fucoxanthin
OT  - scopolamine
EDAT- 2016/03/31 06:00
MHDA- 2016/12/20 06:00
PMCR- 2016/04/01
CRDT- 2016/03/30 06:00
PHST- 2016/01/07 00:00 [received]
PHST- 2016/03/17 00:00 [revised]
PHST- 2016/03/21 00:00 [accepted]
PHST- 2016/03/30 06:00 [entrez]
PHST- 2016/03/31 06:00 [pubmed]
PHST- 2016/12/20 06:00 [medline]
PHST- 2016/04/01 00:00 [pmc-release]
AID - md14040067 [pii]
AID - marinedrugs-14-00067 [pii]
AID - 10.3390/md14040067 [doi]
PST - epublish
SO  - Mar Drugs. 2016 Mar 25;14(4):67. doi: 10.3390/md14040067.