PMID- 27025662
OWN - NLM
STAT- MEDLINE
DCOM- 20171003
LR  - 20171116
IS  - 2239-253X (Electronic)
IS  - 0003-469X (Linking)
VI  - 87
DP  - 2016
TI  - Minimal effective dose of povidone-iodine in abdominal surgery Our clinical 
      experience.
PG  - 45-8
LID - S0003469X16024623 [pii]
AB  - The aim of this study is to evaluate the thyroid function tests in order to 
      examine whether 10 % of Povidone-Iodine(PI), the medication we applied in 1/5 
      ratio diluted with 0.9 %NaCl, joins the systemic circulation during clean 
      contaminated, contaminated and dirty operations for solid organ hydatid cysts in 
      abdominal area to avoid abscess formation and spreading. 7 men and 6 women were 
      included to the present study, prospectively. The mean age was 33.69(+/- 13.49). 
      TSH, free T3 (fT3) and free T4 (fT4) hormone levels were measured before the 
      operation and at the third day of postoperative period. Amount of used 
      povidone-iodine for patients was recorded. As a result of statistical analysis 
      applied, the preoperative and post operative values were not significantly 
      different regarding with the measured hormone levels (preTSH vs postTSH: p= 
      0.984; prefT3 vs postfT3: p= 0.101; prefT4 vs postfT4: p=0.146). Thus, it has 
      been shown that the dose we used is effective, and it does not enters at all or 
      at quite low levels into the systemic circulation. Patients whom this application 
      performed, abscess and intestinal adhesions have not been observed in our 
      clinical experience. We recommend the use of suggested doses of Povidone-Iodine 
      in the presence of intraabdominal perforation and abscess or in cases such as 
      carrying a risk of cyst spreading to intraabdominal area in hydatid cysts. KEY 
      WORDS: Povidone-iodine, Surgical adhesions, Surgical wound infections, Thyroid 
      function tests.
FAU - Gozeneli, Orhan
AU  - Gozeneli O
FAU - Yucel, Yusuf
AU  - Yucel Y
FAU - Akal, Ali
AU  - Akal A
FAU - Terzi, Alpaslan
AU  - Terzi A
FAU - Ozgonul, Abdullah
AU  - Ozgonul A
FAU - Tatli, Faik
AU  - Tatli F
FAU - Ciftci, Resit
AU  - Ciftci R
FAU - Gumer, Mehmet
AU  - Gumer M
FAU - Uzunkoy, Ali
AU  - Uzunkoy A
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Ann Ital Chir
JT  - Annali italiani di chirurgia
JID - 0372343
RN  - 0 (Anti-Infective Agents, Local)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 85H0HZU99M (Povidone-Iodine)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Abdomen
MH  - Abscess/prevention & control
MH  - Adolescent
MH  - Adult
MH  - Anti-Infective Agents, Local/*administration & dosage/adverse 
      effects/pharmacokinetics
MH  - Dose-Response Relationship, Drug
MH  - Echinococcosis/*surgery
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/prevention & control
MH  - Postoperative Period
MH  - Povidone-Iodine/*administration & dosage/adverse effects/pharmacokinetics
MH  - Prospective Studies
MH  - Skin Absorption
MH  - Surgical Wound Infection/*prevention & control
MH  - Thyroid Gland/*drug effects
MH  - Thyroxine/blood
MH  - Tissue Adhesions/chemically induced/prevention & control
MH  - Triiodothyronine/blood
MH  - Young Adult
EDAT- 2016/03/31 06:00
MHDA- 2017/10/04 06:00
CRDT- 2016/03/31 06:00
PHST- 2016/03/31 06:00 [entrez]
PHST- 2016/03/31 06:00 [pubmed]
PHST- 2017/10/04 06:00 [medline]
AID - S0003469X16024623 [pii]
PST - ppublish
SO  - Ann Ital Chir. 2016;87:45-8.