PMID- 27025198
OWN - NLM
STAT- MEDLINE
DCOM- 20181018
LR  - 20220317
IS  - 2149-2271 (Electronic)
IS  - 2149-2263 (Print)
IS  - 2149-2263 (Linking)
VI  - 16
IP  - 10
DP  - 2016 Oct
TI  - CHA2DS2-VASc-HS score in non-ST elevation acute coronary syndrome patients: 
      assessment of coronary artery disease severity and complexity and comparison to 
      other scoring systems in the prediction of in-hospital major adverse 
      cardiovascular events.
PG  - 742-748
LID - 10.14744/AnatolJCardiol.2015.6593 [doi]
AB  - OBJECTIVE: We recently described the CHA2DS2-VASc-HS score as a novel predictor 
      of coronary artery disease (CAD) severity in stable CAD patients. We aimed to 
      assess the accuracy of the CHA2DS2-VASc-HS score in the determination of CAD 
      severity and complexity and its availability in the risk stratification of 
      in-hospital major adverse cardiovascular events (MACE) in non-ST elevation acute 
      coronary syndrome (NSTE-ACS) patients. METHODS: We prospectively analyzed the 
      clinical and angiographic data of consecutive NSTE-ACS patients in our clinic. 
      Patients were classified into three tertiles according to their SYNTAX score 
      (SS): tertile 1 had an SS of 0-22; tertile 2 had an SS of 23-32; and tertile 3 
      had an SS of >32. There were no specific exclusion criteria except for previous 
      coronary artery bypass grafting (CABG) because SS was validated for only native 
      coronary arteries for this study. We used the following analyses: chi2 or Fisher's 
      exact tests, one-way analysis of variance or Kruskal-Wallis tests, Pearson's or 
      Spearman's tests, the receiver operating characteristics (ROC) curve analysis, 
      the area under the curve (AUC) or C-statistic, and pairwise comparisons of the 
      ROC curves. RESULTS: A total of 252 patients were enrolled. There were 131 
      patients in tertile 1, 79 in tertile 2, and 42 in tertile 3. The number of 
      diseased vessels was correlated with the Global Registry for Acute Coronary 
      Events (GRACE) (p<0.001), Thrombolysis in Myocardial Infarction (TIMI) (p<0.001), 
      and CHA2DS2-VASc-HS (p<0.001) scores. In the ROC curve analyses, the cut-off 
      value of the CHA2DS2-VASc-HS score in the prediction of in-hospital MACE was >5 
      with a sensitivity of 69.6% and specificity of 90.3% (AUC: 0.804, 95%: CI 
      0.750-0.851, p<0.001). We also compared the diagnostic accuracy of the 
      CHA2DS2-VASc-HS score with the TIMI and GRACE risk scores in the determination of 
      the in-hospital MACE and found no differences. CONCLUSION: The CHA2DS2-VASc-HS 
      score was positively correlated with the severity and complexity of CAD. We also 
      found that CHA2DS2-VASc-HS was comparable with other risk scores for the risk 
      stratification of the in-hospital MACE of NSTE-ACS patients. Therefore, it may 
      play an important role as a predictive model of NSTE-ACS patients in clinical 
      practice.
FAU - Tasolar, Hakan
AU  - Tasolar H
AD  - Department of Cardiology, Adiyaman University, Training and Research Hospital, 
      Adiyaman-Turkey. hakantasolar@gmail.com.
FAU - Cetin, Mustafa
AU  - Cetin M
AD  - Department of Cardiology, Adiyaman University, Training and Research Hospital, 
      Adiyaman-Turkey.
FAU - Balli, Mehmet
AU  - Balli M
AD  - Department of Cardiology, Adiyaman University, Training and Research Hospital, 
      Adiyaman-Turkey.
FAU - Bayramoglu, Adil
AU  - Bayramoglu A
AD  - Department of Cardiology, Ordu University, Training and Research Hospital, 
      Ordu-Turkey.
FAU - Otlu, Yilmaz Omur
AU  - Otlu YO
AD  - Department of Cardiology, Kars State Hospital, Kars-Turkey.
FAU - Turkmen, Serdar
AU  - Turkmen S
AD  - Department of Cardiology, Adiyaman University, Training and Research Hospital, 
      Adiyaman-Turkey.
FAU - Akturk, Erdal
AU  - Akturk E
AD  - Department of Cardiology, Adiyaman University, Training and Research Hospital, 
      Adiyaman-Turkey.
LA  - eng
PT  - Journal Article
DEP - 20160323
PL  - Turkey
TA  - Anatol J Cardiol
JT  - Anatolian journal of cardiology
JID - 101652981
SB  - IM
MH  - Acute Coronary Syndrome/classification/*diagnosis
MH  - Aged
MH  - Coronary Artery Disease/classification/*diagnosis
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Severity of Illness Index
PMC - PMC5324933
COIS- Conflict of interest: None declared.
EDAT- 2016/03/31 06:00
MHDA- 2018/10/20 06:00
PMCR- 2016/10/01
CRDT- 2016/03/31 06:00
PHST- 2016/03/31 06:00 [pubmed]
PHST- 2018/10/20 06:00 [medline]
PHST- 2016/03/31 06:00 [entrez]
PHST- 2016/10/01 00:00 [pmc-release]
AID - AJC-16-742 [pii]
AID - 10.14744/AnatolJCardiol.2015.6593 [doi]
PST - ppublish
SO  - Anatol J Cardiol. 2016 Oct;16(10):742-748. doi: 
      10.14744/AnatolJCardiol.2015.6593. Epub 2016 Mar 23.