PMID- 27024960
OWN - NLM
STAT- MEDLINE
DCOM- 20160513
LR  - 20160330
IS  - 0033-2240 (Print)
IS  - 0033-2240 (Linking)
VI  - 72
IP  - 12
DP  - 2015
TI  - [Pharmacogenomics of severe drug hypersensitivity reactions--from bench to 
      bedside].
PG  - 779-82
AB  - Recent remarkable findings of pharmacogenomics and basic scientific research 
      provided insights in the pathogenesis of severe drug hypersensitivity reactions 
      such as drug rush with eosinophilia and systemic symptoms (DRESS), abacavir 
      hypersensitivity syndrome or blistering reactions (Stevens-Johnson syndrome, 
      toxic epidermal necrolysis). There is increasing evidence for the strong 
      associations of certain human leukocyte antigen (HLA) alleles with 
      hypersensitivity to particular drugs. HLA genes may serve as genomic biomarkers 
      of predisposition to severe adverse drug reactions and enable to prevent them. In 
      this paper we review essentials and advances in this area.
FAU - Porebski, Grzegorz
AU  - Porebski G
FAU - Dyga, Wojciech
AU  - Dyga W
FAU - Stobiecki, Marcin
AU  - Stobiecki M
FAU - Czarnobilska, Ewa
AU  - Czarnobilska E
LA  - pol
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Farmakogenomika ciezkich polekowych reakcji nadwrazliwosci--miedzy laboratorium a 
      lozkiem chorego.
PL  - Poland
TA  - Przegl Lek
JT  - Przeglad lekarski
JID - 19840720R
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Drug Hypersensitivity/*genetics
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - Humans
EDAT- 2015/01/01 00:00
MHDA- 2016/05/14 06:00
CRDT- 2016/03/31 06:00
PHST- 2016/03/31 06:00 [entrez]
PHST- 2015/01/01 00:00 [pubmed]
PHST- 2016/05/14 06:00 [medline]
PST - ppublish
SO  - Przegl Lek. 2015;72(12):779-82.