PMID- 27026173
OWN - NLM
STAT- MEDLINE
DCOM- 20170223
LR  - 20201216
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 80
IP  - 5
DP  - 2016 Apr 25
TI  - Exhaled Acetone Concentration Is Related to Hemodynamic Severity in Patients With 
      Non-Ischemic Chronic Heart Failure.
PG  - 1178-86
LID - 10.1253/circj.CJ-16-0011 [doi]
AB  - BACKGROUND: We hypothesized that exhaled acetone concentration (EAC), reflecting 
      altered blood ketone body metabolism and increased acetone exhaust because of 
      pulmonary congestion in heart failure (HF), would correlate with hemodynamic 
      parameters in patients with non-ischemic chronic HF. METHODS AND RESULTS: We 
      prospectively enrolled 102 non-ischemic HF patients with New York Heart 
      Association (NYHA) class I-III. Exhaled breath was collected after an overnight 
      fast. Echocardiography and cardiac catheterization were performed in all 
      patients. We also enrolled 17 control patients without HF. EAC in the HF patients 
      was significantly higher than that in the control patients (median EAC; 0.53 vs. 
      0.38 ppm, P=0.012). EAC positively correlated with blood total ketone bodies 
      (r=0.454, P<0.001), NYHA class (r=0.489, P<0.001), and plasma B-type natriuretic 
      peptide (r=0.316, P=0.001). Right heart catheterization revealed that EAC 
      significantly correlated with pulmonary capillary wedge pressure (PCWP, r=0.377, 
      P<0.001). Receiver-operating characteristic analysis revealed that EAC >1.05 ppm 
      was associated with PCWP >/=18 mmHg (area under the curve [AUC] 0.726, sensitivity 
      50%, specificity 89%). EAC was shown to be a comparable diagnostic biomarker for 
      HF to BNP (AUC 0.760, sensitivity 80%, specificity 70%). CONCLUSIONS: EAC may be 
      a novel noninvasive biomarker that correlates hemodynamic severity in 
      non-ischemic chronic HF. (Circ J 2016; 80: 1178-1186).
FAU - Yokokawa, Tetsuro
AU  - Yokokawa T
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center.
FAU - Sugano, Yasuo
AU  - Sugano Y
FAU - Shimouchi, Akito
AU  - Shimouchi A
FAU - Shibata, Atsushi
AU  - Shibata A
FAU - Jinno, Naoya
AU  - Jinno N
FAU - Nagai, Toshiyuki
AU  - Nagai T
FAU - Kanzaki, Hideaki
AU  - Kanzaki H
FAU - Aiba, Takeshi
AU  - Aiba T
FAU - Kusano, Kengo
AU  - Kusano K
FAU - Shirai, Mikiyasu
AU  - Shirai M
FAU - Takeishi, Yasuchika
AU  - Takeishi Y
FAU - Yasuda, Satoshi
AU  - Yasuda S
FAU - Ogawa, Hisao
AU  - Ogawa H
FAU - Anzai, Toshihisa
AU  - Anzai T
LA  - eng
PT  - Journal Article
DEP - 20160329
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (Biomarkers)
RN  - 1364PS73AF (Acetone)
SB  - IM
MH  - Acetone/*analysis
MH  - Biomarkers
MH  - Breath Tests/methods
MH  - Case-Control Studies
MH  - Chronic Disease
MH  - Exhalation
MH  - Heart Failure/*diagnosis
MH  - Hemodynamics/*physiology
MH  - Humans
MH  - Prospective Studies
MH  - Severity of Illness Index
EDAT- 2016/03/31 06:00
MHDA- 2017/02/24 06:00
CRDT- 2016/03/31 06:00
PHST- 2016/03/31 06:00 [entrez]
PHST- 2016/03/31 06:00 [pubmed]
PHST- 2017/02/24 06:00 [medline]
AID - 10.1253/circj.CJ-16-0011 [doi]
PST - ppublish
SO  - Circ J. 2016 Apr 25;80(5):1178-86. doi: 10.1253/circj.CJ-16-0011. Epub 2016 Mar 
      29.